flavin-mononucleotide and Crush-Syndrome

Experiments on rats showed that traumatic toxicosis (crush syndrome) was accompanied with hypotension, bradycardia, reduction in temperature, breath frequency, and oxygen intake, and violation of acid-base buffer state with elevation of lactate acidosis in the blood serum that is typical of shock performance. Substrate combined antihypoxant cytoflavine (1.5 ml/kg) administered systemically to rats immediately after decompression, increased percentage of survived rats and recovered the main indexes of functional systems and acid-base buffer state 12 h after trauma, which provided general protection of rats against traumatic toxicosis.

Topics: Animals; Blood Circulation; Blood Pressure; Crush Syndrome; Drug Combinations; Flavin Mononucleotide; Inosine Diphosphate; Lactic Acid; Male; Niacinamide; Oxygen Consumption; Pyruvic Acid; Rats; Respiration; Succinates; Time Factors; Water-Electrolyte Balance