Page last updated: 2024-12-08

3,3',5-triiodothyronamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,3',5-triiodothyronamine: potential metabolite of T3; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID165262
CHEMBL ID201885
SCHEMBL ID12921186
MeSH IDM0120345

Synonyms (17)

Synonym
4-[4-(2-aminoethyl)-2,6-diiodophenoxy]-2-iodophenol
4731-88-8
3,3',5-triiodothyronamine
CHEMBL201885 ,
bdbm50181816
3,3'',5-triiodothyronamine
phenol, 4-(4-(2-aminoethyl)-2,6-diiodophenoxy)-2-iodo-
unii-jfu2ll83mx
triiodothyronamine
jfu2ll83mx ,
SCHEMBL12921186
DTXSID40197100
phenol, 4-[4-(2-aminoethyl)-2,6-diiodophenoxy]-2-iodo-
Q4634051
thyronamine, 3,3',5-triiodo-
4-(4-(2-aminoethyl)-2,6-diiodophenoxy)-2-iodophenol
3,5,3'-triiodothyronamine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Trace amine-associated receptor 1Mus musculus (house mouse)EC50 (µMol)1.00000.00200.69705.4000AID259978
Trace amine-associated receptor 1Rattus norvegicus (Norway rat)EC50 (µMol)0.08700.01390.42632.0440AID259977
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID259977Activity at rat TAAR1 by measuring cAMP accumulation in HEK293 cells2006Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3
Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.
AID259978Activity at mouse TAAR1 by measuring cAMP accumulation in HEK293 cells2006Journal of medicinal chemistry, Feb-09, Volume: 49, Issue:3
Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (15.38)18.7374
1990's0 (0.00)18.2507
2000's13 (50.00)29.6817
2010's7 (26.92)24.3611
2020's2 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.85 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (3.85%)5.53%
Reviews2 (7.69%)6.00%
Case Studies1 (3.85%)4.05%
Observational0 (0.00%)0.25%
Other22 (84.62%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]