Page last updated: 2024-11-04

triclofos

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

triclofos: derivative 7 metabolic precursor of trichloroethanol; RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5563
CHEMBL ID1201317
CHEBI ID9695
SCHEMBL ID125854
MeSH IDM0045368

Synonyms (47)

Synonym
2,2,2-trichloroethyl dihydrogen phosphate
inchi=1/c2h4cl3o4p/c3-2(4,5)1-9-10(6,7)8/h1h2,(h2,6,7,8
2,2,2-trichloroethanol dihydrogen phosphate
2,2,2-trichloroethyl phosphate
trichloroethanol-1-phosphate
triclofosa [inn-spanish]
trichloryl
triclofosum [inn-latin]
trichlophos
einecs 206-185-6
phosphoric acid, 2,2,2-trichloroethyl ester
triclofoso [dcit]
hsdb 3276
2,2,2-trichloroethanol, dihydrogen phosphate
ethanol, 2,2,2-trichloro-, dihydrogen phosphate
brn 1841552
triclofos [inn:ban]
trichloroethyl dihydrogen phosphate
trichloroethanol 1-phosphate
306-52-5
triclofos
C07165
D08634
neguvon [veterinary] (tn)
triclofos (inn)
triclofoso
triclofosa
unii-j712eo9048
j712eo9048 ,
CHEMBL1201317
triclofosum
triclofos [inn]
triclofos [mi]
tri-beta-chloroethylphosphate
triclofos [hsdb]
triclofos [who-dd]
SCHEMBL125854
CHEBI:9695 ,
DTXSID9023700
(2,2,2-trichloroethoxy)phosphonic acid
DB06753
Q15305564
SY299205
mfcd00242992
CS-0613731
HY-148149
EN300-7653367

Research Excerpts

Effects

ExcerptReferenceRelevance
"Triclofos sodium (TFS) has been used for many years in children as a sedative for painless medical procedures. "( Triclofos Sodium for Pediatric Sedation in Non-Painful Neurodiagnostic Studies.
Daka, A; Kadmon, G; Kaplan, E; Kraus, D; Milkh, R; Nahum, E; Weissbach, A, 2019
)
3.4

Toxicity

We studied the efficacy and adverse effects of rectal thiamylal in combination with oral triclofos in sedation for pediatric magnetic resonance imaging. Administration of oral Triclfos in a dose of 80 mg/kg body weight was safe and effective in children less than 5 years of age.

ExcerptReferenceRelevance
"We studied the efficacy and adverse effects of rectal thiamylal in combination with oral triclofos in sedation for pediatric magnetic resonance imaging."( Efficacy and adverse effects of rectal thiamylal with oral triclofos for children undergoing magnetic resonance imaging.
Itomi, K; Iwata, S; Kato, T; Kuno, K; Okumura, A, 2006
)
0.8
"Administration of oral Triclofos in a dose of 80 mg/kg body weight was safe and effective in children less than 5 years of age undergoing ocular examination."( Safety and efficacy of oral Triclofos in the ophthalmic evaluation of children with pediatric glaucoma: An observational study.
Bloria, SD; Chauhan, R; Joshi, G; Kaushik, S; Luthra, A; Meena, S; Sarna, R; Sethi, S, 2021
)
1.23
" However, there are no reports of an association of adverse events and examination success rates with patient medical backgrounds using a combination of these sedatives."( Patient background related to success and adverse event in pediatric sedated MRI.
Akiyama, L; Fujii, K; Hiramoto, R; Kawasaki, Y; Konda, Y; Mihira, H; Ozawa, Y; Shiko, Y, 2022
)
0.72
" Outcomes were sedation success and adverse events, including oxygen desaturation."( Patient background related to success and adverse event in pediatric sedated MRI.
Akiyama, L; Fujii, K; Hiramoto, R; Kawasaki, Y; Konda, Y; Mihira, H; Ozawa, Y; Shiko, Y, 2022
)
0.72
" The only adverse event was oxygen desaturation (11."( Patient background related to success and adverse event in pediatric sedated MRI.
Akiyama, L; Fujii, K; Hiramoto, R; Kawasaki, Y; Konda, Y; Mihira, H; Ozawa, Y; Shiko, Y, 2022
)
0.72

Dosage Studied

ExcerptRelevanceReference
" This new method can be applied for the pharmacokinetic analysis of TCS and its metabolites and the determination of the optimal TCS dosage in children."( Simple method to detect triclofos and its metabolites in plasma of children by combined use of liquid chromatography tandem-mass spectrometry and gas chromatography-mass spectrometry.
Hashimoto, S; Inoue, M; Ito, Y; Kamijima, M; Nakahira, Y; Nakajima, T; Sato, H, 2019
)
0.82
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
monoalkyl phosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (42)

TimeframeStudies, This Drug (%)All Drugs %
pre-199016 (38.10)18.7374
1990's7 (16.67)18.2507
2000's7 (16.67)29.6817
2010's6 (14.29)24.3611
2020's6 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 65.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index65.92 (24.57)
Research Supply Index4.04 (2.92)
Research Growth Index4.72 (4.65)
Search Engine Demand Index108.03 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (65.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials11 (24.44%)5.53%
Reviews2 (4.44%)6.00%
Case Studies4 (8.89%)4.05%
Observational3 (6.67%)0.25%
Other25 (55.56%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]