Page last updated: 2024-12-06

zipeprol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

zipeprol: RN given refers to parent cpd; synonyms 3024 CERM & respilene refers to di-HCl; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	36910
CHEMBL ID	2105497
CHEBI ID	135602
SCHEMBL ID	364352
MeSH ID	M0061020

Synonyms (32)

Synonym
1-piperazineethanol, 4-(2-methoxy-2-phenylethyl)-.alpha.-(methoxyphenylmethyl)-
zipeprol
D07390
34758-83-3
zo-tab (tn)
zipeprol (inn)
zipeprolum [inn-latin]
alpha-(alpha-methoxybenzyl)-4-(beta-methoxyphenethyl)-1-piperazineethanol
einecs 252-191-7
4-(2-methoxy-2-phenylethyl)-alpha-(methoxyphenylmethyl)-1-piperazineethanol
zipeprol [inn:dcf]
CHEBI:135602
unii-g5muv8139h
zipeprolum
g5muv8139h ,
CHEMBL2105497
zo-tab
zipeprol [mi]
(1-methoxy-3-[4-(2-methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-2-ol
zipeprol [inn]
dea no. 9873
zipeprol [who-dd]
SCHEMBL364352
.alpha.-(.alpha.-methoxybenzyl)-4-(.beta.-methoxyphenethyl)-1-piperazineethanol
4-(2-methoxy-2-phenylethyl)-.alpha.-(methoxyphenylmethyl)-1-piperazineethanol
1-(2-methoxy-2-phenylethyl)-4-(2-hydroxy-3-methoxy-3-phenylpropyl)piperazine
VSTNNAYSCJQCQI-UHFFFAOYSA-N
1-methoxy-3-[4-(2-methoxy-2-phenylethyl)-1-piperazinyl]-1-phenyl-2-propanol #
4-acetyl-1,1-dimethylpiperaziniumiodide
DTXSID00865732
Q4024559
DB13564

Research Excerpts

Overview

Zipeprol hydrochloride is a synthetic antitussive agent that has shown little evidence of addictive potential in animal studies. It is a non-opioid cough suppressor agent.

Excerpt	Reference	Relevance
"Zipeprol is a non opioid antitussive agent derived from piperazine. "	( [Addiction to zipeprol. Report of 2 cases]. Salvo, J; Silva, H, 1993)	2.09
"Zipeprol hydrochloride is a synthetic antitussive agent that has shown little evidence of addictive potential in animal studies. "	( Habituation to zipeprol hydrochloride during pregnancy. Jesurun, CA; Levin, G; Slobodkin, D; Thompson, D, 1992)	2.08
"Zipeprol is a non-opioid cough suppressor agent recently abused in Italy. "	( Zipeprol is a newly abused antitussive with an opioid spectrum and hallucinogenic effects. Diodato, S; Janiri, L; Mannelli, P; Persico, AM; Tempesta, E, 1991)	3.17

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
benzyl ether	A compound of formula PhCH2OR (R =/= H).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (27)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (37.04)	18.7374
1990's	15 (55.56)	18.2507
2000's	2 (7.41)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	37.48 (24.57)
Research Supply Index	3.56 (2.92)
Research Growth Index	4.29 (4.65)
Search Engine Demand Index	53.49 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (37.48)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	11 (32.35%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (67.65%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ammonium hydroxide azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.	1.96	1	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant
carisoprodol Carisoprodol: A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202). carisoprodol : A carbamate ester that is the mono-N-isopropyl derivative of meprobamate (which is a significant metabolite). Carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. It is used as a muscle relaxant in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.	2.02	1	carbamate ester	muscle relaxant
dipropizine [no description available]	1.97	1	piperazines
eprazinone eprazinone : A member of the class of piperazines in which the two amino hydrogens of piperazine are replaced by 2-benzoylpropyl and 2-ethoxy-2-phenylethyl groups.	6.96	1	aromatic ketone; ether; N-alkylpiperazine	mucolytic
flunitrazepam Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.. flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.	7	1	1,4-benzodiazepinone; C-nitro compound; monofluorobenzenes	anxiolytic drug; GABAA receptor agonist; sedative
trihexyphenidyl Trihexyphenidyl: One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.	7	1	amine
diphenhydramine hydrochloride Antitussive Agents: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.. diphenhydramine hydrochloride : The hydrochloride salt of diphenhydramine.	5.28	21	hydrochloride; organoammonium salt	anti-allergic agent; antiemetic; antiparkinson drug; antipruritic drug; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; sedative
methamphetamine Methamphetamine: A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.. methamphetamine : A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.	1.99	1	amphetamines; secondary amine	central nervous system stimulant; environmental contaminant; neurotoxin; psychotropic drug; xenobiotic
butamirate butamirate: RN, N1 & SY refer to citrate salt; structure	7.89	1	alkylbenzene
codeine [no description available]	1.97	1	morphinane alkaloid; organic heteropentacyclic compound	antitussive; drug allergen; environmental contaminant; opioid analgesic; opioid receptor agonist; prodrug; xenobiotic
nalbuphine Nalbuphine: A narcotic used as a pain medication. It appears to be an agonist at KAPPA RECEPTORS and an antagonist or partial agonist at MU RECEPTORS.	2.02	1	organic heteropentacyclic compound	mu-opioid receptor antagonist; opioid analgesic
dextromethorphan Dextromethorphan: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.. dextromethorphan : A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.	2.69	3	6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene	antitussive; environmental contaminant; neurotoxin; NMDA receptor antagonist; oneirogen; prodrug; xenobiotic

Condition	Indicated	Relationship Strength	Studies
Chemical Dependence [description not available]	0	3.93	13
Substance-Related Disorders Disorders related to substance use or abuse.	0	3.93	13
Drug Overdose Accidental or deliberate use of a medication or street drug in excess of normal dosage.	0	3.09	5
Absence Seizure [description not available]	0	2.88	4
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	0	2.88	4
Brain Swelling [description not available]	0	1.96	1
Brain Edema Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)	0	1.96	1
Drug Withdrawal Symptoms [description not available]	0	2.67	3
Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.	0	2.67	3
Nervous System Disorders [description not available]	0	1.98	1
Psychoses, Drug [description not available]	0	1.98	1
Nervous System Diseases Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.	0	1.98	1
Antisocial Behavior Behavior that sharply deviates from social norms and violates rights of others	0	1.98	1
Addiction, Opioid [description not available]	0	2.39	2
Drug Abuse, Intravenous [description not available]	0	1.99	1
Opioid-Related Disorders Disorders related to or resulting from abuse or misuse of OPIOIDS.	0	2.39	2
Abstinence Syndrome, Neonatal [description not available]	0	1.98	1
Neonatal Abstinence Syndrome Fetal and neonatal addiction and withdrawal as a result of the mother's dependence on drugs during pregnancy. Withdrawal or abstinence symptoms develop shortly after birth. Symptoms exhibited are loud, high-pitched crying, sweating, yawning and gastrointestinal disturbances.	0	1.98	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	0	6.98	1
Hallucination of Body Sensation [description not available]	0	2.38	2
Hallucinations Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.	0	2.38	2
Cough A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.	1	3.97	1

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