ketoconazole has been researched along with Hypercalciuria in 3 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Hypercalciuria: Excretion of abnormally high level of CALCIUM in the URINE, greater than 4 mg/kg/day.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a syndrome characterized by intermittent hypercalcemia, hypercalciuria, elevated 1,25-dihydroxyvitamin D, undetectable 24,25-dihydroxyvitamin D concentrations, splice junction mutations of the CYP24A1 gene, and autosomal dominant transmission of the trait, treatment with ketoconazole is useful in reducing urinary calcium." | 7.78 | Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy. ( Chelminski, PR; Foreman, JW; Harris, PC; Horst, RL; Kumar, R; Milliner, DS; Singh, RJ; Tebben, PJ; Wu, Y, 2012) |
| "To analyze vitamin D metabolism and response to ketoconazole, an imidazole derivative that inhibits the vitamin D-1-hydroxylase, in infants with idiopathic hypercalcemia, and hypercalciuria." | 7.76 | Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment. ( Boutignon, H; Garabedian, M; Guillozo, H; Jehan, F; Linglart, A; Mallet, E; Nguyen, M, 2010) |
| "In a syndrome characterized by intermittent hypercalcemia, hypercalciuria, elevated 1,25-dihydroxyvitamin D, undetectable 24,25-dihydroxyvitamin D concentrations, splice junction mutations of the CYP24A1 gene, and autosomal dominant transmission of the trait, treatment with ketoconazole is useful in reducing urinary calcium." | 3.78 | Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy. ( Chelminski, PR; Foreman, JW; Harris, PC; Horst, RL; Kumar, R; Milliner, DS; Singh, RJ; Tebben, PJ; Wu, Y, 2012) |
| "To analyze vitamin D metabolism and response to ketoconazole, an imidazole derivative that inhibits the vitamin D-1-hydroxylase, in infants with idiopathic hypercalcemia, and hypercalciuria." | 3.76 | Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment. ( Boutignon, H; Garabedian, M; Guillozo, H; Jehan, F; Linglart, A; Mallet, E; Nguyen, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, M | 1 |
| Boutignon, H | 1 |
| Mallet, E | 1 |
| Linglart, A | 1 |
| Guillozo, H | 1 |
| Jehan, F | 1 |
| Garabedian, M | 1 |
| Tebben, PJ | 1 |
| Milliner, DS | 1 |
| Horst, RL | 1 |
| Harris, PC | 1 |
| Singh, RJ | 1 |
| Wu, Y | 1 |
| Foreman, JW | 1 |
| Chelminski, PR | 1 |
| Kumar, R | 1 |
| Carpenter, TO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Idiopathic Infantile Hypercalcemia[NCT03384121] | Phase 1 | 5 participants (Anticipated) | Interventional | 2018-02-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for ketoconazole and Hypercalciuria
| Article | Year |
|---|---|
Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment.
Topics: Calcium; Female; Fibroblast Growth Factor-23; Haplotypes; Humans; Hypercalcemia; Hypercalciuria; Inf | 2010 |
Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy.
Topics: 14-alpha Demethylase Inhibitors; Adult; Calcitriol; Genotype; Humans; Hypercalcemia; Hypercalciuria; | 2012 |
Take another CYP: confirming a novel mechanism for "idiopathic" hypercalcemia.
Topics: 14-alpha Demethylase Inhibitors; Calcitriol; Humans; Hypercalcemia; Hypercalciuria; Ketoconazole; Ma | 2012 |