1,24-dihydroxyvitamin d2 profile

1,24-dihydroxyvitamin D2 (also known as calcifediol) is a **metabolite of vitamin D2**, which is a form of vitamin D produced by the body upon exposure to ultraviolet (UV) light.

**Here's why it's important for research:**

* **Regulation of calcium and phosphorus:** Like other vitamin D metabolites, calcifediol plays a vital role in regulating calcium and phosphorus levels in the blood. It does this by increasing intestinal absorption of calcium and promoting calcium reabsorption in the kidneys. This is crucial for bone health, muscle function, and various other physiological processes.

* **Immune modulation:** Studies have shown that calcifediol can modulate the immune system, potentially influencing the development and progression of certain diseases. It has been linked to:
* **Reduced risk of autoimmune diseases:** Some research suggests that calcifediol may have a protective effect against autoimmune diseases such as multiple sclerosis and type 1 diabetes.
* **Anti-inflammatory properties:** Calcifediol has been shown to have anti-inflammatory effects, which could be beneficial for conditions like inflammatory bowel disease and rheumatoid arthritis.

* **Potential for treating other diseases:** Research is ongoing to investigate the potential of calcifediol in treating other conditions, such as:
* **Cancer:** There is evidence that calcifediol may have anti-cancer properties, particularly for certain types of cancer.
* **Cardiovascular disease:** Some studies suggest that calcifediol could play a role in preventing and managing cardiovascular disease.

* **Metabolic health:** Calcifediol might also have a role in regulating metabolism, potentially impacting conditions like obesity and diabetes.

**Important considerations:**

* **Different from Vitamin D3:** While calcifediol is a metabolite of vitamin D2, it is not the same as the more familiar vitamin D3 (cholecalciferol). While both have similar roles in the body, they differ in their chemical structure and biological activity.
* **Research is ongoing:** While promising, research on calcifediol is still ongoing and much is yet to be learned about its precise mechanisms of action and long-term effects.

In summary, 1,24-dihydroxyvitamin D2 is a crucial metabolite of vitamin D with important roles in calcium regulation, immune function, and potential for treating various diseases. Research continues to explore its potential benefits and broaden our understanding of this vital molecule.

1,24-dihydroxyvitamin D2: LR-103 has antineoplastic activity; RN & structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	156963179
MeSH ID	M0174305

Synonym
1,24-dihydroxyvitamin d2

Excerpt	Relevance	Reference
" Dose-response curves generated after oral and subcutaneous administration of 1 alpha,24(OH)2D2, calcitriol, and calcipotriol to normal rats indicated that 1 alpha,24(OH)2D2 increases serum and urine calcium to a much lesser extent than calcitriol, and to a slightly greater extent than calcipotriol."	( Pharmacokinetics and systemic effect on calcium homeostasis of 1 alpha,24-dihydroxyvitamin D2 in rats. Comparison with 1 alpha,25-dihydroxyvitamin D2, calcitriol, and calcipotriol. Bishop, CW; Knutson, JC; LeVan, LW; Valliere, CR, 1997)	0.3
" The rats were dosed orally with each sterol for 7 days at a rate of 1 ng/g body weight/day."	( Comparison of the relative effects of 1,24-dihydroxyvitamin D(2) [1, 24-(OH)(2)D(2)], 1,24-dihydroxyvitamin D(3) [1,24-(OH)(2)D(3)], and 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] on selected vitamin D-regulated events in the rat. Bishop, C; Horst, R; Knutson, J; Koszewski, N; Prapong, S; Reinhardt, T, 2000)	0.31
"Combined dosing of pamidronate and 1,24(OH)2D2 may have therapeutic value for the treatment of multiple myeloma, prostate and breast cancers."	( Pamidronate and 1,24(S)-dihydroxyvitamin D2 synergistically inhibit the growth of myeloma, breast and prostate cancer cells. Knutson, JC; Strugnell, SA; Wigington, DP, )	0.13

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	6 (50.00)	18.2507
2000's	5 (41.67)	29.6817
2010's	1 (8.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (5.88%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (94.12%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
metribolone Metribolone: A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.. 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one : A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.	2.01	1	0	17beta-hydroxy steroid; 3-oxo steroid; anabolic androgenic steroid	androgen
calcitriol dihydroxy-vitamin D3: as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes	3.25	6	0	D3 vitamins; hydroxycalciol; triol	antineoplastic agent; antipsoriatic; bone density conservation agent; calcium channel agonist; calcium channel modulator; hormone; human metabolite; immunomodulator; metabolite; mouse metabolite; nutraceutical
vitamin d 2 Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.. vitamin D2 : A vitamin D supplement and has been isolated from alfalfa.	5.26	12	1	hydroxy seco-steroid; seco-ergostane; vitamin D	bone density conservation agent; nutraceutical; plant metabolite; rodenticide
cholecalciferol Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	1.97	1	0	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite
24-hydroxyvitamin d2 24-hydroxyvitamin D2: metabolite of vitamin D2; RN given refers to (3beta,5Z,7E,22E,24xi)-isomer	7.39	2	0	vitamin D
1,25-dihydroxyergocalciferol 1,25-dihydroxyergocalciferol: RN given refers to (3beta,5Z,7E,22E)-isomer. 1alpha,25-dihydroxyvitamin D2 : A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25.	2.38	2	0	hydroxycalciol; seco-ergostane; vitamin D	bone density conservation agent; human xenobiotic metabolite; nutraceutical
1 alpha,24-dihydroxyvitamin d3 1 alpha,24-dihydroxyvitamin D3: RN refers to (1alpha,3beta,5Z,7E)-isomer; formulated in ointment at a concentration of 4 microg/g, for treatment of mild psoriasis	2	1	0

Condition	Relationship Strength	Studies	Trials
Hypercalciuria Excretion of abnormally high level of CALCIUM in the URINE, greater than 4 mg/kg/day.	3.5	1	1
Milk-Alkali Syndrome [description not available]	4.12	3	1
Benign Neoplasms [description not available]	3.5	1	1
Hypercalcemia Abnormally high level of calcium in the blood.	4.12	3	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.5	1	1
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	3.5	1	1
Calcification, Pathologic [description not available]	2.04	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.04	1	0
Secondary Hyperparathyroidism [description not available]	2.04	1	0
Deficiency, Vitamin D [description not available]	2.7	3	0
Calcinosis Pathologic deposition of calcium salts in tissues.	2.04	1	0
Hyperparathyroidism, Secondary Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.	2.04	1	0
Vitamin D Deficiency A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)	2.7	3	0
Carcinoma, Anaplastic [description not available]	2.01	1	0
Cancer of Prostate [description not available]	2.01	1	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.01	1	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.01	1	0
Osteogenic Sarcoma [description not available]	1.98	1	0
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	1.98	1	0
Hepatocellular Carcinoma [description not available]	1.98	1	0
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	1.98	1	0

1,24-dihydroxyvitamin d2

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Research

Studies (12)

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