interleukin-8 and Snoring

To analyze the method and the effect of airway intervention before tracheal extubation in post-anesthesia cure unit (PACU) after anesthesia when removing the tonsil under general anesthesia and adenoidectomy under nasal endoscope on children with snoring.. 46 cases diagnosed as snoring were executively selected in this study. The cases were randomly divided into the control group (n = 22) and the observation group (n = 24). For airway intervention after general anesthesia during the recovery period, the control group was treated with intravenous injection of 0.5 μg/kg remifentanil, whereas the observation group was treated with atomization inhalation of 15 mg ambroxol hydrochloride and 0.5 mg budesonide suspension.. The clinical effects of both methods were compared and analyzed for statistical analysis. The blood pressure, heart rate and blood oxygen saturation at 30 min and 10 min after extubation in the control group was significantly more stable than those in the observation group (p < 0.05). The alertness/sedation (OAA/S) score in the observation group was significantly higher than that in the control group (p < 0.05). The prevalence rate of complications after extubation in the two groups was not statistically significant (p > 0.05). The levels of serum cortisol (Cor) and IL-8 in the control group were significantly lower than those in the observation group (p < 0.05).. Both methods are effective for treatment of airway intervention concerned with snoring children after general anesthesia during the recovery period. The effect of remifentanil on hemodynamics is relatively huge compared with that of atomization inhalation.

Topics: Adenoidectomy; Adolescent; Airway Extubation; Ambroxol; Anesthesia Recovery Period; Anesthesia, General; Blood Pressure; Budesonide; Case-Control Studies; Child; Female; Heart Rate; Humans; Hydrocortisone; Interleukin-8; Male; Oximetry; Piperidines; Remifentanil; Snoring

Obstructive sleep apnoea (OSA) is associated with pharyngeal inflammation, but the coexistence of systemic inflammation is controversial. This study investigated whether local and systemic inflammatory biomarkers are related in patients with OSA. An uncontrolled extension to the study assessed the response to effective treatment.We recruited 89 patients with OSA (apnoea/hypopnoea index (AHI) ≥5 events·h

Topics: Adolescent; Adult; Anthropometry; Biomarkers; Case-Control Studies; CD4-Positive T-Lymphocytes; Continuous Positive Airway Pressure; Female; Flow Cytometry; Humans; Immunoassay; Inflammation; Interleukin-6; Interleukin-8; Male; Middle Aged; Prospective Studies; Sleep Apnea, Obstructive; Snoring; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult

To test a cell model of snoring-induced airway inflammation and to assess whether a vibration stimulus simulating the one experienced by airway tissues in snoring patients induces inflammation in airway epithelial cells.. Prospective controlled study in cell culture.. University laboratory.. Human bronchial epithelial cells (BEAS-2B cell line).. Cell cultures were subjected to vibration (60 Hz, +/- 0.3 mm) for time periods of 6 hours, 12 hours, and 24 hours. The vibratory stimulus was applied with and without treatment with inhibitors of the 3 main pathways of mitogen-activated protein kinases (MAPK): p38, MEK1/2, and JNK.. The effect of vibration was assessed by comparing cell proliferation and release of interleukin-8 (IL-8; measured by enzyme-linked immunosorbent assay) in cells subjected to the vibratory stimulus (both when treated and untreated with MAPK inhibitors) and in controls. Application of vibration up to 24 hours did not significantly modify cell proliferation. By contrast, the concentration of IL-8 in the supernatant was significantly increased after 12 hours and 24 hours of vibration. The inhibition of the p38, MEK1/2, and JNK MAPK pathways significantly reduced the overexpression of IL-8 resulting from the vibration stimulus.. A mechanical vibration simulating snoring triggered an inflammatory cascade, as reflected by the increase in IL-8 release mediated by MAPK pathways. The novel model developed is potentially applicable to studying the effects of the vibration due to snoring in the different cell types (epithelial, endothelial, muscular, neuronal) involved in airway pathophysiology during respiratory sleep disturbances.

Topics: Biomarkers; Bronchi; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Interleukin-8; Prospective Studies; Respiratory Mucosa; Signal Transduction; Snoring; Time Factors; Vibration