cytochrome-c-t and Crush-Syndrome

Experiments on rats showed that traumatic toxicosis (crush syndrome) was accompanied by disorders of both excretion and detoxication functions of the liver and a decrease in the energy potential of the liver. Systemic administration of cytochrome C (10 mg/kg) immediately after trauma and decompression increased the level of endogenous cytochrome C, recovered the pool of adenine nucleotides, normalized bromsulfaleine excretion from the blood, and decreased the content of toxic metabolites in the blood. The obtained experimental data show that cytochrome C possesses high hepatoprotective properties with respect to the development of traumatic toxicosis.

Topics: Adenine Nucleotides; Animals; Crush Syndrome; Cytochromes c; Disease Models, Animal; Injections, Intraperitoneal; Liver; Liver Function Tests; Male; Oxidative Phosphorylation; Protective Agents; Rats; Rats, Wistar; Sulfobromophthalein