Hydramnios

A condition of abnormally high AMNIOTIC FLUID volume, such as greater than 2,000 ml in the LAST TRIMESTER and usually diagnosed by ultrasonographic criteria (AMNIOTIC FLUID INDEX). It is associated with maternal DIABETES MELLITUS; MULTIPLE PREGNANCY; CHROMOSOMAL DISORDERS; and congenital abnormalities.

Synonym
Polyhydramnios
Hydramnios

Excerpt	Reference
"Our definition of hydramnios is an amniotic fluid index of 24 cm or greater."	( Carlson, DE; Medearis, AL; Platt, LD, 1992)
"Polyhydramnios is an uncommon cause of premature labor and delivery."	( Rodriguez, MH, 1992)
"Acute recurrent polyhydramnios is an extremely rare condition of unknown aetiology."	( Caruso, A; Cavaliere, AF; De Santis, M; Masini, L; Menini, E; Noia, G, 2000)

Excerpt	Reference
"A case of acute polyhydramnios for unknown reason was successfully treated with orally administrated indomethacin."	( Nordström, L; Westgren, M, 1992)
"Indomethacin is a powerful treatment for polyhydramnios but its use requires close monitoring of the fetal heart."	( D'Orsogna, L; Mohen, D; Newnham, JP, 1992)
"Fifteen patients with polyhydramnios and clinical symptoms related to excess amniotic fluid volume were treated with indomethacin therapy that was started at a mean gestational age of 27."	( Andreou, A; Assimakopoulos, E; Mamopoulos, M; Mantalenakis, S; Reece, EA; Zheng, XZ, 1990)
"A case of polyhydramnios was effectively treated with amniotic fluid decompression and indomethacin."	( Cotton, DB; Kirshon, B; Smith, LG, 1990)
"A case of recurrent acute polyhydramnios successfully treated with indomethacin is described."	( Faber, BL, 1990)
"Eight gravidas with symptomatic polyhydramnios were managed with maternal indomethacin therapy."	( Kirshon, B; Mari, G; Moise, KJ, 1990)
"Acute polyhydramnios due to twin to twin transfusion is a rare complication of twin pregnancies which, despite treatment, has a high perinatal mortality."	( Busby, G; Kuruvilla, A; Ramsewak, S, 2001)
"The presence of severe polyhydramnios of early onset with no identified cause should lead to suspicion of neonatal BS which even when infrequent determines severe hydroelectrolytic alterations and should be treated early."	( Caviedes R, N; Gómez de la F, CL; Novoa P, JM, 2019)
"The goiters shrunk and the polyhydramnios improved in response to the in utero treatment."	( Hidaka, N; Kitadai, Y; Nakanami, N; Sato, M; Soejima, C; Sumie, M, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	143 (46.43)	23.3326
1990's	84 (27.27)	12.5806
2000's	41 (13.31)	18.1394
2010's	34 (11.04)	28.8240
2020's	6 (1.95)	9.53

Drug	Relationship Strength	Studies	Trials
acetone	low	1	0
bromide	low	1	0
chlorine	low	18	0
salicylic acid	low	1	0
lactic acid	low	2	0
glycine	low	1	0
hydrogen carbonate	low	4	0
nitrous oxide	low	1	0
uric acid	low	2	0
urea	low	2	0
1-anilino-8-naphthalenesulfonate	low	1	0
acetaminophen	low	1	0
diatrizoic acid	low	1	0
p-aminohippuric acid	low	3	0
chlorothiazide	low	1	0
diazepam	low	1	0
ethacrynic acid	low	1	0
fentanyl	low	1	0
furosemide	low	2	0
ibuprofen	low	2	0
indomethacin	low	61	0
isoxsuprine	low	1	0
ketoprofen	low	1	0
meclizine	low	2	0
nafamostat	low	1	0
nifedipine	low	1	0
omeprazole	low	1	0
potassium chloride	low	2	0
pronethalol	low	1	0
propofol	low	1	0
pyrimethamine	low	1	0
sevoflurane	low	2	0
sulfadiazine	low	1	0
succinylcholine	low	1	0
sulfamethoxypyridazine	low	1	0
thalidomide	low	1	0
tolbutamide	low	1	0
estriol	low	17	0
hydroxyproline	low	1	0
thyroxine	low	13	0
aldosterone	low	4	0
dehydroepiandrosterone	low	1	0
triiodothyronine	low	1	0
alanine	low	1	0
serine	low	1	0
aspartic acid	low	1	0
sucrose	low	1	0
androstenedione	low	1	0
phenylalanine	low	2	0
ampicillin	low	1	0
asparagine	low	1	0
valine	low	1	0
ethylene oxide	low	1	0
pyridostigmine bromide	low	1	0
methylergonovine	low	1	0
phenformin	low	1	0
ambenonium chloride	low	1	0
betamethasone	low	4	0
carbonates	low	1	0
trimethaphan	low	1	0
tungsten	low	1	0
argon	low	1	0
gold	low	1	0
chromates	low	1	0
potassium chromate(vi)	low	1	0
ammonium chloride	low	1	0
urobilinogen	low	1	0
cephalexin	low	1	0
triamcinolone	low	1	0
fludrocortisone	low	1	0
4-methoxyamphetamine	low	1	0
du-21220	medium	1	1
transferrin	low	1	0
vecuronium bromide	low	1	0
fomesafen	low	1	0
mifepristone	low	1	0
fibrinogen	low	1	0
homocysteine	low	1	0
3,3',5-triiodothyronamine	low	1	0
aminopterin	low	1	0
angiotensin ii	low	1	0
cortisone	low	2	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
fibrin	low	1	0
bradykinin	low	1	0
oxytocin	low	13	0
ouabain	low	1	0
pancuronium	low	1	0
ergonovine	low	1	0
fumaric acid	low	1	0
cocaine	low	1	0
diethylstilbestrol	low	1	0
propylthiouracil	low	1	0
sulindac	low	2	0
digoxin	low	3	0
lithium	low	3	0
quinine	low	1	0
17-ketosteroids	low	2	0
bilirubin	low	9	0
dinoprostone	low	4	0
dinoprost	low	2	0
cholecalciferol	medium	1	1
isotretinoin	low	1	0
misoprostol	low	2	0
phenylephrine hydrochloride	low	1	0
morphine	low	32	0
cloprostenol	low	1	0
sulprostone	low	1	0
fumarates	low	1	0
urobilin	low	1	0
pregnanediol	low	1	0
sc 236	low	1	0
losartan potassium	low	2	0
alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc	low	1	0
indocyanine green	low	1	0
pituitrin	low	3	0
jaw	low	1	0
atrial natriuretic factor	low	4	0
neuropeptide y	low	1	0
endothelin-1	low	1	0
phosphatidylcholines	low	9	0
menotropins	low	1	0
sodium ethylxanthate	low	1	0
glycolipids	low	7	0
natriuretic peptide, brain	low	1	0
angiotensin i	low	2	0
lactoferrin	low	1	0
acyclovir	low	1	0
cyclic gmp	low	1	0
folic acid	low	2	0
valacyclovir	low	1	0
leptin	low	1	0

Protein Targets (1,017)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	18	0	0	18
USP1 protein, partial	18	0	0	18
TDP1 protein	35	0	0	35
vitamin D3 receptor isoform VDRA	17	0	0	17
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	4	0	0	4
serine/threonine-protein kinase PLK1	8	0	0	8
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	11	0	0	11
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	37	0	0	37
DNA polymerase kappa isoform 1	11	0	0	11
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	4
Fatty acid-binding protein, intestinal	0	3	1	4
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	7	0	0	7
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	4	0	4
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
5-hydroxytryptamine receptor 2C	0	4	1	6
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 1A	0	10	2	12
5-hydroxytryptamine receptor 1B	0	6	1	7
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	4	1	5
5-hydroxytryptamine receptor 6	0	1	1	2
Sodium-dependent serotonin transporter	0	6	1	7
Sodium-dependent serotonin transporter	0	4	0	5
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
RAR-related orphan receptor gamma	26	0	0	26
ATAD5 protein, partial	14	0	0	14
GLS protein	14	0	0	14
Microtubule-associated protein tau	17	0	0	17
Smad3	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	25	0	0	25
thyroid stimulating hormone receptor	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	22	0	0	22
progesterone receptor	23	0	0	23
EWS/FLI fusion protein	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	27	0	0	27
estrogen-related nuclear receptor alpha	37	0	0	37
estrogen nuclear receptor alpha	52	0	0	52
peroxisome proliferator activated receptor gamma	30	0	0	30
aryl hydrocarbon receptor	16	0	0	16
chromobox protein homolog 1	20	0	0	20
thyroid hormone receptor beta isoform 2	25	0	0	25
peripheral myelin protein 22	17	0	0	17
cytochrome P450 3A4 isoform 1	13	0	0	13
Gamma-aminobutyric acid receptor subunit pi	13	3	3	19
ATP-binding cassette sub-family C member 3	0	22	0	22
Multidrug resistance-associated protein 4	0	22	0	25
Solute carrier family 22 member 6	0	10	0	12
Carbonic anhydrase 12	0	5	0	7
UDP-glucuronosyltransferase 1A9	0	0	0	2
Bile salt export pump	0	8	0	8
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Bile salt export pump	0	38	0	38
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	16	0	22
Carbonic anhydrase 2	0	18	1	25
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	1	1	3
Prostaglandin G/H synthase 1	0	10	0	11
Carbonic anhydrase 3	0	4	0	5
Cytochrome P450 3A4	0	7	3	10
Cytochrome P450 2D6	0	5	1	6
Cytochrome P450 2C9	0	15	1	16
Polyunsaturated fatty acid lipoxygenase ALOX15	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	13	3	3	19
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	13	3	3	19
Gamma-aminobutyric acid receptor subunit gamma-2	13	3	3	19
UDP-glucuronosyltransferase 1-6	0	2	0	3
Glutamate receptor 2	16	0	0	16
Gamma-aminobutyric acid receptor subunit alpha-5	13	3	3	19
Gamma-aminobutyric acid receptor subunit alpha-3	13	3	3	19
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	4
Carbonic anhydrase 4	0	9	0	11
Prostaglandin G/H synthase 1	0	10	0	10
Carbonic anhydrase 6	0	5	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	13	3	3	19
Gamma-aminobutyric acid receptor subunit alpha-2	13	3	3	19
Gamma-aminobutyric acid receptor subunit alpha-4	13	3	3	19
Gamma-aminobutyric acid receptor subunit gamma-3	13	3	3	19
Gamma-aminobutyric acid receptor subunit alpha-6	13	3	3	19
Carbonic anhydrase 5A, mitochondrial	0	5	0	8
Prostaglandin G/H synthase 2	0	8	1	10
Carbonic anhydrase 7	0	4	0	6
Nuclear receptor ROR-gamma	9	2	2	13
Cytochrome P450 2J2	0	9	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	13	3	3	19
Gamma-aminobutyric acid receptor subunit beta-3	13	3	3	19
Gamma-aminobutyric acid receptor subunit beta-2	13	3	3	19
Carbonic anhydrase 9	0	7	1	10
GABA theta subunit	13	3	3	19
Canalicular multispecific organic anion transporter 1	0	19	0	20
Carbonic anhydrase 15	0	6	0	7
Carbonic anhydrase 13	0	4	0	6
Gamma-aminobutyric acid receptor subunit epsilon	13	3	3	19
Carbonic anhydrase 14	0	4	0	6
Carbonic anhydrase 5B, mitochondrial	0	4	0	7
toxin B	0	0	0	1
glucocorticoid receptor [Homo sapiens]	35	0	0	35
lamin isoform A-delta10	35	0	0	35
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Chain A, Ferritin light chain	9	0	0	9
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	12	0	0	12
arylsulfatase A	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	33	0	0	33
activating transcription factor 6	17	0	0	17
Histone H2A.x	10	0	0	10
Bloom syndrome protein isoform 1	12	0	0	12
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Solute carrier family 22 member 1	0	6	0	9
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	6	0	11
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	6	0	11
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	18	0	0	18
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	1	7
Proton-coupled amino acid transporter 1	0	4	0	4
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
AR protein	44	0	0	44
thyroid hormone receptor beta isoform a	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
Sex hormone-binding globulin	0	0	5	5
Corticosteroid-binding globulin	0	5	0	5
Mineralocorticoid receptor	1	3	3	8
Androgen receptor	0	6	0	6
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	3	0	5
acetylcholinesterase	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	27	0	0	27
cytochrome P450 2D6	15	0	0	15
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
SMAD family member 2	15	0	0	15
SMAD family member 3	15	0	0	15
farnesoid X nuclear receptor	24	0	0	24
pregnane X nuclear receptor	30	0	0	30
peroxisome proliferator-activated receptor delta	23	0	0	23
vitamin D (1,25- dihydroxyvitamin D3) receptor	24	0	0	24
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
heat shock protein beta-1	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 1	37	0	0	37
Dihydrofolate reductase	0	6	0	6
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	2
Cellular tumor antigen p53	24	0	0	24
Dihydrofolate reductase	0	3	2	6
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	4	0	6
Folylpolyglutamate synthase, mitochondrial	0	0	0	3
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Chain A, Cruzipain	10	0	0	10
Beta-lactamase	0	0	0	1
GLI family zinc finger 3	31	0	0	31
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
DNA polymerase beta	3	0	0	3
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	6	0	7
Solute carrier family 15 member 1	0	3	0	3
Spike glycoprotein	12	0	0	12
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	4	0	4
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	4	0	4
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	3	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	4	0	4
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
ATP-dependent phosphofructokinase	10	0	0	10
interleukin 8	7	0	0	7
estrogen receptor 2 (ER beta)	18	0	0	18
regulator of G-protein signaling 4	15	0	0	15
nonstructural protein 1	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	20	0	0	20
Caspase-7	4	0	0	4
peripheral myelin protein 22 isoform 1	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
caspase-3	4	0	0	4
mitogen-activated protein kinase 1	7	0	0	7
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	14	0	0	14
survival motor neuron protein isoform d	15	0	0	15
muscleblind-like protein 1 isoform 1	8	0	0	8
neuropeptide S receptor isoform A	8	0	0	8
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	2	0	2
Aromatase	0	2	0	4
Gastrin/cholecystokinin type B receptor	0	1	0	2
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Alpha-synuclein	3	3	0	6
TAR DNA-binding protein 43	6	0	0	6
glucocerebrosidase	4	0	0	4
histone acetyltransferase KAT2A isoform 1	10	0	0	10
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	3	0	3
cytochrome P450 2C19 precursor	6	0	0	6
lethal factor (plasmid)	7	0	0	7
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	1	6
Glutamate receptor ionotropic, NMDA 2B	0	4	1	6
Glutamate receptor ionotropic, NMDA 2C	0	4	1	6
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	4	1	6
Glutamate receptor ionotropic, NMDA 3B	0	4	1	6
Glutamate receptor ionotropic, NMDA 3A	0	4	1	6
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
pregnane X receptor	6	0	0	6
IDH1	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	1	12	2	17
Glycine receptor subunit alpha-1	0	12	0	12
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
ORF73	0	0	2	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	5	0	7
Solute carrier organic anion transporter family member 1B1	0	5	0	8
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	1	4	5
Carbonic anhydrase	0	4	0	5
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
Interferon beta	22	0	0	22
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	2	0	3
NFKB1 protein, partial	4	0	0	4
transcriptional regulator ERG isoform 3	3	0	0	3
muscarinic acetylcholine receptor M1	7	0	0	7
Luciferase	14	0	0	14
15-lipoxygenase, partial	2	0	0	2
60 kDa chaperonin	0	3	0	3
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	3	3
Vitamin D3 receptor	0	0	1	1
Prostaglandin G/H synthase 1	0	4	0	5
Prostaglandin G/H synthase 2	0	4	0	5
Thromboxane A2 receptor	0	2	2	4
Prostaglandin E2 receptor EP1 subtype	0	4	3	7
Prostaglandin E2 receptor EP4 subtype	0	4	1	5
Prostaglandin F2-alpha receptor	0	4	3	7
Prostaglandin E2 receptor EP3 subtype	0	4	3	7
Prostaglandin E2 receptor EP2 subtype	0	4	1	5
Prostacyclin receptor	0	4	1	5
Prostaglandin D2 receptor	0	2	0	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	3
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	3	8
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	2	7
D	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	6	0	6
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Leukotriene B4 receptor 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Sodium-dependent dopamine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	7	1	8
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Leukotriene B4 receptor 2	0	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Transporter	0	2	0	2
endonuclease IV	2	0	0	2
dopamine D1 receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
M-phase phosphoprotein 8	7	0	0	7
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
Multidrug and toxin extrusion protein 1	0	5	0	5
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
thyroid stimulating hormone receptor	13	0	0	13
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
G-protein coupled bile acid receptor 1	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
glp-1 receptor, partial	9	0	0	9
G	16	0	0	16
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
Fatty acid-binding protein, liver	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	8	5	14
Albumin	0	0	3	3
ATP-dependent translocase ABCB1	0	9	0	12
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Neuronal acetylcholine receptor subunit beta-2	1	2	0	3
Translocator protein	0	1	2	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Inositol hexakisphosphate kinase 1	16	0	0	16
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
cytochrome P450 2C9, partial	16	0	0	16
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
67.9K protein	8	0	0	8
cellular tumor antigen p53 isoform a	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
5-hydroxytryptamine receptor 4	0	10	0	10
Nuclear receptor subfamily 1 group I member 2	0	1	2	3
Estrogen receptor	1	6	2	9
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Integrin beta-3	5	1	0	6
Tyrosine-protein kinase Fyn	0	2	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Integrin alpha-IIb	5	1	0	6
Beta-1 adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	6	1	7
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Adenosine receptor A3	0	8	0	8
Muscarinic acetylcholine receptor M1	0	2	0	3
D(2) dopamine receptor	0	7	0	7
Alpha-1B adrenergic receptor	0	8	0	8
Alpha-2B adrenergic receptor	0	10	0	10
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	3
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	6	0	6
Acetylcholinesterase	0	4	0	4
Thromboxane-A synthase	0	3	0	3
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	10	0	10
Adenosine receptor A2a	0	3	0	3
Adenosine receptor A1	0	6	0	6
Mu-type opioid receptor	0	8	2	11
D(3) dopamine receptor	0	7	0	7
Vasopressin V1a receptor	0	4	1	5
Delta-type opioid receptor	0	6	1	8
Kappa-type opioid receptor	0	8	1	10
5-hydroxytryptamine receptor 2B	0	12	1	13
Alpha-1A adrenergic receptor	0	8	0	8
Histamine H2 receptor	7	0	0	7
5-hydroxytryptamine receptor 6	0	6	0	6
Estrogen-related receptor gamma	0	0	1	1
Aldehyde oxidase	0	1	0	1
UDP-glucose 4-epimerase	0	2	0	2
Estrogen receptor beta	1	4	2	7
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
Cysteinyl leukotriene receptor 1	0	2	0	2
PAX8	0	0	0	1
PPM1D protein	2	0	0	2
STAT3, partial	0	2	0	2
thioredoxin glutathione reductase	6	0	0	6
alpha-galactosidase	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
tumor necrosis factor	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	2	0	2
Solute carrier organic anion transporter family member 1A4	0	4	0	8
Sodium/potassium-transporting ATPase subunit alpha-1	0	5	0	6
Sodium/potassium-transporting ATPase subunit beta-1	0	5	0	6
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Replicase polyprotein 1ab	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	3	0	4
Sodium/potassium-transporting ATPase subunit beta-2	0	3	0	4
ATP-dependent translocase ABCB1	0	3	1	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	5	0	6
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	3	0	4
Sodium/potassium-transporting ATPase subunit gamma	0	3	0	4
Sodium/potassium-transporting ATPase subunit alpha-4	0	3	0	4
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	4
Solute carrier organic anion transporter family member 4C1	0	0	0	2
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier family 22 member 2	0	3	0	6
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	2	0	4
Solute carrier family 22 member 7	0	1	0	5
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier family 22 member 7	0	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	4
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	6
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-3 adrenergic receptor	0	0	1	1
Endothelin-1 receptor	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	5
Lanosterol 14-alpha demethylase	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
Chain A, GLUTATHIONE TRANSFERASE A1-1	0	1	0	1
Chain A, Glutathione S-transferase P1-1	0	1	0	1
Chain A, Glutathione S-transferase P1-1	0	1	0	1
Chain B, Glutathione S-transferase P1-1	0	1	0	1
Nrf2	1	0	0	1
WRN	1	0	0	1
caspase 7, apoptosis-related cysteine protease	3	0	0	3
isocitrate dehydrogenase 1, partial	1	0	0	1
caspase-3	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
cytochrome P450 2C9 precursor	5	0	0	5
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
histone deacetylase 9 isoform 3	1	0	0	1
huntingtin isoform 2	3	0	0	3
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
Hematopoietic prostaglandin D synthase	0	1	0	1
Glutathione S-transferase A1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Replicase polyprotein 1a	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 6	0	1	0	1
Glutathione S-transferase omega-1	0	2	0	2
14 kDa phosphohistidine phosphatase	0	2	0	2
large T antigen	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	4	0	5
Delta-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	5	2	10
Kappa-type opioid receptor	0	3	1	5
Histamine H1 receptor	0	1	0	1
Kappa-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
GALC protein	3	0	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	5	0	5
Multidrug resistance associated protein	0	0	0	1
Lysine-specific demethylase 4E	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Egl nine homolog 1	0	1	1	2
Methyl-accepting chemotaxis protein NahY	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	4
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
Carbonic anhydrase	0	1	0	1
Hsf1 protein	0	0	1	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Epidermal growth factor receptor	0	4	0	4
Albumin	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	5
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	2	1	4
Caspase-1	0	2	0	3
Adenosine receptor A2a	0	3	1	5
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	3
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	2	0	2
Caspase-4	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	6	0	6
Fatty-acid amide hydrolase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	4
Prostaglandin G/H synthase 1	0	2	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	4	0	0	4
cytochrome P450 2D6 isoform 1	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Procathepsin L	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	1	3	2	6
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	3	0	3
Nitric oxide synthase, inducible	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	7	7
Sodium- and chloride-dependent betaine transporter	0	2	0	2
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Lactoylglutathione lyase	0	3	0	3
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
Cellular retinoic acid-binding protein 1	0	0	2	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chymotrypsinogen A	0	1	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Fumarate hydratase	4	0	0	4
polyprotein	4	0	0	4
DNA polymerase III, partial	1	0	0	1
D(1A) dopamine receptor	5	0	0	5
tumor susceptibility gene 101 protein	1	0	0	1
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Glucocorticoid receptor	0	1	0	1
hypothetical protein, conserved	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Progesterone receptor	0	2	1	5
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	1	1	3
Glucocorticoid receptor	0	1	0	1
Coagulation factor VII	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Thyroid hormone receptor alpha	0	3	3	6
Thyroid hormone receptor beta	0	3	3	6
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tissue factor	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Progesterone receptor	0	0	1	1
Glucocorticoid receptor	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	2	0	2
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	2
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
ubiquitin-like modifier-activating enzyme 1	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ubiquitin-conjugating enzyme E2 variant 1 isoform a	0	1	0	1
Prothrombin	0	1	1	2
Complement C1r subcomponent	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	2	0	2
Coagulation factor XII	0	1	0	1
Cationic trypsin	0	1	0	1
Interstitial collagenase	0	1	0	1
Serine protease hepsin	0	2	0	2
Cathepsin D	0	1	0	1
Trypsin-1	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Complement C1s subcomponent	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Hepatocyte growth factor activator	0	2	1	3
Suppressor of tumorigenicity 14 protein	0	1	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Thrombopoietin	1	0	0	1
beta-2 adrenergic receptor	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium channel subfamily K member 2	0	1	2	3
Glutathione reductase, mitochondrial	0	2	0	2
Muscarinic acetylcholine receptor M2	0	0	0	1
Muscarinic acetylcholine receptor M4	0	0	0	1
Muscarinic acetylcholine receptor M5	0	0	0	1
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
ClpP	1	0	0	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	2	0	2
Bombesin receptor subtype-3	0	0	1	1
Cytochrome P450 2C19	0	1	1	3
UDP-glucuronosyltransferase 2B10	0	2	0	2
Fatty acid synthase	0	2	0	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
WD repeat-containing protein 5	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
Kruppel-like factor 5	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Peptidylglycine alpha-amidating monooxygenase	0	0	0	1
Solute carrier family 22 member 1	0	3	0	5
Solute carrier family 22 member 2	0	3	0	3
Cytochrome P450 2D26	0	2	0	2
Cytochrome P450 2D3	0	2	0	2
Cytochrome P450 2D4	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Beta-2 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
streptokinase A precursor	0	0	1	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Estrogen receptor	0	0	1	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Estrogen receptor beta	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Acetylcholinesterase	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Aurora kinase A	0	1	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
Complement C5	0	0	1	1
Retinoic acid receptor RXR-alpha	0	3	4	7
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Proliferating cell nuclear antigen	0	2	0	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (308)

Protein Targets (1,017)

Hydramnios

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (308)

Drugs Studied (161)

Protein Targets (1,017)