morphine and Megacolon

Topics: Abnormalities, Multiple; Colonic Diseases; Digestive System Abnormalities; Duodenal Obstruction; Esophageal Atresia; Female; Hernia; Humans; Ileum; Infant, Newborn; Intestinal Atresia; Intestinal Obstruction; Intestines; Jejunum; Male; Meconium; Megacolon; Mesenteric Cyst; Polyhydramnios; Pregnancy; Pylorus; Radiography; Vitelline Duct

Topics: Birth Weight; Diagnosis, Differential; Humans; Infant Food; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Meconium; Megacolon; Therapeutic Irrigation

Topics: Anal Canal; Congenital Abnormalities; Cystic Fibrosis; Duodenal Obstruction; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Atresia; Intestinal Obstruction; Meconium; Megacolon; Pancreas; Rectum

The diagnosis of Hirschsprung's disease is at times difficult, particularly in the young patient. Since 1972 we have used rectal suction biopsy as a screening technique in neonates and infants with failure to pass meconium or evidence of obstruction. In addition, it is used to confirm the diagnosis of Hirschsprung's disease when suspected by barium enema study. This technique has been used in 444 patients, 302 of whom were less than one year of age. No anesthesia is necessary, and there have been no associated complications. Only one patient early in the study had an initial misdiagnosis. There have been no false-positive or false-negative specimens since this initial problem, and no patients have undergone inappropriate pull-through procedures for suspected Hirschsprung's disease. It is recommended that all neonates who do not pass meconium in the first 48 hours of life undergo rectal suction biopsy to establish the diagnosis of congenital megacolon.

Topics: Biopsy, Needle; Child; Child, Preschool; Diagnosis, Differential; Evaluation Studies as Topic; Humans; Infant; Infant, Newborn; Intestinal Obstruction; Meconium; Megacolon; Rectum

Topics: Cystic Fibrosis; Esophageal Atresia; Humans; Infant, Newborn; Intestinal Obstruction; Intestines; Meconium; Megacolon; Prognosis

Topics: Digestive System; Digestive System Abnormalities; Duodenum; Enterocolitis, Pseudomembranous; Gastrointestinal Diseases; Hernia, Umbilical; Humans; Infant, Newborn; Intestinal Obstruction; Meckel Diverticulum; Meconium; Megacolon

Topics: Cystic Fibrosis; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Meconium; Megacolon; Syndrome

The meconium plug syndrome (MPS) is a common cause of low intestinal obstruction in newborn infants. Usually, it is benign and not associated with other intestinal dysfunction. We describe the cases of three infants in whom there was intestinal obstruction consistent with the MPS and in which cystic fibrosis (CF) was later documented. We suggest that there is an association between the MPS and CF, and that the condition of all infants with the MPS be evaluated for the possibility of both Hirschsprung's disease and CF.

Topics: Cystic Fibrosis; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Male; Meconium; Megacolon; Radiography; Syndrome

Neonatal small left colon syndrome is a cause of functional colon obstruction in newborn infants, with a high association of maternal diabetes. There has been much confusion regarding its relationship to meconium plug syndrome and aganglionosis. Six cases of aganglionosis (2 in infants of diabetic mothers) were encountered in which the radiographic findings were identical to small left colon syndrome, indicating the need for caution in dismissing aganglionosis solely on the basis of a small left colon seen radiographically in a newborn infant with colon obstruction. Small left colon and meconium plug syndrome are overlapping entities in the total spectrum of functional intestinal obstruction in newborn infants.

Topics: Adolescent; Adult; Colon; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Male; Meconium; Megacolon; Pregnancy; Pregnancy in Diabetics; Radiography; Syndrome

Topics: Colonic Diseases, Functional; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Intestinal Obstruction; Meconium; Megacolon; Pregnancy; Pregnancy in Diabetics; Radiography

Topics: Diagnosis, Differential; Enterocolitis, Pseudomembranous; Female; Humans; Infant, Newborn; Intestinal Obstruction; Jejunum; Male; Meconium; Megacolon; Radiography

Topics: Appendicitis; Barium Sulfate; Constipation; Diverticulum; Duodenal Diseases; Duodenal Obstruction; Duodenum; Enema; Humans; Ileum; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Atresia; Intestinal Obstruction; Intestine, Small; Meconium; Megacolon; Preoperative Care; Radiography; Syndrome

Topics: Abdomen; Adolescent; Anemia; Child; Child, Preschool; Constipation; Diagnosis, Differential; Female; Guaiac; Humans; Infant, Newborn; Male; Meconium; Megacolon; Melena; Neuromuscular Diseases; Pain; Pediatrics; Posture; Rectal Diseases; Rectum; Sigmoidoscopy; Urethral Diseases; Vaginal Diseases

Topics: Barium Sulfate; Colon; Colonic Diseases; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Male; Meconium; Megacolon; Radiography

Topics: Colonic Diseases; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Male; Meconium; Megacolon; Radiography

Topics: Ileum; Intestinal Obstruction; Intestine, Small; Meckel Diverticulum; Meconium; Megacolon

Topics: Defecation; Humans; Infant, Newborn; Meconium; Megacolon; Myenteric Plexus; Neurons

Topics: Adolescent; Age Factors; Barium Sulfate; Biopsy; Birth Weight; Child; Child, Preschool; Constipation; Enema; Female; Humans; Infant; Infant, Newborn; Male; Meconium; Megacolon

Topics: Anal Canal; Body Fluids; Body Water; Body Weight; Deuterium; Duodenum; Esophageal Atresia; Hernia, Umbilical; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Atresia; Intestinal Obstruction; Jejunum; Meconium; Megacolon; Radioisotope Dilution Technique; Rectum; Tracheoesophageal Fistula; Water

Topics: Colostomy; Defecation; Humans; Infant, Newborn; Male; Meconium; Megacolon

Topics: Barium Sulfate; Colon; Enema; Female; France; Ganglia, Autonomic; Humans; Ileostomy; Infant, Newborn; Intestinal Obstruction; Male; Meconium; Megacolon; Prognosis; Radiography; Sex Factors

Topics: Diagnosis, Differential; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Meconium; Megacolon; Radiography

Topics: Acetylcholinesterase; Biopsy; Constipation; Diagnosis, Differential; Diarrhea; Histocytochemistry; Humans; Infant; Infant, Newborn; Meconium; Megacolon; Radiography; Rectum

Topics: Biopsy; Down Syndrome; Humans; Infant, Newborn; Intestinal Obstruction; Jejunum; Meconium; Megacolon; Methods; United Kingdom

Topics: Diarrhea, Infantile; Humans; Infant, Newborn; Infant, Newborn, Diseases; Meconium; Megacolon; Radiography; Therapeutic Irrigation

Topics: Barium; Diagnosis, Differential; Enema; Humans; Ileum; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Atresia; Intestinal Diseases; Intestinal Obstruction; Intestine, Small; Meconium; Megacolon; Radiography

Topics: Duodenal Obstruction; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Intestine, Small; Meconium; Megacolon; Mesentery

Topics: Anal Canal; Barium Sulfate; Cecum; Child; Colitis; Colon; Diagnosis, Differential; Female; Fluoroscopy; Ganglia, Autonomic; Humans; Ileitis; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Male; Meconium; Megacolon; Rectal Diseases; Rectum

Topics: Catheterization; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infusions, Parenteral; Intestinal Obstruction; Male; Meconium; Megacolon; Pregnancy; Respiratory Distress Syndrome, Newborn; Sepsis; Umbilical Veins

Topics: Diagnosis, Differential; Enema; Female; Humans; Hypoxia, Brain; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Male; Meconium; Megacolon; Radiography

Topics: Barium Sulfate; Biopsy; Chymotrypsin; Diagnosis, Differential; Feces; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; Intestinal Obstruction; Intestine, Small; Male; Meconium; Megacolon; Radiography; Trypsin

Topics: Abdominal Muscles; Anus, Imperforate; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Intestinal Perforation; Intestines; Male; Meconium; Megacolon

Topics: Duodenal Obstruction; Humans; Infant; Intestinal Obstruction; Jejunum; Meconium; Megacolon; Posture; Radiography; Vomiting

A mass of inspissated meconium in the distal colon or rectum is a relatively common cause of neonatal intestinal obstruction. The meconium-plug syndrome is unrelated to cystic fibrosis and meconium ileus. The clinical picture is frequently indistinguishable, without contrast study of the colon, from other forms of mechanical intestinal obstruction requiring laparotomy. A barium enema examination is almost always diagnostic, and use of this procedure usually results in dislodgement and passage of the plug.No single cause for the excessive viscosity and tenaciousness of the obstructive meconium mass has been identified. Previous reports have generally emphasized the normal ganglion-cell content of the colon in affected patients.Two infants are described who fulfilled all criteria for this syndrome but who were not rendered asymptomatic, as normally anticipated, by removal of the plug. Subsequent studies revealed the presence of Hirschsprung's disease in both patients. This diagnosis should be considered when an infant with meconium-plug obstruction of the colon fails to follow the usual satisfactory clinical course after the plug has been passed.

Topics: Barium Sulfate; Colonic Diseases; Colostomy; Cystic Fibrosis; Enema; Fetal Diseases; Hirschsprung Disease; Humans; Ileus; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Laparotomy; Male; Meconium; Megacolon; Radiography; Rectum; Syndrome

Topics: Anal Canal; Anus, Imperforate; Congenital Abnormalities; Diagnosis; Gastrointestinal Diseases; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Meconium; Megacolon; Radiography

Topics: Diagnosis, Differential; Humans; Ileus; Infant, Newborn; Infant, Premature, Diseases; Intestinal Obstruction; Meconium; Megacolon; Radiography; Surgical Procedures, Operative

Topics: Colostomy; Diagnosis, Differential; Female; Humans; Ileostomy; Infant; Infant, Newborn; Intestinal Atresia; Intestine, Small; Intestines; Meconium; Megacolon; Polyhydramnios; Pregnancy; Pregnancy Complications; Prognosis; Surgical Procedures, Operative

Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Intestinal Perforation; Liver Diseases; Meconium; Megacolon; Peritonitis; Pseudomonas Infections; Radiography; Sepsis

Topics: Abdomen; Abdomen, Acute; Cystic Fibrosis; Gastrointestinal Diseases; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Atresia; Intestinal Obstruction; Meconium; Megacolon; Peritonitis; Surgical Procedures, Operative

Topics: Adrenal Insufficiency; Congenital Abnormalities; Cysts; Hernia, Umbilical; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Atresia; Intestinal Diseases; Intestinal Obstruction; Intussusception; Meconium; Megacolon; Mesenteric Vascular Occlusion; Pathology; Peritonitis; Surgical Procedures, Operative

Topics: Child; Fetal Diseases; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Meconium; Megacolon; Peritonitis

Topics: Hirschsprung Disease; Humans; Ileus; Infant, Newborn; Infant, Newborn, Diseases; Intestinal Obstruction; Meconium; Megacolon; Mesentery