suramin has been researched along with Onchocerciasis in 80 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Onchocerciasis: Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ten male patients with onchocerciasis received six weekly infusions of suramin according to the WHO-recommended regimen." | 9.08 | Clinical pharmacokinetics of suramin in patients with onchocerciasis. ( Chijioke, CP; Fleckenstein, LL; Mbah, AU; Nwonu, P; Okonkwo, PO; Umeh, RE, 1998) |
| "39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years." | 9.04 | Effects of suramin on ocular onchocerciasis. ( Anderson, J; de C Marshall, TF; Fuglsang, H, 1976) |
| "In a village hyperendemic for onchocerciasis in Burkina Faso, where the vector had been controlled by the Onchocerciasis Control Programme since 1976, 65 patients were treated with doses of 37 to 71 mg/kg suramin in 1979." | 7.67 | Suramin in the treatment of onchocerciasis: the efficacy of low doses on the parasite in an area with vector control. ( Karam, M; Prost, A; Schulz-Key, H, 1985) |
| "Treatment of onchocerciasis with suramin in an area of vector control led to an increased incidence of optic atrophy in treated patients compared to an untreated group." | 7.66 | The risk of optic atrophy following suramin treatment of ocular onchocerciasis. ( Rolland, A; Thylefors, B, 1979) |
| "In 1959 a population of 638 persons over the age of seven years, suffering from heavy endemic onchocerciasis in the Sudan-Savannah of West Africa was examined, and approximately half were allotted to a group for treatment with suramin (up to a total of 4-2 g for healthy adults)." | 7.65 | The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy. ( Budden, FH, 1976) |
| "Ten male patients with onchocerciasis received six weekly infusions of suramin according to the WHO-recommended regimen." | 5.08 | Clinical pharmacokinetics of suramin in patients with onchocerciasis. ( Chijioke, CP; Fleckenstein, LL; Mbah, AU; Nwonu, P; Okonkwo, PO; Umeh, RE, 1998) |
| "39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years." | 5.04 | Effects of suramin on ocular onchocerciasis. ( Anderson, J; de C Marshall, TF; Fuglsang, H, 1976) |
| "Suramin and Mel W are the only two drugs at present known to be effective against the adult worms of Onchocerca volvulus, but in view of the unpredictable occurrence of fatal arsenical encephalopathy in a small proportion of patients receiving Mel W, suramin remains the preferred macrofilaricide in the treatment of onchocerciasis." | 5.03 | The effects of drugs on Onchocerca volvulus. 3. Trials of suramin at different dosages and a comparison of the brands Antrypol, Moranyl and Naganol. ( Duke, BO, 1968) |
| "1 G suramin course for cutaneous onchocerciasis." | 3.68 | Suramin and the time it takes to kill Onchocerca volvulus. ( Duke, BO, 1991) |
| "The treatment of onchocerciasis using diethylcarbamazine and suramin sodium, which can kill different stages of the parasite, Onchocerca volvulus, remains unsatisfactory." | 3.67 | Recent developments in the treatment of onchocerciasis. ( Taylor, HR, 1984) |
| "Treatment of onchocerciasis with suramin in an area of vector control led to an increased incidence of optic atrophy in treated patients compared to an untreated group." | 3.66 | The risk of optic atrophy following suramin treatment of ocular onchocerciasis. ( Rolland, A; Thylefors, B, 1979) |
| "In 1959 a population of 638 persons over the age of seven years, suffering from heavy endemic onchocerciasis in the Sudan-Savannah of West Africa was examined, and approximately half were allotted to a group for treatment with suramin (up to a total of 4-2 g for healthy adults)." | 3.65 | The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy. ( Budden, FH, 1976) |
| "Previous work on monkeys and on human volunteers led to the development of a schedule of diethylcarbamazine dosage suitable for the chemoprophylaxis of loiasis." | 2.63 | Experiments on the chemoprophylaxis of Onchocerca volvulus infection. ( Duke, BO, 1968) |
| "Suramin is a polysulfonated polyaromatic symmetrical urea." | 2.44 | Suramin: clinical uses and structure-activity relationships. ( Bennett, AJ; Cosgrove, KL; McGeary, RP; Ross, BP; Tran, QB, 2008) |
| "In our population filariasis is mainly imported from central and western Africa, especially Cameroon." | 1.26 | [Filariasis in patients returned from the tropics. Studies on 64 cases]. ( Degrémont, A; Stürchler, D, 1976) |
| "When diethylcarbamazine (DEC) was given after suramin, increased numbers of microfilariae appeared in the blood, urine, cerebrospinal fluid (CSF) and sputum, but the increase in the blood was less marked, and of shorter duration, than in similar patients receiving DEC without previous suramin." | 1.26 | The populatin dynamics of Onchocerca volvulus microfilariae during treatment with suramin and diethylcarbamazine. ( Duke, BO; Moore, PJ; Vincelette, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (85.00) | 18.7374 |
| 1990's | 11 (13.75) | 18.2507 |
| 2000's | 1 (1.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McGeary, RP | 1 |
| Bennett, AJ | 1 |
| Tran, QB | 1 |
| Cosgrove, KL | 1 |
| Ross, BP | 1 |
| RUIZ REYES, F | 1 |
| COLBOURNE, MJ | 1 |
| HUTTON, PW | 1 |
| IKEJIANI, O | 1 |
| CHARTERS, JC | 1 |
| NELSON, GS | 2 |
| CONRAN, OF | 1 |
| WADDY, BB | 1 |
| HAWKING, F | 2 |
| CHERRY, JK | 1 |
| NNOCHIRI, E | 1 |
| GONZALEZGUERRA, L | 1 |
| RASI, E | 1 |
| RIVAS, A | 1 |
| BURCH, TA | 4 |
| AGUILAR, GG | 1 |
| BARRERA, M | 1 |
| DALMAT, HT | 1 |
| ASHBURN, LL | 1 |
| SARKIES, JW | 1 |
| Taylor, HR | 1 |
| Büttner, DW | 4 |
| Goodwin, LG | 1 |
| Rougemont, A | 2 |
| Hien, M | 1 |
| Thylefors, B | 7 |
| Prost, A | 4 |
| Rolland, A | 5 |
| Duke, BO | 12 |
| Somorin, AO | 1 |
| Ducam, M | 1 |
| Ranque, P | 1 |
| Delmont, J | 1 |
| Mahoney, JL | 1 |
| Scharlau, G | 1 |
| Wolf, H | 1 |
| Schulz-Key, H | 2 |
| Albiez, EJ | 2 |
| Geister, R | 1 |
| Awadzi, K | 5 |
| Hero, M | 1 |
| Opoku, NO | 1 |
| Addy, ET | 1 |
| Ginger, CD | 1 |
| Renz, A | 3 |
| Trees, AJ | 3 |
| Achu-Kwi, D | 2 |
| Edwards, G | 4 |
| Wahl, G | 2 |
| Darge, K | 1 |
| Troeger, J | 1 |
| Engelke, C | 1 |
| Leichsenring, M | 1 |
| Nelle, M | 1 |
| Buettner, DW | 1 |
| Voogd, TE | 1 |
| Vansterkenburg, EL | 1 |
| Wilting, J | 1 |
| Janssen, LH | 1 |
| Cross, HF | 1 |
| Bronsvoort, BM | 1 |
| Chijioke, CP | 1 |
| Umeh, RE | 1 |
| Mbah, AU | 1 |
| Nwonu, P | 1 |
| Fleckenstein, LL | 1 |
| Okonkwo, PO | 1 |
| Wood, VL | 1 |
| Bronsvoort, M | 1 |
| Tanya, VN | 1 |
| Harley, RD | 1 |
| Stürchler, D | 1 |
| Degrémont, A | 1 |
| Anderson, J | 5 |
| Fuglsang, H | 5 |
| Coperman, DB | 1 |
| Vingtain, P | 1 |
| Lucot, J | 1 |
| Chovet, M | 1 |
| Porto, MA | 1 |
| Budden, FH | 1 |
| Gibson, DW | 1 |
| Connor, DH | 1 |
| Vincelette, J | 2 |
| Moore, PJ | 2 |
| de C Marshall, TF | 1 |
| Coyne, PE | 1 |
| Maxwell, C | 1 |
| Orme, M | 2 |
| Breckenridge, A | 1 |
| von Essen, J | 1 |
| Erichsen, J | 1 |
| Newsome, F | 1 |
| Breckenridge, AM | 2 |
| Abdel Fattah, A | 1 |
| Youssif, NM | 1 |
| Shenouda, OA | 1 |
| Morsy, TA | 1 |
| Rodick, CL | 1 |
| Ward, SA | 1 |
| Orme, ML | 1 |
| Karam, M | 1 |
| Grüntzig, J | 1 |
| Toufic, N | 1 |
| Smit, AM | 1 |
| Zuidema, PJ | 1 |
| Lämmler, G | 1 |
| Herzog, H | 1 |
| Kennedy, P | 1 |
| Terry, S | 1 |
| Scheie, HG | 1 |
| Shannon, RE | 1 |
| Yanoff, M | 1 |
| Janssens, PG | 1 |
| Gornig, H | 1 |
| Prix, R | 1 |
| Jindrák, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis[NCT03517462] | 231 participants (Actual) | Interventional | 2018-08-06 | Completed | |||
| Safety and Efficacy of Combination Therapy With Ivermectin, Diethylcarbamazine, and Albendazole (IDA) for Individuals With Onchocerciasis[NCT04188301] | Phase 2 | 154 participants (Actual) | Interventional | 2019-12-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The effectiveness of three treatment regimens for killing adult female O. volvulus worms based on the percentage of all adult female worms in nodules that are alive 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment
| Intervention | Female worms in nodule (Count of Units) |
|---|---|
| IVM + ALB | 127 |
| IDA x 1 Dose | 142 |
| IDA x 3 Doses | 159 |
The effect of three treatment regimens for killing adult female O. volvulus worms will be compared based on the percentage of all adult female worms in nodules that are alive with embryos in the uterus 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment.
| Intervention | Female worms in nodules (Count of Units) |
|---|---|
| IVM + ALB | 127 |
| IDA x 1 Dose | 142 |
| IDA x 3 Doses | 159 |
The effect of three treatment regimens for sterilizing adult female O. volvulus worms will be compared based on the percentage of all adult female worms that are fertile in the nodules 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment.
| Intervention | Female worms with intact uterus (Count of Units) |
|---|---|
| IVM + ALB | 41 |
| IDA x 1 Dose | 40 |
| IDA x 3 Doses | 34 |
Rates of ocular adverse events of any grade within 3 months will be compared by treatment group. (NCT04188301)
Timeframe: within 3 months of treatment with IDA
| Intervention | Participants (Count of Participants) |
|---|---|
| IVM + ALB | 4 |
| IDA x 1 Dose | 4 |
| IDA x 3 Doses | 3 |
Rates of adverse events grade 3 or higher that occur within 7 days of treatment in the subset of participants who have intraocular microfilariae just prior to treatment with IDA will be compared by treatment group. (NCT04188301)
Timeframe: within 7 days following end of treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| IVM + ALB | 0 |
| IDA x 1 Dose | 0 |
| IDA x 3 Doses | 0 |
Rates of severe adverse events (grade 3 or higher) following 1-day or 3-day triple drug treatment will be compared against those of the comparator regimen of 1 day of IVM/ALB. (NCT04188301)
Timeframe: Within 7 days following end of treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| IVM + ALB | 0 |
| IDA x 1 Dose | 0 |
| IDA x 3 Doses | 0 |
The effectiveness of three treatment regimens for preventing reappearance of microfilariae in the skin as determined by skin snips at 12 and 18 months after treatment will be compared by treatment arm. Measured by the presence of microfilariae in skin snips. (NCT04188301)
Timeframe: Baseline, 12 months, and 18 months following treatment
| Intervention | Count of microfilarae+ participants (Number) | ||
|---|---|---|---|
| Baseline | Month 12 | Month 18 | |
| IDA x 1 Dose | 6 | 21 | 15 |
| IDA x 3 Doses | 0 | 21 | 17 |
| IVM + ALB | 7 | 23 | 20 |
The effectiveness of three treatment regimens for complete clearance of microfilariae from the skin as determined by skin snips at 3, 12, and 18 months after treatment with IDA will be compared by treatment arm. (NCT04188301)
Timeframe: Baseline, 3 months, 12 months, & 18 months following treatment.
| Intervention | Count of Skin Microfilaria (Geometric Mean) | |||
|---|---|---|---|---|
| Baseline | Month 3 | Month 12 | Month 18 | |
| IDA x 1 Dose | 1.7 | 3 | 2.5 | 9.0 |
| IDA x 3 Doses | NA | 2.1 | 4.7 | 8.6 |
| IVM + ALB | 3.1 | 1.9 | 4.9 | 7.0 |
9 reviews available for suramin and Onchocerciasis
| Article | Year |
|---|---|
Suramin: clinical uses and structure-activity relationships.
Topics: Animals; Antineoplastic Agents; Humans; Neoplasms; Onchocerciasis; Structure-Activity Relationship; | 2008 |
Recent advances in research on filariasis. Chemotherapy.
Topics: Animals; Anti-Inflammatory Agents; Arsenicals; Benzimidazoles; Diethylcarbamazine; Drug Evaluation, | 1984 |
Recent research on the biological activity of suramin.
Topics: Acquired Immunodeficiency Syndrome; Animals; Filarioidea; Humans; Neoplasms; Onchocerciasis; Recepto | 1993 |
Ocular onchocerciasis.
Topics: Diethylcarbamazine; Eye; Eye Diseases; Female; Glaucoma; Humans; Iritis; Keratitis; Male; Onchocerci | 1977 |
Suramin: with special reference to onchocerciasis.
Topics: Animals; Blood Coagulation; Chemical Phenomena; Chemistry; Filaricides; Humans; Lysosomes; Onchocerc | 1978 |
Clinical pharmacokinetics of drugs against onchocerciasis.
Topics: Anthelmintics; Benzimidazoles; Diethylcarbamazine; Filaricides; Humans; Ivermectin; Onchocerciasis; | 1990 |
Drug treatment of onchocerciasis.
Topics: Diethylcarbamazine; Humans; Ivermectin; Levamisole; Onchocerciasis; Suramin | 1988 |
Onchocerciasis.
Topics: Africa; Animals; Blindness; DDT; Eye; Female; Filarioidea; Humans; Insect Vectors; Insecticides; Lar | 1972 |
Onchocerciasis.
Topics: Africa; Animals; Anthelmintics; Artiodactyla; Blindness; Cattle; Circadian Rhythm; DDT; Diethylcarba | 1970 |
8 trials available for suramin and Onchocerciasis
| Article | Year |
|---|---|
The chemotherapy of onchocerciasis XVIII. Aspects of treatment with suramin.
Topics: Adult; Animals; Female; Follow-Up Studies; Humans; Male; Mitosis; Onchocerca volvulus; Onchocerciasi | 1995 |
Evaluation of suramin, ivermectin and CGP 20376 in a new macrofilaricidal drug screen, Onchocerca ochengi in African cattle.
Topics: Africa; Animals; Cattle; Cattle Diseases; Drug Evaluation, Preclinical; Female; Filaricides; Follow- | 1995 |
Evaluation of ultrasonography for the detection of drug-induced changes in onchocercal nodules.
Topics: Adult; Animals; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Male; Middle Aged; O | 1994 |
Clinical pharmacokinetics of suramin in patients with onchocerciasis.
Topics: Adult; Animals; Antinematodal Agents; Exanthema; Foot; Humans; Hypopigmentation; Male; Metabolic Cle | 1998 |
Effects of suramin on ocular onchocerciasis.
Topics: Adolescent; Adult; Anterior Chamber; Cornea; Eye Diseases; Female; Fundus Oculi; Glaucoma; Humans; I | 1976 |
The effects of drugs on Onchocerca volvulus. 3. Trials of suramin at different dosages and a comparison of the brands Antrypol, Moranyl and Naganol.
Topics: Clinical Trials as Topic; Humans; Onchocerca; Onchocerciasis; Suramin | 1968 |
The intake and transmissibility of Onchocerca volvulus microfilariae by Simulium damnosum fed on patients treated with Diethylcarbamazine, suramin or Mel W.
Topics: Arsenicals; Cameroon; Carrier State; Clinical Trials as Topic; Diethylcarbamazine; Diptera; Humans; | 1968 |
Experiments on the chemoprophylaxis of Onchocerca volvulus infection.
Topics: Animals; Arsenicals; Cameroon; Clinical Trials as Topic; Diethylcarbamazine; Hominidae; Humans; Onch | 1968 |
63 other studies available for suramin and Onchocerciasis
| Article | Year |
|---|---|
[Therapy of onchocerciasis, present use of specific drugs, suramins and diethylcarbamazine].
Topics: Diethylcarbamazine; Humans; Onchocerciasis; Suramin | 1953 |
The treatment of onchocerciasis with small doses of antrypol.
Topics: Humans; Onchocerciasis; Suramin | 1954 |
Severe onchocercal dermatosis responding to suramin and diethylcarbamazine: an illustrative case.
Topics: Diethylcarbamazine; Humans; Onchocerciasis; Skin Diseases; Suramin | 1954 |
Studies in onchocerciasis. III. The combined use of hetrazan and antrypol (Suramin B.P.) in the treatment of African onchocerciasis.
Topics: Black People; Diethylcarbamazine; Humans; Onchocerciasis; Suramin | 1954 |
Onchocerciasis; incubation period, clinical course, and treatment at first hand.
Topics: Diethylcarbamazine; Hand; Humans; Onchocerciasis; Suramin | 1955 |
A preliminary report on the out-patient treatment of onchocerciasis with antrypol in the West Nile District of Uganda.
Topics: Humans; Onchocerciasis; Outpatients; Suramin; Uganda | 1955 |
Effect of antrypol treatment on blindness due to onchocerciasis.
Topics: Blindness; Humans; Onchocerciasis; Suramin | 1956 |
Chemotherapy of onchocerciasis.
Topics: Anthelmintics; Humans; Onchocerciasis; Suramin | 1958 |
The treatment of onchocerciasis.
Topics: Anthelmintics; Humans; Onchocerciasis; Suramin | 1960 |
OBSERVATIONS ON THE TREATMENT OF ONCHOCERCIASIS IN AN ENDEMIC AREA OF WESTERN NIGERIA.
Topics: Complement Fixation Tests; Diagnosis; Diethylcarbamazine; Drug Therapy; Eosinophils; Epidemiology; H | 1964 |
[PARTIAL ACCOUNT (752 CASES) OF THE TREATMENT OF ONCHOCERCIASIS IN VENEZUELA WITH SURAMIN SODIUM].
Topics: Drug Therapy; Epidemiology; Humans; Onchocerciasis; Suramin; Venezuela | 1964 |
Treatment of wuchereriasis and onchocerciasis with suramin sodium.
Topics: Animals; Filariasis; Humans; Onchocerciasis; Sodium; Suramin; Wuchereria | 1955 |
[Pilot project for a medical treatment campaign against onchocerciasis based upon the administration of suramin sodium (USP XIII). I. Pretreatment survey].
Topics: Data Collection; Humans; Onchocerciasis; Pilot Projects; Suramin | 1955 |
[Pilot project for a medical treatment campaign against onchocerciasis based upon the administration of suramin sodium (U.S. P. XIII). II. Treatment and follow-up examination].
Topics: Follow-Up Studies; Humans; Onchocerciasis; Pilot Projects; Suramin | 1955 |
Experimental therapy of onchocerciasis with suramin and hetrazan; results of a three-year study.
Topics: Diethylcarbamazine; Onchocerciasis; Suramin; Therapies, Investigational | 1951 |
Antrypol in the treatment of onchocerciasis.
Topics: Humans; Onchocerciasis; Suramin | 1952 |
Recent developments in the treatment of onchocerciasis.
Topics: Antiprotozoal Agents; Benzimidazoles; Diethylcarbamazine; Humans; Ivermectin; Lactones; Onchocercias | 1984 |
[Onchocerciasis].
Topics: Animals; Diethylcarbamazine; Female; Humans; Male; Microfilariae; Onchocerciasis; Suramin | 1984 |
[Treatment of onchocerciasis with low, increasing doses of suramin in hyperendemic communities of Western Africa: 2. Clinical parasitologic and ophthalmologic results in a zone where transmission is controlled].
Topics: Adolescent; Adult; Burkina Faso; Child; Child, Preschool; Eye Diseases; Female; Humans; Infant; Infa | 1984 |
The six diseases of WHO. Onchocerciasis.
Topics: Adult; Africa, Western; Diethylcarbamazine; Humans; Insect Control; Insect Vectors; Onchocerciasis; | 1981 |
Onchocerciasis.
Topics: Adolescent; Adult; Diethylcarbamazine; Female; Humans; Insect Vectors; Male; Nigeria; Onchocerciasis | 1983 |
[Treatment of onchocerciasis in hyperendemic communities in West Africa with small, gradually increasing doses of suramin. 1. Parasitological results and ophthalmological surveillance in a region where transmission has not been interrupted].
Topics: Adult; Africa, Western; Disease Outbreaks; Eye; Female; Humans; Male; Middle Aged; Onchocerciasis; S | 1980 |
Management of onchocerciasis. Personal observations.
Topics: Conjunctivitis; Diethylcarbamazine; Humans; Lung Diseases, Parasitic; Lymphatic Diseases; Onchocerci | 1982 |
Basis for treatment and prevention of ocular onchocerciasis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Child; Child, Preschool; Diethylcarbamazine; Drug Therap | 1982 |
[Basis of the treatment and prevention of ocular onchocerciasis].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Africa; Antinematodal Agents; Diethylcarbamazine; Drug T | 1982 |
Review, after 3 years of the treatment with suramine, of a village suffering from onchocerciasis under entomological protection.
Topics: Adolescent; Adult; Burkina Faso; Female; Humans; Longitudinal Studies; Male; Middle Aged; Onchocerci | 1980 |
Onchocerciasis--chemotherapy: a risk-approach.
Topics: Animals; Diethylcarbamazine; Humans; Insect Vectors; Onchocerciasis; Pest Control; Prognosis; Public | 1981 |
Analysis of enzymatically isolated adults of Onchocerca volvulus after treatment of patients with suramin or metrifonate.
Topics: Animals; Female; Humans; Male; Onchocerca; Onchocerciasis; Suramin; Trichlorfon | 1980 |
The entry of ivermectin and suramin into Onchocerca ochengi nodules.
Topics: Animals; Cattle; Cattle Diseases; Female; Filaricides; Ivermectin; Onchocerciasis; Suramin | 1997 |
Animal models--Onchocerca ochengi and the development of chemotherapeutic and chemoprophylactic agents for onchocerciasis.
Topics: Animals; Cattle; Disease Models, Animal; Filaricides; Ivermectin; Microfilariae; Onchocerca; Onchoce | 1998 |
Evolution of a disease.
Topics: Animals; Diethylcarbamazine; Filaricides; Guatemala; History, 20th Century; Humans; Insect Vectors; | 1999 |
[Filariasis in patients returned from the tropics. Studies on 64 cases].
Topics: Adult; Africa, Western; Diethylcarbamazine; Drug Eruptions; Eosinophilia; Female; Filariasis; Humans | 1976 |
Ocular onchocerciasis.
Topics: Diethylcarbamazine; Drug Therapy, Combination; Eye Diseases; Humans; Insect Control; Onchocerciasis; | 1978 |
The risk of optic atrophy following suramin treatment of ocular onchocerciasis.
Topics: Eye Diseases; Female; Humans; Male; Onchocerciasis; Optic Atrophy; Suramin | 1979 |
An evaluation of the bovine -- Onchocerca gibsoni, Onchocerca gutturosa model as a tertiary screen for drugs against Onchocerca volvulus in man.
Topics: Animals; Cattle; Diethylcarbamazine; Disease Models, Animal; Drug Therapy, Combination; Filaricides; | 1979 |
[Therapy of ocular onchocerciasis].
Topics: Anthelmintics; Diethylcarbamazine; Eye Diseases; Filaricides; Humans; Keratitis; Onchocerciasis; Sur | 1979 |
Further observations on the relationship between ocular onchocerciasis and the head nodule, and on the possible benefit of nodulectomy.
Topics: Cameroon; Dermatologic Surgical Procedures; Diethylcarbamazine; Eye; Eye Diseases; Female; Head; Hum | 1978 |
Further observations on the relationship between ocular onchocerciasis and the head nodule, and on the possible benefit of nodulectomy.
Topics: Cameroon; Dermatologic Surgical Procedures; Diethylcarbamazine; Eye; Eye Diseases; Female; Head; Hum | 1978 |
Further observations on the relationship between ocular onchocerciasis and the head nodule, and on the possible benefit of nodulectomy.
Topics: Cameroon; Dermatologic Surgical Procedures; Diethylcarbamazine; Eye; Eye Diseases; Female; Head; Hum | 1978 |
Further observations on the relationship between ocular onchocerciasis and the head nodule, and on the possible benefit of nodulectomy.
Topics: Cameroon; Dermatologic Surgical Procedures; Diethylcarbamazine; Eye; Eye Diseases; Female; Head; Hum | 1978 |
Further studies on the treatment of ocular onchocerciasis with diethylcarbamazine and suramin.
Topics: Adolescent; Adult; Betamethasone; Child; Diethylcarbamazine; Drug Therapy, Combination; Eye Diseases | 1978 |
[Preventive measures and treatment of onchocerciasis].
Topics: Administration, Oral; Anthelmintics; Body Weight; Diethylcarbamazine; Dose-Response Relationship, Dr | 1977 |
The natural history of ocular onchocerciasis over a period of 14--15 years and the effect on this of a single course of suramin therapy.
Topics: Adolescent; Adult; Child; Eye Diseases; Female; Follow-Up Studies; Humans; Male; Microfilariae; Onch | 1976 |
Histopathological studies on suramin toxicity in a chimpanzee.
Topics: Animals; Female; Intestines; Kidney; Liver; Lymph Nodes; Onchocerciasis; Organ Specificity; Pan trog | 1977 |
Microfilariae in the cerebrospinal fluid, and neurological complications, during treatment of onchocerciasis with diethylcarbamazine.
Topics: Arachnoid; Blood-Brain Barrier; Cerebrospinal Fluid; Choroid Plexus; Diethylcarbamazine; Female; Hum | 1976 |
The populatin dynamics of Onchocerca volvulus microfilariae during treatment with suramin and diethylcarbamazine.
Topics: Anterior Chamber; Diethylcarbamazine; Humans; Liver; Liver Circulation; Onchocerca; Onchocerciasis; | 1976 |
Suramin and therapy of onchocerciasis.
Topics: Humans; Onchocerciasis; Suramin | 1992 |
Suramin and the time it takes to kill Onchocerca volvulus.
Topics: Adult; Animals; Female; Humans; Male; Microfilariae; Onchocerca; Onchocerciasis; Skin; Suramin; Time | 1991 |
Histological examination of adult Onchocerca volvulus and comparison with the collagenase technique.
Topics: Aging; Animals; Female; Filaricides; Humans; Male; Microbial Collagenase; Microfilariae; Microscopy, | 1988 |
Suramin and eosinophil degranulation and vacuolation in onchocerciasis.
Topics: Adult; Cytoplasmic Granules; Eosinophils; Female; Humans; Lysosomes; Onchocerciasis; Suramin | 1987 |
On the treatment of onchocerciasis in Sudan.
Topics: Diethylcarbamazine; Female; Humans; Male; Onchocerciasis; Skin Pigmentation; Sudan; Suramin | 1985 |
Determination of suramin in plasma by high-performance liquid chromatography.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Onchocerciasis; Suramin; Time Factors | 1985 |
Suramin in the treatment of onchocerciasis: the efficacy of low doses on the parasite in an area with vector control.
Topics: Animals; Burkina Faso; Humans; Insect Control; Insect Vectors; Mali; Microfilariae; Onchocerca; Onch | 1985 |
Effect of diethylcarbamazine and suramin on Onchocerca volvulus microfilariae in urine.
Topics: Adolescent; Adult; Aged; Diethylcarbamazine; Humans; Methods; Middle Aged; Onchocerca; Onchocerciasi | 1973 |
[Onchocerciasis in Mexico].
Topics: Animals; Atrophy; Chorioretinitis; Culicidae; Diethylcarbamazine; Ecology; Geography; Humans; Insect | 1974 |
[The therapeutic difficulties of ocular onchocerciasis].
Topics: Arsenicals; Diethylcarbamazine; Eye Diseases; Humans; Onchocerciasis; Optic Nerve; Suramin; Thiabend | 1969 |
[Onchocerciasis imported in the Netherlands; a review of 100 cases].
Topics: Adolescent; Adult; Cameroon; Child; Child, Preschool; Diethylcarbamazine; Female; Humans; Male; Midd | 1973 |
The effect of suramin on the immature forms of Onchocerca volvulus in the vertebrate host.
Topics: Africa, Western; Animals; Drug Evaluation; Humans; Injections, Intravenous; Onchocerca; Onchocercias | 1974 |
Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 4. The prophylactic and suppressive activity of suramin.
Topics: Animals; Diethylcarbamazine; Disease Models, Animal; Female; Humans; Injections, Intradermal; Male; | 1974 |
Suramin induced amino-aciduria.
Topics: Humans; Onchocerciasis; Phosphates; Proteinuria; Renal Aminoacidurias; Suramin | 1972 |
Onchocerciasis (ocular).
Topics: Biopsy; Child; Diagnosis, Differential; Diethylcarbamazine; Diphenhydramine; Eye Diseases; Female; H | 1971 |
Reinfections with Onchocerca volvulus in cured patients exposed to continuing transmission.
Topics: Adult; Antimony; Cameroon; Humans; Male; Middle Aged; Onchocerciasis; Suramin | 1968 |
[Onchocerciasis in the Congo].
Topics: Adolescent; Adult; Child; Child, Preschool; Congo; Diptera; Female; Humans; Infant; Insect Vectors; | 1969 |
[Eye involvement in onchocerciasis].
Topics: Adult; Biopsy; Complement Fixation Tests; Cornea; Diagnosis, Differential; Diethylcarbamazine; Eye D | 1967 |
[Clinical and histological evaluation of the treatment of a clinical case of onchocerciasis with antrypol and hetrazan].
Topics: Adult; Biopsy; Diagnosis, Differential; Diethylcarbamazine; Humans; Male; Onchocerciasis; Suramin | 1967 |
Onchocerciasis.
Topics: Africa; Central America; Diagnosis, Differential; Diethylcarbamazine; Eye Manifestations; Humans; On | 1968 |