trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride has been researched along with Alobar Holoprosencephaly in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chevy, F; Citadelle, D; Cormier, V; Kolf, M; Le Merrer, M; Llirbat, B; Mulliez, N; Roux, C; Taillemite, JL; Wolf, C | 1 |
| Batta, AK; Salen, G | 1 |
| Beachy, PA; Cooper, MK; Porter, JA; Young, KE | 1 |
| Incardona, JP; Roelink, H | 1 |
| Bourguignon, L; Gaoua, W; Gofflot, F; Picard, JJ; Roux, C | 1 |
| Biade, S; Citadelle, D; Dupuis, R; Maziere, JC; Meier, M; Quiec, D; Repetto, M; Roux, C | 1 |
3 review(s) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Alobar Holoprosencephaly
| Article | Year |
|---|---|
[Cholesterol and development].
Topics: Animals; Anticholesteremic Agents; Cholesterol; Embryonic and Fetal Development; Genes; Holoprosencephaly; In Vitro Techniques; Mice; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1997 |
Abnormal cholesterol biosynthesis produced by AY 9944 in the rat leads to skeletal deformities similar to the Smith-Lemli-Opitz syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Bone and Bones; Bone Development; Cholesterol; Enzyme Inhibitors; Female; Holoprosencephaly; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1998 |
The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cholesterol; Hedgehog Proteins; Holoprosencephaly; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Membrane Proteins; Models, Biological; Mutation; Niemann-Pick C1 Protein; Patched Receptors; Proteins; Receptors, Cell Surface; Signal Transduction; Teratogens; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators; Veratrum Alkaloids | 2000 |
3 other study(ies) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Alobar Holoprosencephaly
| Article | Year |
|---|---|
Teratogen-mediated inhibition of target tissue response to Shh signaling.
Topics: Abnormalities, Drug-Induced; Animals; Cell Membrane; Central Nervous System; Chick Embryo; Cholesterol; Culture Techniques; DNA-Binding Proteins; Endoplasmic Reticulum; Hedgehog Proteins; Hepatocyte Nuclear Factor 3-beta; Holoprosencephaly; Homeodomain Proteins; LIM-Homeodomain Proteins; Membrane Proteins; Muscle Proteins; Nerve Tissue Proteins; Nuclear Proteins; Patched Receptors; PAX7 Transcription Factor; Proteins; Receptors, Cell Surface; Signal Transduction; Teratogens; Tomatine; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators; Transcription Factors; Triparanol; Veratrum Alkaloids | 1998 |
Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Congenital Abnormalities; Dehydrocholesterols; Embryonic and Fetal Development; Embryonic Induction; Female; Gene Expression Regulation, Developmental; Hedgehog Proteins; Holoprosencephaly; Humans; In Situ Hybridization; Pregnancy; Proteins; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators | 2001 |
Teratogenic effect of the cholesterol synthesis inhibitor AY 9944 on rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Dehydrocholesterols; Embryonic and Fetal Development; Fetal Death; Holoprosencephaly; Morphogenesis; Organ Culture Techniques; Pituitary Gland; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1990 |