Hepatic Porphyria

Synonym
Porphyria, Hepatic
Hepatic Porphyria

Excerpt	Reference
"Hepatic porphyria is a rare metabolic syndrome caused by abnormal enzyme activity in heme biosynthesis."	( Armas, R; Chaná, P; Krause, P; Parraguez, A; Soto, J; Wolff, C, 1992)
"Patients with acute hepatic porphyria are denied essential operations because of concern that general anaesthesia and surgery will precipitate a life threatening porphyric crisis."	( Dover, SB; McColl, KE; Moore, MR; Plenderleith, L, 1994)
"Hepatic porphyrias are characterized by neurological symptoms manifested by abdominal pain, neuropathies and mental aberrations."	( Corbitt, W; Huschart, T; Lazovic, G; Long, P; Medenica, R; Mukerjee, S; Powell, D, 1997)
"The acute hepatic porphyrias are rare pharmacogenetic diseases inherited as autosomal dominant conditions of low penetrance."	( Gorchein, A, 1997)
"Acute hepatic porphyrias are risk factors for hepatocellular carcinoma."	( Andant, C; Bogard, C; Deybach, JC; Faivre, J; Nordmann, Y; Puy, H; Soulé, JC, 2000)
"Acute hepatic porphyrias are inherited metabolic disorders that may present with polyneuropathy, which if not diagnosed early can lead to quadriparesis, respiratory weakness, and death."	( Bonkovsky, HL; Caress, JB; Gandhi Mehta, RK; Rudnick, SR, 2021)
"The four acute hepatic porphyrias are relevant for anesthesiologists as precipitating factors are commonly found in the perioperative setting."	( Larmann, J; Lederer, D; Weigand, MA, 2022)
"Acute hepatic porphyrias are a group of rare, inherited metabolic disorders, characterized by acute potentially life-threatening attacks as well as chronic symptoms with a negative impact on quality of life."	( Bonkovsky, HL; Ma, CD; Majeed, CN; Rudnick, S; Xiao, T, 2022)

Excerpt	Reference
"Thus, hepatic porphyria is recognized with increasing frequency and can be treated successfully in most cases."	( Armas, R; Chaná, P; Krause, P; Parraguez, A; Soto, J; Wolff, C, 1992)
"The treatment of hepatic porphyrias by an RNAi-targeting hepatic ALAS1 is actually tested and may lead to improve the management of acute attacks."	( Gouya, L; Manceau, H; Puy, H, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	15 (9.38)	23.3326
1990's	59 (36.88)	12.5806
2000's	34 (21.25)	18.1394
2010's	21 (13.13)	28.8240
2020's	31 (19.38)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
aminolevulinic acid	medium	20	1
coproporphyrinogen iii	low	1	0
coumarin	low	1	0
cytosine	low	1	0
dihydroxyacetone	low	1	0
kynurenine	low	2	0
melatonin	low	1	0
niacin	low	1	0
porphobilinogen	medium	25	2
pyridoxine	low	1	0
thymine	low	1	0
urea	low	1	0
uroporphyrinogen iii	low	1	0
pk 11195	low	1	0
phenytoin	low	1	0
caffeine	medium	2	1
carbamazepine	low	3	0
chloroquine	low	2	0
chlorpromazine	low	1	0
cimetidine	low	1	0
dapsone	low	1	0
debrisoquin	low	1	0
deferoxamine	low	1	0
dimercaprol	low	1	0
valproic acid	low	2	0
fluorouracil	low	1	0
furosemide	low	1	0
gabapentin	low	2	0
hydroxychloroquine	low	1	0
hydroxyurea	low	1	0
lidocaine	low	1	0
meperidine	low	1	0
midazolam	medium	1	1
omeprazole	medium	1	1
phenobarbital	low	4	0
piracetam	low	1	0
primidone	low	1	0
propofol	low	6	0
protoporphyrin ix	low	2	0
sulfamethoxazole	low	1	0
tolbutamide	low	1	0
trimethoprim	low	2	0
xylometazoline	low	1	0
alanine	low	1	0
ethinyl estradiol	low	1	0
edetic acid	low	1	0
leucine	low	2	0
methionine	low	2	0
egtazic acid	low	1	0
histidine	low	1	0
valine	low	1	0
threonine	low	1	0
methandrostenolone	low	1	0
tryptophan	low	4	0
arginine	medium	13	1
phenyl ether	low	1	0
hexachlorobenzene	low	5	0
allylisopropylacetamide	low	1	0
apronalide	low	1	0
levulinic acid	low	1	0
dicarbethoxydihydrocollidine	low	4	0
d-alpha tocopherol	low	1	0
dithiothreitol	low	1	0
tiletamine hydrochloride	low	3	0
urobilinogen	low	1	0
phenyl acetate	low	2	0
transferrin	low	1	0
oxcarbazepine	low	2	0
zidovudine	low	1	0
acetylgalactosamine	medium	13	2
substance p	low	1	0
chlorodiphenyl (54% chlorine)	low	1	0
desogestrel	low	1	0
acifluorfen	low	1	0
fomesafen	low	2	0
mifepristone	low	1	0
adenosine	low	1	0
fluorodeoxyglucose f18	low	1	0
uroporphyrin iii	low	1	0
cp094	low	1	0
homocysteine	low	3	0
vitamin b 6	low	1	0
zinc coproporphyrin iii	low	3	0
n-methylprotoporphyrin ix	low	1	0
protoporphyrinogen	low	4	0
proline	low	1	0
griseofulvin	low	1	0
arachidonic acid	low	1	0
nadp	low	2	0
gestodene	low	1	0
harderoporphyrin	low	2	0
zinc protoporphyrin ix	low	1	0
bilirubin	low	2	0
phenylephrine hydrochloride	low	1	0
levetiracetam	low	1	0
lead	low	1	0
sulfur	low	1	0
nad	low	1	0
cholecystokinin	low	1	0
motilin	low	1	0
gastrins	low	1	0
neurotensin	low	1	0
vasoactive intestinal peptide	low	1	0
heme	medium	62	1
warfarin	low	1	0
gastrin-releasing peptide	low	1	0
norgestrel	low	1	0
deoxyguanosine	low	1	0
folic acid	low	1	0
allopurinol	low	1	0
8-hydroxy-2'-deoxyguanosine	low	1	0
2-(1-(ethoxyimino)propyl)-3-hydroxy-5-(2,4,6-trimethylphenyl)cyclohex-2-enone	low	1	0
heme arginate	medium	11	1
cholestyramine resin	low	1	0

Protein Targets (1,001)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
pregnane X receptor	8	0	0	8
GALC protein	5	0	0	5
TDP1 protein	26	0	0	26
GLI family zinc finger 3	28	0	0	28
AR protein	37	0	0	37
nuclear receptor subfamily 1, group I, member 3	19	0	0	19
progesterone receptor	17	0	0	17
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	30	0	0	30
retinoid X nuclear receptor alpha	20	0	0	20
estrogen-related nuclear receptor alpha	33	0	0	33
pregnane X nuclear receptor	25	0	0	25
estrogen nuclear receptor alpha	40	0	0	40
G	12	0	0	12
cytochrome P450 2D6	6	0	0	6
peroxisome proliferator-activated receptor delta	11	0	0	11
peroxisome proliferator activated receptor gamma	19	0	0	19
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
thyroid hormone receptor beta isoform 2	21	0	0	21
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Cellular tumor antigen p53	25	0	0	25
Acetyl-CoA carboxylase 1	0	1	0	1
Inositol hexakisphosphate kinase 1	12	0	0	12
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	9	0	0	9
cytochrome P450 2C9, partial	12	0	0	12
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	15	0	0	15
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
estrogen receptor 2 (ER beta)	13	0	0	13
glucocorticoid receptor [Homo sapiens]	24	0	0	24
farnesoid X nuclear receptor	17	0	0	17
vitamin D3 receptor isoform VDRA	11	0	0	11
chromobox protein homolog 1	18	0	0	18
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
geminin	34	0	0	34
DNA polymerase kappa isoform 1	10	0	0	10
Protoporphyrinogen oxidase, mitochondrial	0	1	0	1
Protoporphyrinogen oxidase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	11	0	0	11
NPYLR7B	0	0	1	1
arylsulfatase A	10	0	0	10
IDH1	11	0	0	11
Histone H2A.x	10	0	0	10
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	7	0	0	7
flap endonuclease 1	11	0	0	11
nuclear receptor ROR-gamma isoform 1	8	0	0	8
peripheral myelin protein 22	14	0	0	14
survival motor neuron protein isoform d	9	0	0	9
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Rap guanine nucleotide exchange factor 3	4	0	0	4
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	5	2	8
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	9	0	0	9
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	4	2	8
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	5	4	11
Adenosine receptor A2b	0	1	1	4
Adenosine receptor A2b	0	3	1	5
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	3	9
Adenosine receptor A2a	0	3	2	8
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	2	1	3
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Carbonic anhydrase 1	0	4	0	10
Carbonic anhydrase 2	0	5	0	12
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	3
Glutamate receptor ionotropic, NMDA 1	0	3	0	5
Proton-coupled amino acid transporter 1	0	4	0	5
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
interleukin 8	8	0	0	8
thyroid stimulating hormone receptor	20	0	0	20
euchromatic histone-lysine N-methyltransferase 2	33	0	0	33
Bloom syndrome protein isoform 1	15	0	0	15
transcriptional regulator ERG isoform 3	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
lamin isoform A-delta10	31	0	0	31
ATP-binding cassette sub-family C member 3	0	25	0	25
Multidrug resistance-associated protein 4	0	25	0	26
Polyphenol oxidase 2	0	2	0	2
Bile salt export pump	0	36	0	36
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	0	3
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Canalicular multispecific organic anion transporter 1	0	25	0	25
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain A, Beta-lactamase	10	0	0	10
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
Gamma-aminobutyric acid receptor subunit rho-1	0	1	2	3
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	5	0	0	5
15-lipoxygenase, partial	2	0	0	2
phosphopantetheinyl transferase	12	0	0	12
USP1 protein, partial	16	0	0	16
Microtubule-associated protein tau	15	0	0	15
thioredoxin glutathione reductase	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	21	0	0	21
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
cytochrome P450 3A4 isoform 1	14	0	0	14
histone acetyltransferase KAT2A isoform 1	8	0	0	8
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	2	0	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	14	8	2	24
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Prostaglandin G/H synthase 1	0	0	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	2	0	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Aromatase	0	3	0	3
Tissue factor	0	3	0	3
Fatty acid-binding protein, adipocyte	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	14	8	2	24
Gamma-aminobutyric acid receptor subunit delta	14	8	2	24
Gamma-aminobutyric acid receptor subunit gamma-2	14	8	3	25
Gamma-aminobutyric acid receptor subunit alpha-5	14	8	2	24
Gamma-aminobutyric acid receptor subunit alpha-3	14	8	2	24
Gamma-aminobutyric acid receptor subunit gamma-1	14	8	2	24
Gamma-aminobutyric acid receptor subunit alpha-2	14	8	2	24
Gamma-aminobutyric acid receptor subunit alpha-4	14	8	2	24
Gamma-aminobutyric acid receptor subunit gamma-3	14	8	2	24
Gamma-aminobutyric acid receptor subunit alpha-6	14	8	2	24
Prostaglandin G/H synthase 2	0	0	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Histamine H2 receptor	7	2	1	10
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	14	8	3	25
Gamma-aminobutyric acid receptor subunit beta-3	14	8	2	24
Gamma-aminobutyric acid receptor subunit beta-2	14	8	3	25
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Prostaglandin G/H synthase 2	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	3	0	3
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
GABA theta subunit	14	8	2	24
Gamma-aminobutyric acid receptor subunit epsilon	14	8	2	24
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	15	0	0	15
NFKB1 protein, partial	5	0	0	5
GLS protein	11	0	0	11
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	5	0	0	5
DNA polymerase iota isoform a (long)	12	0	0	12
muscarinic acetylcholine receptor M1	13	0	0	13
lethal factor (plasmid)	7	0	0	7
Cytochrome P450 3A4	0	9	0	10
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	15	0	0	15
Chain A, Putative fructose-1,6-bisphosphate aldolase	9	0	0	9
Caspase-7	1	0	0	1
Inositol monophosphatase 1	5	0	0	5
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
RAR-related orphan receptor gamma	21	0	0	21
thyroid stimulating hormone receptor	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
thyroid hormone receptor beta isoform a	9	0	0	9
DNA polymerase beta	4	0	0	4
Potassium channel subfamily K member 2	0	2	2	4
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	5	3	8
Replicase polyprotein 1ab	0	5	3	8
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	3	0	3
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	2	0	3
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Guanine deaminase	0	1	0	1
acetylcholinesterase	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
Vpr	4	0	0	4
Bile salt export pump	0	7	0	7
Albumin	0	0	4	4
Major prion protein	0	0	3	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
Cytochrome P450 2C9	0	13	1	14
UDP-glucuronosyltransferase 2B7	0	5	0	8
Cytochrome P450 2B6	0	1	1	2
Sodium channel protein type 4 subunit alpha	0	4	0	6
Cytochrome P450 2J2	0	6	0	6
Potassium voltage-gated channel subfamily H member 2	0	13	0	13
Sodium channel protein type 9 subunit alpha	0	5	0	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
PPM1D protein	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	2	3	5
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Amyloid-beta precursor protein	1	3	0	4
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	2	3	5
Muscarinic acetylcholine receptor M2	0	8	0	8
Muscarinic acetylcholine receptor M4	0	8	0	8
Muscarinic acetylcholine receptor M5	0	8	0	8
Alpha-2A adrenergic receptor	0	7	0	7
Replicase polyprotein 1a	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Spike glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	7	2	10
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	0	3
Alpha-2B adrenergic receptor	0	9	0	9
Alpha-2C adrenergic receptor	0	7	0	7
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	8	0	8
Beta-secretase 1	0	2	0	2
Spike glycoprotein	10	2	3	15
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	6	0	6
Angiotensin-converting enzyme 2	0	2	3	5
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Proteasome subunit beta type-11	0	0	0	1
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	5	0	0	5
Thrombopoietin	2	0	0	2
Smad3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	7	0	0	7
NADPH oxidase 1	0	1	0	1
polyprotein	5	0	0	5
67.9K protein	7	0	0	7
Snq2p	0	0	0	1
caspase-3	7	0	0	7
Adenylate cyclase type 1	0	2	0	2
Caspase-7	2	0	0	2
cytochrome P450 2D6 isoform 1	5	0	0	5
D(1A) dopamine receptor	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
M-phase phosphoprotein 8	7	0	0	7
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	7	0	7
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	6	0	6
Albumin	0	2	4	6
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Integrin beta-3	1	0	0	1
Cytochrome P450 1A2	0	1	1	2
Tyrosine-protein kinase Fyn	0	2	0	2
Aldo-keto reductase family 1 member B1	0	7	0	7
ATP-dependent translocase ABCB1	0	4	0	6
Muscarinic acetylcholine receptor M1	0	3	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Muscarinic acetylcholine receptor M4	0	3	0	3
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 1A	0	2	1	3
5-hydroxytryptamine receptor 2C	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Cytochrome P450 2D6	0	4	1	5
Muscarinic acetylcholine receptor M2	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Angiotensin-converting enzyme	0	3	0	3
D(2) dopamine receptor	0	4	0	5
5-hydroxytryptamine receptor 2A	0	5	0	5
Alpha-1B adrenergic receptor	0	5	0	5
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	6	1	7
Alpha-2B adrenergic receptor	0	3	0	3
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	4	0	5
D(4) dopamine receptor	0	4	0	5
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	4	0	6
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	3	0	3
Sodium-dependent noradrenaline transporter	0	7	1	8
Sodium-dependent dopamine transporter	0	3	0	3
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	7	0	7
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
5-hydroxytryptamine receptor 1B	0	2	0	2
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H1 receptor	0	2	1	3
Sodium-dependent serotonin transporter	0	6	0	6
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Histamine H1 receptor	0	4	1	5
Mu-type opioid receptor	0	7	1	8
D(3) dopamine receptor	0	4	0	5
Sodium channel protein type 1 subunit alpha	0	3	0	3
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	7	0	7
5-hydroxytryptamine receptor 2B	0	6	0	6
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	6	0	6
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	5	0	5
5-hydroxytryptamine receptor 7	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	4	1	6
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	3
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	3
Nuclear receptor subfamily 3 group C member 3	0	3	0	3
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	3
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	1	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 6	0	4	0	5
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Potassium-transporting ATPase alpha chain 1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	1	3
Potassium-transporting ATPase subunit beta	0	2	0	2
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 1	0	2	0	2
Multidrug and toxin extrusion protein 2	0	2	0	2
Solute carrier family 22 member 8	0	2	0	4
Multidrug and toxin extrusion protein 1	0	5	0	5
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-4	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	2
Neuronal acetylcholine receptor subunit beta-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	2	8
Gamma-aminobutyric acid receptor subunit beta-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	2	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	6	2	8
Translocator protein	0	1	0	1
Translocator protein	0	3	1	5
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-2	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	2	7
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	5	2	7
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
glycogen synthase kinase-3 alpha	0	0	0	1
muscleblind-like protein 1 isoform 1	5	0	0	5
Exportin-1	0	1	0	1
Carbonic anhydrase 12	0	2	0	6
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	2	0	4
Cytochrome P450 2A6	0	1	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	4	0	5
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	5	0	6
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	3	0	6
Carbonic anhydrase 6	0	2	0	5
Substance-P receptor	0	3	0	4
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
UDP-glucuronosyltransferase 2B10	0	4	0	4
Carbonic anhydrase 7	0	2	0	5
Quinone oxidoreductase	0	0	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	3	0	8
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 15	0	1	0	3
Carbonic anhydrase 13	0	2	0	5
Carbonic anhydrase 14	0	2	0	5
Carbonic anhydrase 5B, mitochondrial	0	2	0	5
Deoxycytidine kinase	0	0	0	1
activating transcription factor 6	10	0	0	10
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
Myeloperoxidase	0	3	0	3
Dihydrofolate reductase	0	4	0	5
Nuclear receptor ROR-gamma	5	0	0	5
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
apical membrane antigen 1, AMA1	4	0	0	4
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
Lysine-specific demethylase 4A	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	5
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Sex hormone-binding globulin	0	0	2	2
acid sphingomyelinase	2	0	0	2
WRN	2	0	0	2
Oligo-1,6-glucosidase IMA1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
endonuclease IV	5	0	0	5
peripheral myelin protein 22 isoform 1	7	0	0	7
Luciferase	6	0	0	6
lysosomal alpha-glucosidase preproprotein	5	0	0	5
Cytochrome P450 2B1	0	1	0	1
Estrogen receptor	1	4	2	7
Glucocorticoid receptor	1	4	2	9
Glycine receptor subunit alpha-1	0	4	0	4
Androgen receptor	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Glycine receptor subunit alpha-3	0	4	0	4
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	2	0	2
Estrogen receptor beta	1	3	2	6
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
glp-1 receptor, partial	5	0	0	5
Skn7p	0	0	0	1
EWS/FLI fusion protein	13	0	0	13
nonstructural protein 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	2	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Ferritin light chain	6	0	0	6
glucocerebrosidase	1	0	0	1
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	2	1	3
Alpha-synuclein	1	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
aryl hydrocarbon receptor	6	0	0	6
thyrotropin-releasing hormone receptor	2	0	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
neuropeptide S receptor isoform A	4	0	0	4
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Histone deacetylase 4	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Histone deacetylase 6	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Heme oxygenase 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	2
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	5	0	5
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Stromelysin-1	0	1	1	2
Urease subunit alpha	0	2	0	2
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
Delta-aminolevulinic acid dehydratase	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
ClpP	2	0	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	3	0	3
Translocator protein	0	3	1	4
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Glucocorticoid receptor	0	1	0	1
dopamine D1 receptor	4	0	0	4
hypothetical protein, conserved	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Progesterone receptor	0	2	1	5
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	1	1	3
Glucocorticoid receptor	0	1	0	1
Mineralocorticoid receptor	1	2	1	5
Androgen receptor	1	2	1	4
Cytochrome P450 2C8	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Progesterone receptor	0	0	1	1
Glucocorticoid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Neurotensin receptor type 1	0	0	1	1
Neurotensin receptor type 2	0	1	1	3
Myelin basic protein	0	0	1	1
Neurotensin receptor type 1	0	1	1	2
Neurotensin receptor type 1	0	2	2	5
Neurotensin receptor type 2	0	2	1	3
Sortilin	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
5-hydroxytryptamine receptor 3E	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Transporter	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Transporter	0	1	0	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	2	0	0	2
serine/threonine-protein kinase PLK1	3	0	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Cytochrome P450 2C19	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Leukotriene A-4 hydrolase	0	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Parkin	1	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
Macrophage migration inhibitory factor	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
SUMO-1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
pyruvate kinase	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
POsterior Segregation	0	0	1	1
chaperonin GroEL	1	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Exoribonuclease H	0	1	0	1
Coproheme decarboxylase	0	0	1	1
Protease	0	4	2	6
Single-stranded DNA cytosine deaminase	1	0	0	1
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Pyridoxal kinase	0	0	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
Thymidine phosphorylase	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	4	0	4
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Reverse transcriptase/RNaseH	0	1	2	6
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (160)

Protein Targets (1,001)

Hepatic Porphyria

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (160)

Drugs Studied (132)

Protein Targets (1,001)