fluorouracil has been researched along with Bowen Disease in 49 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of arsenical keratosis with multiple lesions of Bowen's disease and squamous cell carcinoma is described." | 7.72 | Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil. ( Khandpur, S; Sharma, VK, 2003) |
| "A case of arsenical keratosis with multiple lesions of Bowen's disease and squamous cell carcinoma is described." | 3.72 | Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil. ( Khandpur, S; Sharma, VK, 2003) |
| "An alternative approach to anal Bowen's disease was investigated." | 2.71 | Topical 5-fluorouracil in the management of extensive anal Bowen's disease: a preferred approach. ( Arnold, LK; Foote, JE; Graham, BD; Jetmore, AB, 2005) |
| "In general, people with Bowen's disease have an excellent prognosis because the disease is typically slow-growing and responds favourably to treatment." | 2.49 | Interventions for cutaneous Bowen's disease. ( Bath-Hextall, FJ; Leonardi-Bee, J; Matin, RN; Wilkinson, D, 2013) |
| "The lesions of Bowen's disease are slow-growing, erythematous scaly skin plaques that cause few, if any, symptoms." | 2.42 | Management of Bowen's disease of the skin. ( , 2004) |
| "An early diagnosis and treatment of Bowen's disease is important for preventing its progression to invasive epidermoid carcinoma and later dissemination." | 2.39 | [Bowen's disease. A report of 9 cases]. ( Borbujo Martínez, J; de Miguel Sánchez, C; Gázquez Abad, I; Olmos Carrasco, O; Rodríguez García, MD; Sáez-Berlana, A, 1994) |
| "Non-melanoma skin cancer (NMSC), which includes both Bowen's disease (BD) and superficial basal cell carcinoma (sBCC), is the most commonly diagnosed cancer in Canada." | 1.91 | Cryosurgery and 5-Fluorouracil Combination Therapy for Treatment of Bowen's Disease and Superficial Basal Cell Carcinoma. ( Nazarali, S; Sajic, D, 2023) |
| "Twenty-six patients with biopsy-proven Bowen's disease received eight 5-FU iontophoretic treatments in 4 weeks." | 1.30 | 5-fluorouracil iontophoretic therapy for Bowen's disease. ( Anderson, LL; Grabski, WJ; McCollough, ML; Menon, PA; Skelton, HG; Smith, KJ; Welch, ML, 1997) |
| "These guidelines for management of Bowen's disease have been prepared for dermatologists on behalf of the British Association of Dermatologists." | 1.30 | Guidelines for management of Bowen's disease. British Association of Dermatologists. ( Cox, NH; Eedy, DJ; Morton, CA, 1999) |
| "A histologically confirmed case of Bowen's disease in multiple nail beds in the hands of a 40-year-old is reported." | 1.27 | Bowen's disease in multiple nail beds--case report. ( Strong, ML, 1983) |
| "In white persons, most skin cancer occurs in sites that have been exposed to sunlight for long periods." | 1.26 | Dysplastic epidermal keratosis in a black woman. ( Kelly, AP; Lopansri, S; Weaver, SM, 1981) |
| "Sixty-six confirmed cases of Bowen's disease (intraepidermal squamous cell carcinoma) were seen from 1965 through 1976: twenty-four cases were treated surgically-four by excision (two recurrences) and twenty by desiccation and curettage (four recurrences); one was treated with x-ray radiation; and forty-one were treated with topical 5-fluorouracil (5-FU) (three recurrences)." | 1.26 | Bowen's disease and 5-fluorouracil. ( Sturm, HM, 1979) |
| "A case of extensive Bowen's disease of the skin treated successfully with topical 5-fluor-uracil is described." | 1.26 | [Therapy of morbus Bowen with 5-fluoro-uracil ointment (author's transl)]. ( Grussendorf, EI; Krause, H, 1979) |
| "The 12th case of Bowen's disease, presented here, offers an alternative method of treatment using 5-fluorouracil combined with a keratolytic ointment." | 1.26 | Bowen's disease of the nail bed: a case presentation and review of the literature. ( Defiebre, BK, 1978) |
| "Four cases of Bowen's disease of the finger have been treated, three during the past two years." | 1.26 | Bowen's Disease of the Finger. ( Kern, AB; Schiff, BL, 1977) |
| "An ususual case of Bowen's disease of the skin of the penile shaft treated successfully with topical 5-fluorouracil is presented along with a review of different modes of treatment." | 1.26 | Bowen's disease of shaft of penis. Successful treatment with 5-fluorouracil. ( Castro, VL; Mouded, IM; Newman, HR; Tolia, BM, 1976) |
| ""Bowen's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma." | 1.26 | Treatment of Bowen's disease with topical dinitrochlorobenzene and 5-fluorouracil. ( Cunningham-Rundles, W; Krown, SE; Oettgen, HF; Pinsky, CM; Raaf, JH; Safai, B, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (32.65) | 18.7374 |
| 1990's | 6 (12.24) | 18.2507 |
| 2000's | 16 (32.65) | 29.6817 |
| 2010's | 8 (16.33) | 24.3611 |
| 2020's | 3 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Nazarali, S | 1 |
| Sajic, D | 1 |
| Mohandas, P | 1 |
| Lowden, M | 1 |
| Varma, S | 1 |
| Lakhani, R | 1 |
| Khullar, G | 1 |
| Sharma, S | 1 |
| Saxena, AK | 1 |
| Bhargava, A | 1 |
| Jansen, MH | 1 |
| Appelen, D | 1 |
| Nelemans, PJ | 1 |
| Winnepenninckx, VJ | 1 |
| Kelleners-Smeets, NWJ | 1 |
| Mosterd, K | 1 |
| Uzunçakmak, TK | 1 |
| Cebeci, F | 1 |
| Dağdelen, D | 1 |
| Gürel, MS | 1 |
| Zenginkinet, T | 1 |
| Akdeniz, N | 1 |
| Verhave, B | 1 |
| Goldberg, M | 1 |
| Hashim, P | 1 |
| Levitt, J | 1 |
| Bath-Hextall, FJ | 1 |
| Matin, RN | 1 |
| Wilkinson, D | 1 |
| Leonardi-Bee, J | 1 |
| Morton, CA | 6 |
| Birnie, AJ | 1 |
| Eedy, DJ | 3 |
| Gibbs, S | 1 |
| Davis, T | 1 |
| Modi, G | 1 |
| Jacobs, AA | 1 |
| Orengo, IF | 1 |
| McClung, A | 1 |
| Rosen, T | 1 |
| Sharkawi, E | 1 |
| Hamedani, M | 1 |
| Fouladi, M | 1 |
| Salim, A | 1 |
| Leman, JA | 1 |
| McColl, JH | 1 |
| Chapman, R | 1 |
| Ramrakha-Jones, VS | 1 |
| Herd, RM | 1 |
| Dummer, R | 1 |
| Beyeler, M | 1 |
| Morcinek, J | 1 |
| Burg, G | 1 |
| Khandpur, S | 1 |
| Sharma, VK | 1 |
| Wang, KH | 1 |
| Fang, JY | 1 |
| Hu, CH | 1 |
| Lee, WR | 1 |
| Graham, BD | 1 |
| Jetmore, AB | 1 |
| Foote, JE | 1 |
| Arnold, LK | 1 |
| Cox, NH | 2 |
| Moreno, G | 1 |
| Chia, AL | 1 |
| Lim, A | 1 |
| Shumack, S | 1 |
| Perrett, CM | 1 |
| McGregor, JM | 1 |
| Warwick, J | 1 |
| Karran, P | 1 |
| Leigh, IM | 1 |
| Proby, CM | 1 |
| Harwood, CA | 1 |
| Bielan, B | 1 |
| Duncan, AL | 1 |
| Bell, HK | 2 |
| Rogers, M | 1 |
| Strong, ML | 1 |
| Weaver, SM | 1 |
| Kelly, AP | 1 |
| Lopansri, S | 1 |
| Braun, M | 1 |
| Biediger, TL | 1 |
| Grabski, WJ | 2 |
| McCollough, ML | 2 |
| de Miguel Sánchez, C | 1 |
| Olmos Carrasco, O | 1 |
| Sáez-Berlana, A | 1 |
| Rodríguez García, MD | 1 |
| Gázquez Abad, I | 1 |
| Borbujo Martínez, J | 1 |
| Welch, ML | 1 |
| Skelton, HG | 1 |
| Smith, KJ | 2 |
| Menon, PA | 1 |
| Anderson, LL | 1 |
| Stone, N | 1 |
| Burge, S | 1 |
| Rhodes, LE | 1 |
| Germain, M | 1 |
| Skelton, H | 1 |
| Yesudian, PD | 1 |
| King, CM | 1 |
| Miki, Y | 1 |
| Kawatsu, T | 1 |
| Matsuda, H | 1 |
| Yamada, T | 1 |
| Kahata, A | 1 |
| Katz, H | 1 |
| Redding, KG | 1 |
| Heising, RA | 1 |
| Sturm, HM | 1 |
| Krause, H | 1 |
| Grussendorf, EI | 1 |
| Defiebre, BK | 1 |
| Kern, AB | 1 |
| Schiff, BL | 1 |
| Montes, LF | 1 |
| Tolia, BM | 1 |
| Castro, VL | 1 |
| Mouded, IM | 1 |
| Newman, HR | 1 |
| Raaf, JH | 1 |
| Krown, SE | 1 |
| Pinsky, CM | 1 |
| Cunningham-Rundles, W | 1 |
| Safai, B | 1 |
| Oettgen, HF | 1 |
| Iwai, Y | 1 |
| Someya, K | 1 |
| Moriya, K | 1 |
| Kobayakawa, H | 1 |
| Ohyama, T | 1 |
| Horii, A | 1 |
| Schmidt, KU | 1 |
| Wiskemann, A | 1 |
| Mensing, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Surgical Excision Versus Photodynamic Therapy and Topical 5-fluorouracil in Treatment of Bowen's Disease: a Multicenter Randomized Controlled Trial[NCT03909646] | Phase 4 | 250 participants (Anticipated) | Interventional | 2019-05-27 | Recruiting | ||
| A Multicenter Observational and Feasibility Study of Excision of Superficially Invasive Squamous Cell Carcinoma (SISCCA) of the Anal Canal and Perianus in HIV-Infected Persons[NCT02437851] | Phase 2 | 16 participants (Actual) | Interventional | 2015-04-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for fluorouracil and Bowen Disease
| Article | Year |
|---|---|
Interventions for cutaneous Bowen's disease.
Topics: Aminolevulinic Acid; Aminoquinolines; Antineoplastic Agents; Bowen's Disease; Cryotherapy; Fluoroura | 2013 |
[Cutaneous neoplasms].
Topics: Adjuvants, Immunologic; Aminoquinolines; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bio | 2003 |
Management of Bowen's disease of the skin.
Topics: Aged; Antimetabolites, Antineoplastic; Bowen's Disease; Costs and Cost Analysis; Cryotherapy; Fluoro | 2004 |
Methyl aminolaevulinate photodynamic therapy for Bowen's disease: a practical option?
Topics: Administration, Topical; Aminolevulinic Acid; Antimetabolites, Antineoplastic; Bowen's Disease; Cryo | 2005 |
Guidelines for management of Bowen's disease: 2006 update.
Topics: Adjuvants, Immunologic; Aminoquinolines; Bowen's Disease; Cautery; Cryotherapy; Curettage; Disease P | 2007 |
Therapeutic options for Bowen's disease.
Topics: Aminoquinolines; Antineoplastic Agents; Bowen's Disease; Cautery; Cryotherapy; Fluorouracil; Humans; | 2007 |
[Bowen's disease. A report of 9 cases].
Topics: Aged; Bowen's Disease; Diagnosis, Differential; Female; Fluorouracil; Humans; Male; Middle Aged; Neo | 1994 |
[A case of bowenoid papulosis of the penis].
Topics: Adult; Bowen's Disease; Carcinoma, Squamous Cell; Fluorouracil; Humans; Male; Ointments; Penis; Skin | 1989 |
4 trials available for fluorouracil and Bowen Disease
| Article | Year |
|---|---|
Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aminolevulinic Acid; Antimetabolites, Antineoplast | 2003 |
Topical 5-fluorouracil in the management of extensive anal Bowen's disease: a preferred approach.
Topics: Administration, Topical; Adult; Aged; Antimetabolites, Antineoplastic; Anus Neoplasms; Biopsy; Bowen | 2005 |
Topical photodynamic therapy for Bowen's disease.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Antimetabolites, Antin | 2005 |
Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy.
Topics: Administration, Topical; Aged; Aminolevulinic Acid; Antimetabolites, Antineoplastic; Bowen's Disease | 2007 |
37 other studies available for fluorouracil and Bowen Disease
| Article | Year |
|---|---|
Cryosurgery and 5-Fluorouracil Combination Therapy for Treatment of Bowen's Disease and Superficial Basal Cell Carcinoma.
Topics: Bowen's Disease; Carcinoma, Basal Cell; Cryosurgery; Fluorouracil; Humans; Retrospective Studies; Sk | 2023 |
Bowen's disease.
Topics: Aged; Bowen's Disease; Cautery; Cryotherapy; Curettage; Disease Management; Female; Fluorouracil; Hu | 2020 |
Verrucous Bowen's disease on the hand successfully treated with prolonged course of topical 5% 5-fluorouracil.
Topics: Bowen's Disease; Fluorouracil; Humans; Skin Neoplasms | 2021 |
Bowen's Disease: Long-term Results of Treatment with 5-Fluorouracil Cream, Photodynamic Therapy or Surgical Excision.
Topics: Administration, Cutaneous; Antimetabolites, Antineoplastic; Bowen's Disease; Fluorouracil; Humans; M | 2018 |
Brown papules on the penis.
Topics: Administration, Topical; Adult; Antimetabolites, Antineoplastic; Biopsy; Bowen's Disease; Fluorourac | 2018 |
Treatment of Arsenic-Induced Bowen’s Disease With Topical 5-Fluorouracil
Topics: Administration, Cutaneous; Administration, Oral; Antimetabolites, Antineoplastic; Arsenic; Bowen's D | 2019 |
British Association of Dermatologists' guidelines for the management of squamous cell carcinoma in situ (Bowen's disease) 2014.
Topics: Adjuvants, Immunologic; Aminoquinolines; Antimetabolites, Antineoplastic; Bowen's Disease; Cautery; | 2014 |
Usage and patient experience of 5% fluorouracil cream.
Topics: Antimetabolites, Antineoplastic; Bowen's Disease; Carcinoma, Basal Cell; Cost Control; Fluorouracil; | 2015 |
Combination therapy with imiquimod, 5-fluorouracil, and tazarotene in the treatment of extensive radiation-induced Bowen's disease of the hands.
Topics: Aminoquinolines; Antineoplastic Agents; Biopsy; Bowen's Disease; Dermatologic Agents; Dose-Response | 2010 |
Eyelid squamous cell carcinoma in situ treated with topical 5-fluorouracil.
Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Bowen's Disease; Eyelid Neoplasms; F | 2011 |
Treating Bowen's disease: a cost-minimization study.
Topics: Antimetabolites; Biopsy; Bowen's Disease; Cost-Benefit Analysis; Costs and Cost Analysis; Cryotherap | 2003 |
Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil.
Topics: Acitretin; Arsenic; Biopsy, Needle; Bowen's Disease; Carcinoma, Squamous Cell; Drug Therapy, Combina | 2003 |
Erbium:YAG laser pretreatment accelerates the response of Bowen's disease treated by topical 5-fluorouracil.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Bowen's Disease; Combined Modality Therapy | 2004 |
What's your assessment? Pyogenic granuloma.
Topics: Administration, Cutaneous; Aged, 80 and over; Antimetabolites, Antineoplastic; Bowen's Disease; Diag | 2007 |
5-Fluorouracil cream and leg ulceration.
Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Bowen's Disease; Female; Fluorouraci | 2007 |
Management of common skin tumours.
Topics: Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cryosurgery; Dermatitis, Seborrhei | 1980 |
Bowen's disease in multiple nail beds--case report.
Topics: Adult; Bowen's Disease; Carcinoma, Squamous Cell; Fingers; Fluorouracil; Humans; Male; Nails; Skin N | 1983 |
Dysplastic epidermal keratosis in a black woman.
Topics: Aged; Black People; Bowen's Disease; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Keratos | 1981 |
Chemosurgery and excess tissue.
Topics: Bowen's Disease; Carcinoma, Squamous Cell; Fluorouracil; Humans; Methods; Skin Neoplasms | 1980 |
Bilateral pigmented Bowen's disease of the lower lip.
Topics: Administration, Topical; Aged; Biopsy; Bowen's Disease; Fluorouracil; Humans; Immunohistochemistry; | 1995 |
5-fluorouracil iontophoretic therapy for Bowen's disease.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Bowen's Disease; Female; Fluorouracil; Hum | 1997 |
Bowen's disease of the leg treated with weekly pulses of 5% fluorouracil cream.
Topics: Aged; Aged, 80 and over; Bowen's Disease; Drug Administration Schedule; Female; Fluorouracil; Humans | 1999 |
Bowen's disease--a retrospective review of clinical management.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Bowen's Disease; Cautery; Cryothera | 1999 |
Guidelines for management of Bowen's disease. British Association of Dermatologists.
Topics: Antimetabolites; Bowen's Disease; Carcinoma, Squamous Cell; Cautery; Cryotherapy; Disease Progressio | 1999 |
Squamous cell carcinoma in situ (Bowen's disease) in renal transplant patients treated with 5% imiquimod and 5% 5-fluorouracil therapy.
Topics: Administration, Cutaneous; Aged; Aminoquinolines; Antineoplastic Agents; Bowen's Disease; Drug Admin | 2001 |
Allergic contact dermatitis from stearyl alcohol in Efudix cream.
Topics: Aged; Bowen's Disease; Dermatitis, Allergic Contact; Fatty Alcohols; Female; Fluorouracil; Humans; K | 2001 |
[Topical chemotherapy for carcinoma of the skin (author's transl)].
Topics: Administration, Topical; Adolescent; Aged; Bleomycin; Bowen's Disease; Carcinoma, Basal Cell; Carcin | 1975 |
Therapeutic challenge of premalignant and malignant skin lesions.
Topics: Acetates; Adrenal Cortex Hormones; Adult; Aged; Balanitis; Bowen's Disease; Clioquinol; Cryosurgery; | 1975 |
Treatment of Bowen's disease of the ear by the combined use of cryosurgery and topical 5-fluorouracil.
Topics: Administration, Topical; Bowen's Disease; Carcinoma, Squamous Cell; Cryosurgery; Ear Neoplasms; Ear, | 1979 |
Bowen's disease and 5-fluorouracil.
Topics: Administration, Topical; Adult; Aged; Bowen's Disease; Carcinoma, Squamous Cell; Female; Fluorouraci | 1979 |
[Therapy of morbus Bowen with 5-fluoro-uracil ointment (author's transl)].
Topics: Bowen's Disease; Carcinoma, Squamous Cell; Cicatrix; Fluorouracil; Humans; Male; Skin Neoplasms; Tim | 1979 |
Bowen's disease of the nail bed: a case presentation and review of the literature.
Topics: Bowen's Disease; Carcinoma, Squamous Cell; Dermatologic Agents; Fluorouracil; Humans; Keratolytic Ag | 1978 |
Bowen's Disease of the Finger.
Topics: Adult; Aged; Bowen's Disease; Carcinoma, Squamous Cell; Female; Fingers; Fluorouracil; Humans; Male; | 1977 |
Bowen's disease.
Topics: Aged; Bowen's Disease; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Skin; Skin Neoplasms | 1977 |
Bowen's disease of shaft of penis. Successful treatment with 5-fluorouracil.
Topics: Administration, Topical; Adult; Bowen's Disease; Carcinoma, Squamous Cell; Fluorouracil; Humans; Mal | 1976 |
Treatment of Bowen's disease with topical dinitrochlorobenzene and 5-fluorouracil.
Topics: Arsenicals; Bowen's Disease; Carcinoma, Squamous Cell; Dinitrochlorobenzene; Fluorouracil; Humans; I | 1976 |
[Etretinate and 5-fluorouracil in intra-anal Bowen's disease].
Topics: Adult; Anal Canal; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Bowen's Disease; | 1986 |