valproic acid has been researched along with Neonatal Abstinence Syndrome in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Neonatal Abstinence Syndrome: Fetal and neonatal addiction and withdrawal as a result of the mother's dependence on drugs during pregnancy. Withdrawal or abstinence symptoms develop shortly after birth. Symptoms exhibited are loud, high-pitched crying, sweating, yawning and gastrointestinal disturbances.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty epileptic women were treated with valproate only during pregnancy and two were treated with valproate and carbamazepine." | 3.70 | Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate. ( Ebbesen, F; Holsteen, V; Hoseth, E; Joergensen, A; Kaad, PH; Moeller, M; Rix, M, 2000) |
| " However, women must balance the benefit of treatment against all possible adverse effects." | 1.62 | Active Surveillance of the Safety of Medications Used During Pregnancy. ( Bateman, BT; Hernández-Díaz, S; Huybrechts, KF; Kulldorff, M; Mogun, H; Wang, SV; Zhu, Y, 2021) |
| " The frequency of withdrawal symptoms was significantly related to the dose of valproate given to the mothers in the third trimester, and there was a tendency for both the frequency of the minor abnormalities and the major malformations to be related to the valproate dosage in the first trimester." | 1.29 | Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero. ( Ebbesen, F; Thisted, E, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Huybrechts, KF | 1 |
| Kulldorff, M | 1 |
| Hernández-Díaz, S | 1 |
| Bateman, BT | 1 |
| Zhu, Y | 1 |
| Mogun, H | 1 |
| Wang, SV | 1 |
| Thisted, E | 1 |
| Ebbesen, F | 2 |
| Joergensen, A | 1 |
| Hoseth, E | 1 |
| Kaad, PH | 1 |
| Moeller, M | 1 |
| Holsteen, V | 1 |
| Rix, M | 1 |
3 other studies available for valproic acid and Neonatal Abstinence Syndrome
| Article | Year |
|---|---|
Active Surveillance of the Safety of Medications Used During Pregnancy.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Cohort Studies; Data Mining; Databases, Factual; Fe | 2021 |
Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero.
Topics: Drug Administration Schedule; Epilepsy; Female; Heart Defects, Congenital; Humans; Infant, Newborn; | 1993 |
Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Hypoglycemia; I | 2000 |