Page last updated: 2024-08-07 23:17:59
Acetyl-CoA carboxylase 1
An acetyl-CoA carboxylase 1 that is encoded in the genome of rat. [OMA:P11497, PRO:DNx]
Synonyms
ACC1;
EC 6.4.1.2;
ACC-alpha
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.Journal of medicinal chemistry, , Dec-23, Volume: 53, Issue:24, 2010
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 20, Issue:7, 2010
Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 19, Issue:23, 2009
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.Journal of medicinal chemistry, , Jun-29, Volume: 49, Issue:13, 2006