mebendazole has been researched along with Onchocerciasis in 23 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
Onchocerciasis: Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flubendazole, an injectable benzimidazole drug, was compared with diethylcarbamazine (DEC) in a prospective double-blind study of the treatment of onchocerciasis." | 9.05 | Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis. ( Beltran-Hernandez, F; Dominguez-Vazquez, A; Greene, BM; Murphy, RP; Rivas-Alcala, AR; Ruvalcaba-Macias, AM; Taylor, HR, 1983) |
| "Mebendazole was compared to placebo treatment in a prospective double-masked study of the treatment of onchocerciasis." | 9.05 | Fluorescein angiographic studies of mebendazole treatment for onchocerciasis. ( Awadzi, K; George, T; Murphy, RP; Schulz-Key, H; Taylor, HR, 1985) |
| "Increasing concentrations of levamisole and of mebendazole were applied to 1 eye in groups of 4 patients with ocular onchocerciasis in northern Cameroon." | 9.04 | Evaluation of microfilaricidal effects in the cornea from topically applied drugs in ocular onchocerciasis: Trials with levamisole and mebendazole. ( Anderson, J; Fuglsang, H; Jones, BR, 1978) |
| "Four drug regimens for treating onchocerciasis were compared in a double-blind study in persons from an endemic area in southern Mexico." | 6.65 | Chemotherapy of onchocerciasis: a controlled comparison of mebendazole, levamisole, and diethylcarbamazine. ( Beltrán, F; Domíguez-Vázquez, A; Greene, BM; Lugo-Pfeiffer, C; Mackenzie, CD; Rivas-Alcalá, AR; Ruvalcaba-Macías, AM; Taylor, HR, 1981) |
| "Flubendazole, an injectable benzimidazole drug, was compared with diethylcarbamazine (DEC) in a prospective double-blind study of the treatment of onchocerciasis." | 5.05 | Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis. ( Beltran-Hernandez, F; Dominguez-Vazquez, A; Greene, BM; Murphy, RP; Rivas-Alcala, AR; Ruvalcaba-Macias, AM; Taylor, HR, 1983) |
| "Mebendazole was compared to placebo treatment in a prospective double-masked study of the treatment of onchocerciasis." | 5.05 | Fluorescein angiographic studies of mebendazole treatment for onchocerciasis. ( Awadzi, K; George, T; Murphy, RP; Schulz-Key, H; Taylor, HR, 1985) |
| "Increasing concentrations of levamisole and of mebendazole were applied to 1 eye in groups of 4 patients with ocular onchocerciasis in northern Cameroon." | 5.04 | Evaluation of microfilaricidal effects in the cornea from topically applied drugs in ocular onchocerciasis: Trials with levamisole and mebendazole. ( Anderson, J; Fuglsang, H; Jones, BR, 1978) |
| "The current mainstay for control/elimination of onchocerciasis and soil-transmitted helminthiasis (STH) relies on ivermectin- and mebendazole/albendazole-based preventive chemotherapies." | 4.12 | High infection rates for onchocerciasis and soil-transmitted helminthiasis in children under five not receiving preventive chemotherapy: a bottleneck to elimination. ( Balog, YA; Bopda, JG; Djune-Yemeli, L; Domche, A; Donfo-Azafack, C; Efon-Ekangouo, A; Kamgno, J; Lenou-Nanga, C; Mbickmen-Tchana, S; Nana-Djeunga, HC; Ntoumi, F; Nzune-Toche, N; Penlap-Beng, V; Velavan, TP, 2022) |
| "Albendazole has no microfilaricidal activity but is toxic to all intra-uterine stages." | 3.78 | Research notes from the Onchocerciasis Chemotherapy Research Centre, Ghana. ( Awadzi, K, 1997) |
| "Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine." | 2.61 | Flubendazole as a macrofilaricide: History and background. ( Geary, TG; Mackenzie, CD; Silber, SA, 2019) |
| "loa L3 and treated with 10 mg/kg FLBZ once daily for 5 consecutive days." | 1.51 | Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents. ( Chunda, VC; Enyong, P; Fombad, FF; Gandjui, NVT; Hoerauf, A; Mackenzie, CD; Metuge, HM; Ndongmo, PC; Njiokou, F; Njouendou, AJ; Ritter, M; Wanji, S, 2019) |
| " Systemic exposures of FBZ/FBZ metabolites achieved following dosing were measured by pharmacokinetic (PK) bioanalysis." | 1.51 | Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models. ( Akumtoh, DN; Aljayyoussi, G; Baeten, B; Chounna, PWN; Chunda, VC; Engelen, M; Fombad, FF; Gandjui, NVT; Lachaud, S; Metuge, HM; Ndzeshang, BL; Njouendou, AJ; Pionnier, N; Quirynen, L; Sjoberg, HT; Steven, A; Taylor, MJ; Tayong, DB; Tekle, F; Turner, JD; Wanji, S; Ward, SA, 2019) |
| "Onchocerciasis is co-endemic with schistosomiasis and intestinal helminths infections, which are all diseases of the rural and the poorest communities in Africa." | 1.32 | Integrated community-directed treatment for the control of onchocerciasis, schistosomiasis and intestinal helminths infections in Uganda: advantages and disadvantages. ( Kabatereine, N; Ndyomugyenyi, R, 2003) |
| "Treatment with levamisole had a similar effect on embryogenesis, however it was much less marked." | 1.27 | The effects of diethylcarbamazine, mebendazole and levamisole on Onchocerca volvulus in vivo and in vitro. ( Gomez-Rojo, E; Greene, BM; Mackenzie, CD; Rivas-Alcala, R; Taylor, HR, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (56.52) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Nana-Djeunga, HC | 1 |
| Djune-Yemeli, L | 1 |
| Domche, A | 1 |
| Donfo-Azafack, C | 1 |
| Efon-Ekangouo, A | 1 |
| Lenou-Nanga, C | 1 |
| Nzune-Toche, N | 1 |
| Balog, YA | 1 |
| Bopda, JG | 1 |
| Mbickmen-Tchana, S | 1 |
| Velavan, TP | 1 |
| Penlap-Beng, V | 1 |
| Ntoumi, F | 1 |
| Kamgno, J | 1 |
| Fombad, FF | 2 |
| Njouendou, AJ | 2 |
| Ndongmo, PC | 1 |
| Ritter, M | 1 |
| Chunda, VC | 2 |
| Metuge, HM | 2 |
| Gandjui, NVT | 2 |
| Enyong, P | 1 |
| Njiokou, F | 1 |
| Hoerauf, A | 1 |
| Mackenzie, CD | 5 |
| Wanji, S | 2 |
| Sjoberg, HT | 1 |
| Pionnier, N | 1 |
| Aljayyoussi, G | 1 |
| Tayong, DB | 1 |
| Akumtoh, DN | 1 |
| Chounna, PWN | 1 |
| Ndzeshang, BL | 1 |
| Lachaud, S | 1 |
| Tekle, F | 1 |
| Quirynen, L | 1 |
| Engelen, M | 1 |
| Baeten, B | 1 |
| Steven, A | 1 |
| Ward, SA | 1 |
| Taylor, MJ | 1 |
| Turner, JD | 1 |
| Geary, TG | 2 |
| Silber, SA | 1 |
| Cho-Ngwa, F | 1 |
| Mbah, GE | 1 |
| Ayiseh, RB | 1 |
| Ndi, EM | 1 |
| Monya, E | 1 |
| Tumanjong, IM | 1 |
| Mainsah, EN | 1 |
| Sakanari, J | 1 |
| Lustigman, S | 1 |
| Ndyomugyenyi, R | 1 |
| Kabatereine, N | 1 |
| Rivas-Alcalá, AR | 3 |
| Greene, BM | 4 |
| Taylor, HR | 5 |
| Domíguez-Vázquez, A | 1 |
| Ruvalcaba-Macías, AM | 3 |
| Lugo-Pfeiffer, C | 2 |
| Beltrán, F | 1 |
| Domiguez-Vaques, A | 1 |
| Beltran-Hernandez, F | 2 |
| Dominguez-Vazquez, A | 1 |
| Murphy, RP | 2 |
| Rivas-Alcala, R | 1 |
| Gomez-Rojo, E | 1 |
| Forsyth, KP | 1 |
| Mitchell, GF | 1 |
| Copeman, DB | 1 |
| Kale, OO | 1 |
| Awadzi, K | 4 |
| Schulz-Key, H | 3 |
| Howells, RE | 1 |
| Haddock, DR | 1 |
| Gilles, HM | 1 |
| Rolland, A | 1 |
| Thylefors, B | 1 |
| Strote, G | 1 |
| Bonow, I | 1 |
| Krömer, M | 1 |
| Rubio de Krömer, T | 1 |
| Attah, S | 1 |
| Opoku, N | 1 |
| Coperman, DB | 1 |
| Kale, O | 1 |
| Jones, BR | 1 |
| Anderson, J | 1 |
| Fuglsang, H | 1 |
| Maertens, K | 1 |
| Wéry, M | 1 |
| Edwards, G | 1 |
| Breckenridge, A | 1 |
| Orme, M | 1 |
| Gilles, H | 1 |
| George, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Single Dose Treatment With Diethylcarbamazine, Albendazole and Ivermectin in Humans With and Without Wuchereria Bancrofti Infection in Côte d'Ivoire[NCT02845713] | Phase 1 | 66 participants (Actual) | Interventional | 2016-04-17 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mebendazole and Onchocerciasis
| Article | Year |
|---|---|
Flubendazole as a macrofilaricide: History and background.
Topics: Albendazole; Animals; Diethylcarbamazine; Elephantiasis, Filarial; Filaricides; Gastrointestinal Dis | 2019 |
Research notes from the Onchocerciasis Chemotherapy Research Centre, Ghana.
Topics: Albendazole; Animals; Filaricides; Humans; Ivermectin; Mebendazole; Onchocerca volvulus; Onchocercia | 1997 |
10 trials available for mebendazole and Onchocerciasis
| Article | Year |
|---|---|
Chemotherapy of onchocerciasis: a controlled comparison of mebendazole, levamisole, and diethylcarbamazine.
Topics: Adolescent; Adult; Aged; Benzimidazoles; Clinical Trials as Topic; Diethylcarbamazine; Double-Blind | 1981 |
12 month follow-up of mebendazole therapy for onchocerciasis.
Topics: Benzimidazoles; Clinical Trials as Topic; Follow-Up Studies; Humans; Male; Mebendazole; Onchocercias | 1981 |
Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis.
Topics: Adolescent; Adult; Antinematodal Agents; Benzimidazoles; Child; Clinical Trials as Topic; Diethylcar | 1983 |
Further trials of mebendazole and metrifonate in the treatment of onchocerciasis.
Topics: Adult; Benzimidazoles; Clinical Trials as Topic; Female; Humans; Male; Mebendazole; Middle Aged; Onc | 1982 |
The chemotherapy of onchocerciasis VIII Levamisole and its combination with the benzimidazoles.
Topics: Adolescent; Adult; Antinematodal Agents; Benzimidazoles; Drug Therapy, Combination; Humans; Levamiso | 1982 |
Research notes from the Onchocerciasis Chemotherapy Research Centre, Ghana.
Topics: Albendazole; Animals; Filaricides; Humans; Ivermectin; Mebendazole; Onchocerca volvulus; Onchocercia | 1997 |
Small-scale trials of six drugs against Onchocerca volvulus.
Topics: Adult; Aged; Anthelmintics; Drug Evaluation; Female; Filaricides; Humans; Male; Mebendazole; Metroni | 1978 |
Evaluation of microfilaricidal effects in the cornea from topically applied drugs in ocular onchocerciasis: Trials with levamisole and mebendazole.
Topics: Cornea; Dose-Response Relationship, Drug; Eye Diseases; Humans; Levamisole; Mebendazole; Onchocerca; | 1978 |
The chemotherapy of onchocerciasis. XIV. Studies with mebendazole citrate.
Topics: Adult; Animals; Drug Therapy, Combination; Female; Humans; Levamisole; Male; Mebendazole; Microfilar | 1990 |
Fluorescein angiographic studies of mebendazole treatment for onchocerciasis.
Topics: Adult; Benzimidazoles; Eye Diseases; Fluorescein Angiography; Ghana; Humans; Levamisole; Male; Meben | 1985 |
12 other studies available for mebendazole and Onchocerciasis
| Article | Year |
|---|---|
High infection rates for onchocerciasis and soil-transmitted helminthiasis in children under five not receiving preventive chemotherapy: a bottleneck to elimination.
Topics: Albendazole; Animals; Child; Child, Preschool; Cross-Sectional Studies; Female; Helminthiasis; Human | 2022 |
Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents.
Topics: Africa, Central; Africa, Western; Animals; Cell Line; Elephantiasis, Filarial; Filaricides; Hydrolys | 2019 |
Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.
Topics: Administration, Oral; Animals; Brugia malayi; Disease Models, Animal; Filaricides; Ivermectin; Male; | 2019 |
Development and validation of an Onchocerca ochengi adult male worm gerbil model for macrofilaricidal drug screening.
Topics: Animals; Benzimidazoles; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Filaricides; | 2019 |
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Anthelmintics; beta-Cyclodextrins; Brugia; Chemistry, Ph | 2011 |
Integrated community-directed treatment for the control of onchocerciasis, schistosomiasis and intestinal helminths infections in Uganda: advantages and disadvantages.
Topics: Adolescent; Anthelmintics; Child; Child, Preschool; Community Health Services; Decision Making; Feas | 2003 |
The effects of diethylcarbamazine, mebendazole and levamisole on Onchocerca volvulus in vivo and in vitro.
Topics: Animals; Benzimidazoles; Culture Media; Diethylcarbamazine; Humans; Levamisole; Male; Mebendazole; M | 1984 |
Onchocerca gibsoni: increase of circulating egg antigen with chemotherapy in bovines.
Topics: Animals; Anthelmintics; Antibodies, Monoclonal; Antigens, Surface; Cattle; Diethylcarbamazine; Femal | 1984 |
Basis for treatment and prevention of ocular onchocerciasis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Child; Child, Preschool; Diethylcarbamazine; Drug Therap | 1982 |
Chemotherapy for onchocerciasis: results of in vitro experiments with promising new compounds.
Topics: Animals; Antinematodal Agents; Dose-Response Relationship, Drug; Female; Male; Mebendazole; Onchocer | 1998 |
An evaluation of the bovine -- Onchocerca gibsoni, Onchocerca gutturosa model as a tertiary screen for drugs against Onchocerca volvulus in man.
Topics: Animals; Cattle; Diethylcarbamazine; Disease Models, Animal; Drug Therapy, Combination; Filaricides; | 1979 |
Effect of mebendazole and levamisole on Onchocerca volvulus and Dipetalonema perstans.
Topics: Adult; Benzimidazoles; Democratic Republic of the Congo; Dipetalonema; Dipetalonema Infections; Dose | 1975 |