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3,4-dihydroxybenzohydroxamic acid and AIDS, Murine

3,4-dihydroxybenzohydroxamic acid has been researched along with AIDS, Murine in 5 studies

Research Excerpts

ExcerptRelevanceReference
" In this study, the novel RR inhibitors didox (DX; 3,4-dihydroxybenzohydroxamic acid), and trimidox (TX; 3,4,5-trihydroxybenzamidoxime) were evaluated along with HU for anti-retroviral efficacy in LPBM5-induced retro-viral disease (MAIDS) both as monotherapeutic regimens and in combination with the guanine containing NRTI abacavir (ABC)."1.32In vivo examination of hydroxyurea and the novel ribonucleotide reductase inhibitors trimidox and didox in combination with the reverse transcriptase inhibitor abacavir: suppression of retrovirus-induced immunodeficiency disease. ( Duvall, W; Elford, HL; Gallicchio, VS; Hagan, E; Inayat, MS; Mayhew, CN; Sumpter, LR; Yost, EE, 2004)
" However, appeal for the long-term use of HU in HIV-1 infection may be limited by its propensity to induce hematopoietic toxicity."1.31Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea. ( Ahmed, MM; Chendil, D; Elford, HL; Gallicchio, VS; Greenberg, RN; Mampuru, LJ; Mayhew, CN; Phillips, JD, 2002)
" We examined a new series of RRIs, 3,4-dihydroxybenzohydroxamic acid (Didox) and 3,4,5-trihydroxybenzohydroxamidoxime (Trimidox) for their ability to alter disease progression in murine acquired immunodeficiency syndrome (MAIDS), both alone and in combination with 2',3'-dideoxyinosine (ddI)."1.30Effective use of ribonucleotide reductase inhibitors (Didox and Trimidox) alone or in combination with didanosine (ddI) to suppress disease progression and increase survival in murine acquired immunodeficiency syndrome (MAIDS). ( Birch, NJ; Elford, HL; Gallicchio, VS; Hughes, NK; Mayhew, C; Oakley, O; Phillips, J; Piper, J, 1997)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mayhew, CN3
Mampuru, LJ1
Chendil, D1
Ahmed, MM1
Phillips, JD2
Greenberg, RN1
Elford, HL4
Gallicchio, VS4
Sumpter, LR1
Inayat, MS1
Yost, EE1
Duvall, W1
Hagan, E1
Sumpter, R1
Inayat, M1
Cibull, M1
Mayhew, C1
Oakley, O1
Piper, J1
Hughes, NK1
Phillips, J1
Birch, NJ1
Smart, T1

Other Studies

5 other studies available for 3,4-dihydroxybenzohydroxamic acid and AIDS, Murine

ArticleYear
Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea.
    Antiviral research, 2002, Volume: 56, Issue:2

    Topics: Animals; Benzamidines; Bone Marrow Cells; DNA, Viral; Female; Femur; Free Radical Scavengers; Hemato

2002
In vivo examination of hydroxyurea and the novel ribonucleotide reductase inhibitors trimidox and didox in combination with the reverse transcriptase inhibitor abacavir: suppression of retrovirus-induced immunodeficiency disease.
    Antiviral research, 2004, Volume: 62, Issue:3

    Topics: Animals; Antiviral Agents; Benzamidines; Bone Marrow Cells; Dideoxynucleosides; Disease Models, Anim

2004
Combination of inhibitors of lymphocyte activation (hydroxyurea, trimidox, and didox) and reverse transcriptase (didanosine) suppresses development of murine retrovirus-induced lymphoproliferative disease.
    Antiviral research, 2005, Volume: 65, Issue:1

    Topics: Animals; Antiviral Agents; B-Lymphocytes; Benzamidines; Didanosine; Drug Therapy, Combination; Enzym

2005
Effective use of ribonucleotide reductase inhibitors (Didox and Trimidox) alone or in combination with didanosine (ddI) to suppress disease progression and increase survival in murine acquired immunodeficiency syndrome (MAIDS).
    Cellular and molecular biology (Noisy-le-Grand, France), 1997, Volume: 43, Issue:7

    Topics: Animals; Antiviral Agents; Benzamidines; Biomarkers; Didanosine; Disease Progression; Drug Therapy,

1997
Beyond hydroxyurea.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1995, Volume: 9, Issue:9

    Topics: Animals; Antiviral Agents; Benzamidines; Dipyridamole; Disease Models, Animal; Floxuridine; Fluorour

1995