Page last updated: 2024-12-04
racepinephrine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
Racepinephrine: A racemic mixture of d-epinephrine and l-epinephrine. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol : A catecholamine in which the aminoethyl side-chain is hydroxy-substituted at C-1 and methylated on nitrogen. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 838 |
| CHEMBL ID | 1740 |
| CHEBI ID | 33568 |
| CHEBI ID | 194548 |
| SCHEMBL ID | 3815 |
| MeSH ID | M0007589 |
Synonyms (130)
| Synonym |
|---|
| AC-395 |
| gtpl509 |
| 4-(1-hydroxy-2-methylaminoethyl)benzene-1,2-diol |
| (plusmn)-adrenaline |
| NCIOPEN2_000082 |
| dl-adrenaline |
| 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol |
| racepinefrinum |
| racepinefrine |
| (+-)-epinephrine |
| 2-(methylamino)-1-(3,4-dihydroxyphenyl)ethanol |
| epinephrine racemic |
| CHEBI:33568 , |
| (+-)-adrenaline |
| racepinefrina |
| racemic epinephrine |
| 1,2-benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)- |
| micronephrine |
| SGCUT00008 |
| ( )-epinephrine |
| brn 2212160 |
| (+-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol |
| racepinefrina [inn-spanish] |
| racepinephrine |
| (r,s)-3,4-dihydroxy-alpha-((methylamino)methyl)benzylalkohol |
| racepinefrinum [inn-latin] |
| 1,2-benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (+-)- |
| benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, (+-)- |
| epinephrine dl- |
| einecs 206-347-6 |
| 1-(3,4-dihydroxy)phenyl-2-methylaminoethanol |
| epirenamine |
| PDSP1_000587 |
| PDSP2_000584 |
| racepinephrine (usp/inn) |
| D05688 |
| 329-65-7 |
| LOPAC0_000522 |
| (+/-)-epinephrine, >=95% |
| TO_000046 |
| NCGC00162177-01 |
| inchi=1/c9h13no3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13h,5h2,1h |
| 9561B8BB-366F-4A33-B295-1C6E682AC6BB |
| A0172 |
| dl-epinephrine |
| NCGC00015417-03 |
| epinepherine |
| L000877 |
| l-(-)-epinephrine |
| FT-0695432 |
| CHEBI:194548 |
| chembl1740 , |
| HMS3259B19 |
| dl-adrenalin |
| AKOS005721043 |
| gr0l9s3j0f , |
| ccris 8140 |
| 4-13-00-02927 (beilstein handbook reference) |
| unii-gr0l9s3j0f |
| racepinefrine [inn] |
| racepinephrine [usp] |
| 4-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol |
| 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol;dl-adrenaline |
| A821533 |
| CCG-204612 |
| l(-)-epinephrine |
| SR-01000075862-8 |
| NCGC00015417-02 |
| STL146338 |
| FT-0625455 |
| epinephrine, dl- |
| epinephrine dl-form |
| S2523 |
| 6912-68-1 |
| (+/-)-epinephrine |
| benzyl alcohol, 3,4-dihydroxy-.alpha.-((methylamino)methyl)-, (+/-)- |
| racepinephrine [usp monograph] |
| epinephrine dl-form [mi] |
| racepinefrine [who-dd] |
| 8060-13-7 |
| HY-B0447 |
| NC00671 |
| BBL028091 |
| SCHEMBL3815 |
| (.+/-.)-3,4-dihydroxy-.alpha.-[(methylamino)methyl]benzyl alcohol |
| (.+/-.)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-benzenediol |
| (.+/-.)-epinephrine |
| (.+/-.)-adrenaline |
| 1,2-benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, (.+/-.)- |
| epinephrine dl form |
| benzyl alcohol, 3,4-dihydroxy-.alpha.-((methylamino)methyl)-, (.+/-.)- |
| (+/-)-epinephrine-2,5,6,alpha,beta,beta-d6 |
| cid_5924 |
| 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol, 1 |
| 4-[2-(methylamino)-1-oxidanyl-ethyl]benzene-1,2-diol;hydrochloride |
| bdbm84342 |
| 4-[1-hydroxy-2-(methylamino)ethyl]pyrocatechol;hydrochloride |
| epinephrine,(+) |
| AB00514461_07 |
| ( inverted exclamation marka)-adrenaline |
| dl-adrenali |
| ( inverted exclamation marka)-epinephrine |
| HMS3656E12 |
| 1,2-benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- |
| J-018952 |
| racemic adrenaline |
| epinephrine, racemic |
| hydrochloride, racepinephrine |
| adrenaline, racemic |
| BCP17220 |
| aroclor1016 |
| adrenaline,(s) |
| AS-12580 |
| (+/-)-adrenaline |
| Q7279006 |
| DTXSID80858965 , |
| 4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol |
| SDCCGSBI-0050505.P002 |
| NCGC00015417-16 |
| (+/-)-epinephrine;dl-adrenaline;(+/-)-adrenaline |
| D88221 |
| ()-epinephrine;dl-adrenaline;()-adrenaline |
| brn-2938799 |
| EN300-208482 |
| benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, (+/-)- |
| racepinephrine (usp monograph) |
| racepinephrine (usp) |
| racepinefrina (inn-spanish) |
| racepinefrinum (inn-latin) |
| dtxcid20196651 |
Research Excerpts
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| " We have described a patient in whom inadvertent intra-aortic administration of a large dose of racemic epinephrine produced serious adverse effects, including hypertension, acidemia, tachycardia, and protracted but reversible renal failure." | ( Renal failure and other serious sequelae of epinephrine toxicity in neonates. Levine, DH; Levkoff, AH; Pappu, LD; Purohit, DM, 1985) | 0.27 |
| "6 mg/kg dexamethasone PO, and mist, patients who were assessed as being safe for discharge after 3 hours of observation were discharged home and contacted for 48-hour follow-up." | ( Safety and efficacy of nebulized racemic epinephrine in conjunction with oral dexamethasone and mist in the outpatient treatment of croup. Ledwith, CA; Mauro, RD; Shea, LM, 1995) | 0.29 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " Increase in dosage resulted in a moderate elevation of heart rate without improvement in therapeutic action." | ( [Simple nebulization of racemic epinephrine in the treatment of acute laryngitis (croup) (author's transl)]. Zach, M, 1981) | 0.26 |
| " The highest dose used in the dose-response trials (=0." | ( Inhalation of racemic epinephrine in children with asthma. Dose-response relation and comparison with salbutamol. Kjellman, B; Tollig, H; Wettrell, G, 1980) | 0.26 |
| " When dosed appropriately, l-epinephrine is a less expensive and more widely available alternative to racemic epinephrine for the treatment of postextubation laryngeal edema." | ( Racemic versus l-epinephrine aerosol in the treatment of postextubation laryngeal edema: results from a prospective, randomized, double-blind study. Baldesare, KK; Brooks, LJ; Deakins, KM; Nutman, J; Reed, MD; Witte, MK, 1994) | 0.29 |
| " The correct dosage of dexamethasone is important, as lower steroid dosages have proven to be ineffective in treating croup." | ( Croup. Skolnik, N, 1993) | 0.29 |
| " Future studies need to examine dosing of glucocorticoids for inpatients with croup." | ( Recent advances in the treatment of bronchiolitis and laryngitis. Klassen, TP, 1997) | 0.3 |
| "Our objective was to determine if nebulized racemic epinephrine is more efficacious than nebulized albuterol or saline placebo in the treatment of bronchiolitis in the outpatient setting when dosing is equivalent in terms of beta-2 agonist potency." | ( Randomized, placebo-controlled trial of albuterol and epinephrine at equipotent beta-2 agonist doses in acute bronchiolitis. Anaya, T; Hartenberger, C; Kelly, HW; Qualls, C; Ralston, S, 2005) | 0.33 |
| " We performed logistic regression to identify factors associated with use of > 2 RE doses during hospitalization, and survival analysis to identify time to dosing of 3rd RE from 2nd RE." | ( Inpatient use of racemic epinephrine for children admitted with croup. Afandi, O; Chiang, E; Lee, SH; Pitetti, RD; Ramgopal, S; Suresh, S, 2019) | 0.51 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
| Class | Description |
|---|---|
| catecholamine | 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Pathways (1)
| Pathway | Proteins | Compounds |
|---|---|---|
| 22q11.2 copy number variation syndrome | 2 | 28 |
Protein Targets (14)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.3264 | 0.0052 | 1.3022 | 8.1995 | AID624455 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 2.3109 | 0.0184 | 6.8060 | 14.1254 | AID624148 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 5.9728 | 0.1000 | 20.8793 | 79.4328 | AID488773; AID588453 |
| GLS protein | Homo sapiens (human) | Potency | 5.6234 | 0.3548 | 7.9355 | 39.8107 | AID624146 |
| arylsulfatase A | Homo sapiens (human) | Potency | 30.1313 | 1.0691 | 13.9551 | 37.9330 | AID720538 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 1.2995 | 0.0058 | 6.0263 | 32.6427 | AID485366 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 0.6310 | 2.5119 | 13.8003 | 28.1838 | AID743205 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.9083 | 0.0224 | 5.9449 | 22.3872 | AID488982; AID488983 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 0.3548 | 28.0659 | 89.1251 | AID504847 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 0.6310 | 2.5119 | 13.8003 | 28.1838 | AID743205 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 3.3587 | 0.1337 | 25.4129 | 89.1251 | AID488816; AID588795 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 26.8545 | 0.4256 | 12.0591 | 28.1838 | AID504536 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Activation Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| NPYLR7B | Aedes aegypti (yellow fever mosquito) | EC50 (µMol) | 0.3270 | 0.0390 | 2.2899 | 18.3000 | AID1259426 |
| Beta-adrenergic receptor kinase 1 | Homo sapiens (human) | Kd | 0.6100 | 0.1700 | 5.5791 | 22.4940 | AID1799821 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (16)
Molecular Functions (8)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protein kinase activity | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| G protein-coupled receptor kinase activity | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| protein binding | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| ATP binding | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| alpha-2A adrenergic receptor binding | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| Edg-2 lysophosphatidic acid receptor binding | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| beta-adrenergic receptor kinase activity | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| G protein-coupled receptor binding | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (7)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| cytoplasm | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| cytosol | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| plasma membrane | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| cilium | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| membrane | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| presynapse | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| postsynapse | Beta-adrenergic receptor kinase 1 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Bioassays (22)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16 | Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | |||
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | |||
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500 | Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1346159 | Human alpha2C-adrenoceptor (Adrenoceptors) | 1998 | Biochemical pharmacology, Apr-01, Volume: 55, Issue:7 | Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. |
| AID1346058 | Human alpha2B-adrenoceptor (Adrenoceptors) | 1998 | Biochemical pharmacology, Apr-01, Volume: 55, Issue:7 | Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. |
| AID1346297 | Human beta3-adrenoceptor (Adrenoceptors) | 1993 | Molecular pharmacology, Dec, Volume: 44, Issue:6 | Structural and conformational features determining selective signal transduction in the beta 3-adrenergic receptor. |
| AID1347018 | Rat beta3-adrenoceptor (Adrenoceptors) | 1995 | European journal of pharmacology, Nov-30, Volume: 291, Issue:3 | Carazolol: a potent, selective beta 3-adrenoceptor agonist. |
| AID1346260 | Human beta1-adrenoceptor (Adrenoceptors) | 1988 | Proceedings of the National Academy of Sciences of the United States of America, Dec, Volume: 85, Issue:24 | Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. |
| AID1346297 | Human beta3-adrenoceptor (Adrenoceptors) | 2004 | Naunyn-Schmiedeberg's archives of pharmacology, Feb, Volume: 369, Issue:2 | Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. |
| AID1346297 | Human beta3-adrenoceptor (Adrenoceptors) | 1995 | European journal of pharmacology, Nov-30, Volume: 291, Issue:3 | Carazolol: a potent, selective beta 3-adrenoceptor agonist. |
| AID1346312 | Mouse beta3-adrenoceptor (Adrenoceptors) | 1995 | European journal of pharmacology, Nov-30, Volume: 291, Issue:3 | Carazolol: a potent, selective beta 3-adrenoceptor agonist. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1799821 | Inhibition Assay from Article : \\Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor.\\ | 1989 | The Journal of biological chemistry, Aug-15, Volume: 264, Issue:23 | Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (154)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 50 (32.47) | 18.7374 |
| 1990's | 39 (25.32) | 18.2507 |
| 2000's | 28 (18.18) | 29.6817 |
| 2010's | 21 (13.64) | 24.3611 |
| 2020's | 16 (10.39) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 48.83
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (48.83) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 43 (26.71%) | 5.53% |
| Reviews | 18 (11.18%) | 6.00% |
| Case Studies | 16 (9.94%) | 4.05% |
| Observational | 3 (1.86%) | 0.25% |
| Other | 81 (50.31%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Clinical Trials (204)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Saline Injection - Assisted Anesthesia in Eyelid Surgery [NCT01239498] | Phase 4 | 60 participants (Anticipated) | Interventional | 2010-11-30 | Recruiting | ||
| Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery: A Randomized Controlled Trial [NCT04427904] | Phase 2 | 210 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| ED50 and ED95 of Intrathecal Bupivacaine With or Without Epinephrine for Total Knee Replacement Arthroplasty [NCT01264575] | 162 participants (Actual) | Interventional | 2009-12-31 | Completed | |||
| Combined Subconjunctival Atropine and Intracameral Epinephrine Injection for Pupil Dilation in Phacoemulsification Under Peribulbar Anesthesia. [NCT03638726] | Phase 4 | 40 participants (Anticipated) | Interventional | 2018-09-28 | Recruiting | ||
| Antecubital Versus Femoral Approach for Adrenal Venous Sampling: A Randomised Controlled Trial [NCT06029803] | 154 participants (Anticipated) | Interventional | 2022-04-01 | Recruiting | |||
| Randomized Control Trial of Ultrasound-Guided Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Pain Control After Arthroscopic Shoulder Surgery [NCT03691922] | 62 participants (Actual) | Interventional | 2019-07-06 | Completed | |||
| Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization During General Anesthesia: A Randomized Controlled Double Blinded Study [NCT02368054] | Phase 4 | 34 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| Pilot Study: Comparison of Buffered 1% vs. Unbuffered 2% Lidocaine in Pediatric Subjects; Clinical Outcomes [NCT03562481] | Phase 4 | 26 participants (Actual) | Interventional | 2018-07-24 | Completed | ||
| Bioavailability Comparison of Epinephrine Following a Single Nasal Dose of Microspheres Powder With Epinephrine Intramuscular Injection in Adults With Seasonal Allergic Rhinitis With and Without Nasal Allergen Challenge [NCT04696822] | Phase 1 | 12 participants (Actual) | Interventional | 2020-11-01 | Completed | ||
| The Application of Recombinant Human Hyaluronidase is Effective for the Use of Local Blocks for Eyelid Surgery [NCT02059694] | 0 participants (Actual) | Interventional | Withdrawn | ||||
| Laparoscopically Guided Rectus Sheath Block in Pediatric Appendicitis - a Randomized Control Trial [NCT04717193] | Phase 2 | 100 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | ||
| The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine for Spinal Anesthesia in Total Knee Replacement Arthroplasty [NCT01261078] | 75 participants (Anticipated) | Interventional | 2010-12-31 | Completed | |||
| A Randomised Clinical Trial Comparing Endovenous Laser Ablation and Mechanochemical Ablation (ClariVein®) in the Management of Superficial Venous Insufficiency [NCT02627846] | Phase 4 | 150 participants (Actual) | Interventional | 2015-06-01 | Completed | ||
| The Effect of BMI on Median Effective Dose (ED50) of Intrathecal Hyperbaric Bupivacaine for Total Knee Replacement Arthroplasty [NCT01291186] | 108 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| Comparison of the Analgesic Effect of Femoral Nerve Block, Intraarticular Infiltration or a Combination of Both in the Control of Pain in Total Knee Arthroplasty [NCT01304212] | Phase 4 | 137 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Study of Drug Exposure in Systemic Circulation of Primatene Mist (0.25mg) by Oral Inhalation, Versus Epinephrine Injection (0.30mg) by Intramuscular Injection and ProAir (0.18mg) by Oral Inhalation in Healthy Individuals: A Randomized, Safety Evaluator-bl [NCT04207840] | Phase 4 | 28 participants (Actual) | Interventional | 2019-12-09 | Completed | ||
| Surgicel; a Probable Analgesic Reservoir for Post-laparoscopic Cholecystectomy Pain Management; Randomized Controlled Double-blind Trial [NCT03730714] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2018-11-15 | Completed | ||
| An Analysis of the Functional Benefit, Narcotic Use and Time to Discharge Readiness Following the Implementation of a Comprehensive Pain Management Protocol for Primary Total Knee Arthroplasty [NCT02474654] | Phase 4 | 220 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Comparing the Effect of 4% Articaine and 2% Mepivacaine Without Palatal Injection in Pain Assessment During Maxillary Teeth Extraction- A Randomized Clinical Trial [NCT03470532] | Phase 4 | 60 participants (Actual) | Interventional | 2017-02-25 | Completed | ||
| Comparison of Zero- and Two-centimeter Distance From Sapheno-femoral Junction in Laser Ablation of Long Saphenous Vein Incompetence: Evaluating the Kissing Technique [NCT05707169] | 800 participants (Anticipated) | Interventional | 2023-01-04 | Active, not recruiting | |||
| Managing Post Spinal Hypotension During Elective Cesarean Section: Epinephrine Versus Ephedrine, a Randomized Double-blinded Controlled Trial [NCT03704909] | Phase 4 | 143 participants (Actual) | Interventional | 2018-09-01 | Completed | ||
| Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension [NCT05439460] | Phase 4 | 15 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Adrenal Artery Ablation for Primary Aldosteronism：A Randomized, Parallel, Active-controlled Clinical Trial to Evaluate the Efficacy and Safety of Adrenal Artery Ablation（AAA）in the Treatment of Primary Aldosteronism [NCT03653845] | Phase 3 | 40 participants (Anticipated) | Interventional | 2018-07-01 | Recruiting | ||
| Comparison of the Effects of Two Concentrations of Adrenaline (0.33 mg/l vs 1 mg/l) in the Irrigation Serum of Arthroscopic Shoulder Surgery. [NCT05439213] | 170 participants (Anticipated) | Interventional | 2022-06-22 | Recruiting | |||
| Ultrasound-Guided Versus Conventional Method for Caudal Block in Children [NCT03427437] | 275 participants (Actual) | Interventional | 2017-02-01 | Completed | |||
| Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery [NCT02346110] | Phase 4 | 40 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| Nebulized Hypertonic Saline (3%) Versus Nebulized Adrenaline for Treatment of Bronchiolitis: A Randomized Control Trial [NCT03614273] | 60 participants (Actual) | Interventional | 2015-03-01 | Completed | |||
| An Exploratory Phase I Randomized, Single-site, Double-blind, Active-controlled, Parallel-group, Single-administration, Dose-escalation Trial to Investigate the Safety and Tolerability of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Wi [NCT03399435] | Phase 1 | 242 participants (Actual) | Interventional | 2018-01-30 | Terminated(stopped due to The sponsor decided to stop further dosing of healthy volunteers after reviewing the obtained efficacy data. The decision is not related to any safety concern.) | ||
| Pulpal Blood Flow With the Use of Intra-nasal Anesthetic: a Randomized Double-blind Crossover Study [NCT03368391] | Phase 4 | 25 participants (Anticipated) | Interventional | 2018-01-03 | Not yet recruiting | ||
| The Effect of Protracted Saphenous Nerve and Obturator Nerve Block Versus Saphenous Nerve Block Versus Local Infiltration Analgesia on Opioid Consumption, Pain, Block Duration of Action and Mobilization After Total Knee Arthroplasty. [NCT02067078] | Phase 4 | 75 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Efficacy of Lidocaine Saline Irrigation in Patients Undergoing Shoulder Arthroscopy: Randomized Controlled Study [NCT05624957] | 50 participants (Actual) | Interventional | 2022-11-25 | Completed | |||
| A Randomized, Double-blinded or Evaluator-blinded, Placebo and Active Controlled, Six-arm, Crossover, Single Dose, Dose-ranging Study, for Initial Evaluation of Safety and Efficacy in Asthma Patients [NCT01025648] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2009-12-31 | Terminated(stopped due to Optimization of protocol) | ||
| Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism [NCT02127840] | Phase 4 | 40 participants (Anticipated) | Interventional | 2011-03-31 | Recruiting | ||
| Three-level Injection Paravertebral Block Using Paravertebral Catheter Compared to General Anesthesia in Mastectomy Surgery [NCT02065947] | Phase 1/Phase 2 | 60 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| Effect of Local Infiltration Anesthesia in a Hip Arthroplasty Fast Track Program. [NCT03513276] | Phase 4 | 63 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Bacteraemia Secondary to Tooth Extraction: a Randomized Clinical Trial on Efficacy of Three Different Chlorhexidine Prophylaxis Protocols [NCT02150031] | Phase 4 | 208 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Epinephrine Inhalation Aerosol USP, an HFA-MDI: Clinical Study-C For Evaluation Of Efficacy And Safety In Asthma Patients [NCT01357642] | Phase 3 | 373 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| A 3-month Safety Evaluation Extension to the 12-week E004-C Study in Asthma Patients (A Double Blinded, Placebo-controlled, Parallel, 3-month Safety Study in Adolescent and Adult Patients With Asthma) [NCT01476904] | Phase 3 | 208 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| An Open, Randomised, Parallel Group Controlled, Single Centre Safety Study to Assess the Safety and Efficacy of Tri-Solfen in Providing Anaesthesia Prior to Surgical Debridement of Leg Ulcers and Post-operative Pain Relief [NCT03865147] | Phase 2 | 90 participants (Anticipated) | Interventional | 2019-01-15 | Recruiting | ||
| Randomized, Double Blind Trial of Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block for Adult Spinal Surgery [NCT03931343] | 60 participants (Anticipated) | Interventional | 2020-12-31 | Not yet recruiting | |||
| Local Infiltration Analgesia During Total Knee Arthroplasty - Reduced Opiate Consumption and Faster Mobilisation Postoperatively - Randomized Controlled Trial [NCT01305733] | 60 participants (Actual) | Interventional | 2011-03-31 | Active, not recruiting | |||
| Adrenal Venous Sampling Via an Antecubital Approach: A Multicenter Study [NCT03778645] | 1,500 participants (Anticipated) | Observational | 2018-07-01 | Recruiting | |||
| How Successful is Supplemental Intraseptal Anaesthesia in Patients With Mandibular Teeth Extraction or Irreversible Pulpitis [NCT03880409] | Phase 1 | 100 participants (Actual) | Interventional | 2019-02-09 | Completed | ||
| Formulations of Liposomal Local Anesthetics for Dental Anesthesia [NCT01307969] | Phase 1 | 40 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Comparison of Postoperative Pain With Two Different Types of Local Anesthesia in Surgery for a Drooping Eyelid [NCT01350024] | 34 participants (Actual) | Interventional | 2011-05-01 | Completed | |||
| Hypoglycemia Associated Autonomic Failure in Type 1 DM, Question 5 [NCT00605774] | 0 participants (Actual) | Interventional | Withdrawn | ||||
| Hypoglycemia Associated Autonomic Failure in Type 1 DM, Question 4 [NCT00608816] | 0 participants (Actual) | Interventional | Withdrawn | ||||
| Intraoperative Use of Perineal Block for Hemorrhoidectomy [NCT04288349] | 100 participants (Anticipated) | Interventional | 2020-02-20 | Recruiting | |||
| A Randomized, Single-Blinded, Placebo-Controlled Study Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation [NCT04814433] | Phase 4 | 5 participants (Actual) | Interventional | 2021-03-24 | Terminated(stopped due to Both lack of enrollment as well as study staff turnover) | ||
| Effectiveness of Bupivacaine With Epinephrine Injections Into the Uterosacral Ligaments for Post-operative Pain Control and the Use of Narcotic Pain Medication Following Robotic Assisted Total Hysterectomies [NCT02230735] | 0 participants (Actual) | Interventional | 2014-08-31 | Withdrawn(stopped due to Study was never started.) | |||
| Shamrock Versus Lumbar Ultrasound Trident - Ultrasound Guided Block of the Lumbar Plexus: A Randomized Controlled Trial [NCT02255591] | Phase 4 | 20 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Analgesic Benefit of PECS Blocks for Biceps Tenodesis Shoulder Surgery [NCT02741713] | Phase 3 | 40 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| A Randomized Comparison Between 1 Plane - 1 Injection (Cluster Approach) and 2 Plane - 2 Injection Ultrasound-guided Supraclavicular Brachial Plexus Block (US-SCBPB) in Upper Extremity Surgery [NCT02505633] | 36 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Postoperative Pain Management Following Total Hip Arthroplasty. A Comparison Between Local Infiltration Analgesia and Ultrasound Guided 3-in-1 Block [NCT02568995] | Phase 3 | 55 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Tumescent Lidocaine Bioavailability and Absorption Kinetics:Maximum Safe mg/kg Lidocaine Dosage [NCT00977028] | Phase 1/Phase 2 | 14 participants (Actual) | Interventional | 2005-01-31 | Enrolling by invitation | ||
| A Single Center, Prospective, Observational Study to Explore and Evaluate the Differences of Cognitive Function and Brain Function Between Non-functioning Adrenal Adenomas and Autonomous Cortisol Secretion Patients, and the Different Treatments Methods on [NCT05357456] | 62 participants (Anticipated) | Observational | 2021-10-01 | Recruiting | |||
| Towards Cost-effective Management of Patients With Hypertension Due to Primary Aldosteronism: Adrenal Vein Sampling or Ct-scan? [NCT01096654] | Phase 3 | 200 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Comparison of Perioperative Opioid Consumption Following Pectoral Nerve Block Under General Anesthesia for Breast Cancer Surgery: A Randomized Clinical Trial [NCT02741232] | 50 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| The Use of Tranexamic Acid in Irrigation Fluid to Improve Arthroscopic Visualization in Shoulder Surgery: A Randomized Controlled Trial [NCT04594408] | Phase 4 | 128 participants (Actual) | Interventional | 2020-09-01 | Active, not recruiting | ||
| Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty [NCT00562627] | Phase 4 | 102 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| Interest of the Alkalinization of the Adrenaline Lidocaine Solution for Conversion of Epidural Analgesia Into Epidural Anesthesia During an Emergency Caesarean [NCT04255121] | Phase 3 | 400 participants (Actual) | Interventional | 2020-06-22 | Completed | ||
| Randomized Controlled Trial of Dopamine, Adrenaline, and Blood Transfusion for Treatment of Fluid Refractory Shock in Children With Severe Acute Malnutrition or Severe Underweight and Cholera or Other Dehydrating Diarrheas [NCT04750070] | Phase 3 | 135 participants (Anticipated) | Interventional | 2021-08-17 | Recruiting | ||
| Randomized Double-blind Clinical Trial Comparing the Cardiovascular Effects of Local Anesthesia Solutions Containing 1:100,000 and 1:200,000 of Epinephrine Concentrations [NCT02735018] | Phase 4 | 40 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Effect of Intrapartum Epidural Fentanyl Upon Breastfeeding in the Immediate Postpartum Period: a Randomized, Controlled, Double-blinded Study [NCT01497509] | 0 participants (Actual) | Interventional | 2012-05-31 | Withdrawn(stopped due to Study never started) | |||
| Efficacy of Post-FESS Implantation of Composite Removable Sinus Stent System to Prevent Post-Operative Complications and Revision Surgery [NCT02812199] | 30 participants (Anticipated) | Interventional | 2016-08-31 | Recruiting | |||
| A Multi-center, Randomized, Double-blind, Crossover, phase4 Trial to Evaluate the Efficacy on Local Anesthesia and Safety of 2% Lidocaine HCl With Different Epinephrine Concentration in Patients Undergoing Surgical Extraction of Impacted Lower Third Molar [NCT02696369] | Phase 4 | 65 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Does the Addition of Epinephrine to Bilateral Ultrasound Guided Pterygopalatine Ganglion Block Reduce Bleeding During Functional Endoscopic Sinus Surgery (FESS)? A Pilot Study [NCT03970655] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2019-09-25 | Recruiting | ||
| Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death Without Definitive Causative Diagnosis (PEA-SuddenDeath) [NCT05446779] | 400 participants (Anticipated) | Observational | 2022-06-03 | Recruiting | |||
| A Randomized Comparison Between 1 Plane-2 Injection and 2 Plane-2 Injection Ultrasound-guided Supraclavicular Brachial Plexus Block (US-SCBPB) in Upper Extremity Surgery [NCT02533557] | 70 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| A Phase 1 Comparative Bioavailability Study of Inhaled Epinephrine and Intramuscular Epinephrine Administered to Healthy Adults [NCT05152901] | Phase 1 | 23 participants (Actual) | Interventional | 2022-01-06 | Completed | ||
| Intraoperative Injection of Exparel Effect on Postoperative Opioid Use in Thyroid and Parathyroid Surgery [NCT04085913] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2019-09-30 | Enrolling by invitation | ||
| ''To Compare the Response Rate of Noradrenaline vs. Terlipressin in Hepatorenal Syndrome in Patients With Acute on Chronic Liver Failure' [NCT02573727] | 120 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| Prospective, Randomized Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip Plus Epinephrine Injection in Nonvariceal Upper Gastrointestinal Bleeding [NCT02537353] | Phase 4 | 40 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting | ||
| Study of Tramadol Addiction Impact on Dental Anesthesia Succes. [NCT05908305] | Phase 4 | 300 participants (Anticipated) | Interventional | 2023-06-10 | Not yet recruiting | ||
| Vasopressin, Epinephrine, and Corticosteroids for Inhospital Cardiac Arrest: A Multicenter Randomized Controlled Trial [NCT00729794] | Phase 3 | 300 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| A Multicenter Double-Blind Randomized Placebo Controlled Two-Arm Study Evaluating the Safety and Efficacy of the Iontophoretic Administration of Lidocaine and Epinephrine Using Lidocaine Iontophoretic Drug Delivery System (IDDS) to Provide Local Anesthesi [NCT00889642] | Phase 2 | 90 participants (Anticipated) | Interventional | 2009-05-31 | Completed | ||
| Efficacy and Safety of Percutaneous Superselective Adrenal Arterial Embolization in the Treatment of Primary Aldosteronism With Bilateral Idiopathic Hyperaldosteronism: A Prospective Cohort Study [NCT05186675] | 50 participants (Anticipated) | Interventional | 2022-01-01 | Enrolling by invitation | |||
| Anesthetic Efficacy of %4Alexadricaine Versus %2 Mepicaine-L for Infiltration Anesthesia in Extraction of Maxillary First Primary Molars in Children [NCT04477317] | Phase 3 | 10 participants (Actual) | Interventional | 2021-08-01 | Completed | ||
| Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal Tumors [NCT02543697] | 30 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | |||
| Periarticular Injection and Hamstring Block Versus Placebo for Pain Control in Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial [NCT05248724] | 44 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| The Use of Epinephrine Infusion for Prophylaxis Against Maternal Hypotension During Cesarean Delivery: a Randomized Controlled Dose-finding Trial [NCT05051150] | Phase 4 | 18 participants (Actual) | Interventional | 2021-09-15 | Terminated(stopped due to tachycardia and arrhythmia in the high doses groups 0.05 and 0.07 necessitate stopping the infusion) | ||
| Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas [NCT02364089] | 78 participants (Actual) | Interventional | 2015-04-09 | Completed | |||
| Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue [NCT01949714] | 10 participants (Actual) | Observational | 2013-08-31 | Completed | |||
| The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery: Randomized Clinical Trial [NCT00852410] | Phase 3 | 140 participants (Anticipated) | Interventional | 2009-03-31 | Not yet recruiting | ||
| Pharmacokinetic Interaction Effects of Combined Fentanyl and Adrenalin in Epidural Analgesia During Child Birth [NCT00685672] | Phase 4 | 40 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| "Clinical Trial Protocol of Primary Study on Efficacy and Safety of Telesurgery for Patients With Tumors of the Urinary System Using Chinese Independently Developed MicroHand Surgical Robot System" [NCT04570176] | 1 participants (Actual) | Interventional | 2020-08-27 | Completed | |||
| Nebulized Adrenalin and Oral Betamethasone in Children With Bronchiolitis Attending Pediatric Emergencies : a Multicentre Randomized Controlled Trial [NCT02586961] | Phase 2/Phase 3 | 195 participants (Actual) | Interventional | 2015-10-31 | Terminated(stopped due to Removal of Adrénaline lots for safety reasons.) | ||
| 7% Hypertonic Saline for Acute Bronchiolitis: A Randomized Controlled Trial [NCT01871857] | Phase 4 | 101 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| Comparative Evaluation of Handling Characteristics of Two Adrenaline Autoinjectors,EpiPen in Comparison With Jext; the HEJ-study [NCT01887405] | Phase 4 | 91 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Assessment of the Operative Course in Connection With Removal of Lower Third Molars With Particular Consideration to the Occurence of Pain and Swelling [NCT00805298] | 154 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| Phase II Clinical Trial for a Stepwise Progression in the Treatment of Cardiogenic Shock [NCT02591771] | Phase 2 | 24 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? [NCT00817466] | Phase 4 | 500 participants (Anticipated) | Interventional | 2010-01-31 | Active, not recruiting | ||
| Hemostatic and Hemodynamic Effects of Intranasal Injection Compared to Topical Administration of Epinephrin in Endoscopic Sinus Surgery [NCT01075581] | 50 participants (Anticipated) | Interventional | 2010-04-30 | Not yet recruiting | |||
| Nebulized 5% Hypertonic Saline for Infirmary Treatment of Acute Infant Bronchiolitis: A Randomized Trial [NCT01016249] | Phase 4 | 187 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| Phase 2, Single-Center, Placebo-Controlled Study of the Effects of Combined Administration of Vasopressin, Methylprednisolone, and Epinephrine During Cardiopulmonary Resuscitation on Survival After Cardiac Arrest [NCT00411879] | Phase 2 | 100 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Anesthetic Efficacy of 4% Articaine (Mandibular Infiltration) and 2% Lidocaine (Alveolar Nerve Block), Associated With 1:100.000 Epinephrine, in Lower Molars With Irreversible Pulpits [NCT01912755] | Phase 4 | 50 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| Compare Articaine 1:100.000, 4% Epinephrine, Subperiosteal With Loco-regional Anesthesia for Placing Dental Implants in Posterior Mandible - Double-Blinded Randomized Clinical Trial [NCT01963754] | Phase 4 | 88 participants (Anticipated) | Interventional | 2017-04-01 | Active, not recruiting | ||
| Phase 4 Study of Comparison of Preincisional Infiltrated Dexmedetomidine and Lidocaine Plus Adrenaline for Surgical Conditions and Postoperative Analgesic Consumption in Nasal Sephoplasty Surgery. [NCT01964586] | Phase 4 | 60 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| The Effect of Topical Administration of Tranexamic Acid, Adrenaline and Bupivacain on Postoperative Bleeding and Pain in Patients Undergoing Breast Surgery. A Four-armed Placebo-controlled Double Blinded Randomized Study [NCT01964781] | Phase 4 | 30 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Does Saphenous Nerve Block Improve Analgesia After Total Knee Replacement When Used in Combination With Local Infiltration Analgesia? A Prospective Randomised Double Blinded Trial. [NCT01991288] | Phase 4 | 20 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| Regional Anesthesia Block of the Transversus Abdominis Plane in Children Undergoing Gastric Tube Insertion [NCT00564655] | Phase 3 | 3 participants (Actual) | Interventional | 2007-10-31 | Terminated | ||
| Phase I/II Study Epinephrine Inhalation Aerosol USP, an HFA-MDI Clinical Study-B for Assessment of Pharmacokinetics [NCT01143051] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Efficacy of Hemostasis by Soft Coagulation Using Endoscopic Hemostatic Forceps in Comparison With Argon Plasma Coagulation for Acute Peptic Ulcer Bleeding [NCT02020603] | 151 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus Surgery [NCT05867342] | Phase 4 | 40 participants (Actual) | Interventional | 2017-05-12 | Completed | ||
| The Effect of Oral Midodrine Versus Oral Desmopressin Acetate Use for Liberation From IV Noradrenaline in Intensive Care Unit Patients Recovering From Spinal Shock . [NCT04586790] | Phase 2 | 90 participants (Anticipated) | Interventional | 2020-10-15 | Recruiting | ||
| Comparison Between Effect of Adrenaline and Without Adrenaline in Tumescent Solutions on Bleeding Control of Skin Graft Donor Site. [NCT04590638] | 56 participants (Actual) | Interventional | 2020-10-17 | Completed | |||
| A Randomised, Open Label Study to Compare the Efficacy of Nor Adrenaline and Terlipressin vs Step up Terlipressin Therapy in Hepatorenal Syndrome [NCT01649037] | 0 participants (Actual) | Interventional | 2012-08-31 | Withdrawn(stopped due to lack of funds) | |||
| Topical Adrenaline Versus Warm Saline Solution for Minimizing Intraperitoneal Bleeding During Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS): A Randomized Controlled Study [NCT06030479] | 84 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | |||
| Prophylactic Racemic Epinephrine for the Prevention of Dysphagia in Patients Undergoing Anterior Cervical Discectomy and Fusion: A Randomized Control Trial [NCT02724761] | 90 participants (Anticipated) | Interventional | 2016-09-30 | Not yet recruiting | |||
| A Prospective Randomized Case Series Comparison on the Clinical Efficacy of Exparel Local Anesthetic in Total Knee Arthroplasty Patients [NCT02765815] | Phase 4 | 0 participants (Actual) | Interventional | 2016-02-29 | Withdrawn(stopped due to competing protocol) | ||
| An Parallel Control Clinical Trail on Effects of Adrenal Artery Ablation and Adrenalectomy in Patients With Primary Aldosteronism [NCT04269928] | 60 participants (Anticipated) | Interventional | 2016-01-19 | Recruiting | |||
| Pectoral Nerve (PECS) Block for Cardiac Implantable Electronic Devices (CIED) Implantation Surgery [NCT04577690] | Phase 4 | 48 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting | ||
| Assessment and Evaluation of Pharmacokinetic Profile of E004 in Healthy Adults (A Randomized, Evaluator-Blind, Single-Dose, Two Arm, Crossover, PK Study in Healthy Volunteers) [NCT01737892] | Phase 1/Phase 2 | 21 participants (Actual) | Interventional | 2012-11-30 | Terminated(stopped due to unable to validate analytical method) | ||
| Fluid Management in Patients Undergoing Cardiac Surgery - Effects of an Acetate Versus Lactate Buffered Balanced Infusion Solution on Hemodynamic Stability, a Randomized Controlled Double-blind Trial [NCT02895659] | Phase 4 | 150 participants (Actual) | Interventional | 2016-12-01 | Completed | ||
| Efficacy of Intracoronary Adrenaline and Its Comparison With Intracoronary Adenosine in the Treatment of No-Reflow in Normotensive Patients With Acute Coronary Syndrome [NCT04699110] | Phase 4 | 201 participants (Actual) | Interventional | 2021-01-01 | Completed | ||
| Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59) [NCT00591643] | Phase 1 | 93 participants (Actual) | Interventional | 1977-07-31 | Completed | ||
| Comparative Effect of Palatal Injection on Pain Perception in Pediatric Patient [NCT06025825] | 96 participants (Anticipated) | Observational [Patient Registry] | 2023-05-02 | Recruiting | |||
| Prophylactic Tranexamic Acid Versus Adrenaline for Bleeding Prevention During Flexible Bronchoscopy: a Double Blind, Randomized Controlled Trial [NCT06145191] | 840 participants (Anticipated) | Interventional | 2023-12-18 | Recruiting | |||
| A Randomized Controlled Trial Comparing Epinephrine and Dexamethasone to Placebo in the Treatment of Infants With Bronchiolitis [NCT03567473] | Phase 3 | 864 participants (Anticipated) | Interventional | 2018-12-13 | Recruiting | ||
| Hemodynamics and Extravascular Lung Water in Acute Lung Injury: A Prospective Randomized Controlled Multicentered Trial of Goal Directed Treatment of EVLW Versus Standard Management for the Treatment of Acute Lung Injury [NCT00624650] | Phase 2 | 33 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Effect of Dexmedetomidine as Adjuvant to Ropivacaine for Brachial Plexus Block [NCT05767827] | 40 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | |||
| Comparison of Infraclavicular and Supraclavicular Block Approaches in Ultrasound Guided Brachial Plexus Block [NCT04784104] | Phase 4 | 70 participants (Anticipated) | Interventional | 2021-03-05 | Not yet recruiting | ||
| Can the Risk of RD and Hypoglycemia in Children Born at Elective CS be Reduced by Injection of Adrenaline [NCT00322660] | 270 participants (Actual) | Interventional | 2006-06-30 | Completed | |||
| The Effect of Intraoperative Low Dose Adrenaline on Bleeding in Total Hip Arthroplasty - a Randomized Placebo-controlled Trial [NCT01708642] | Phase 3 | 106 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| Parameters in Fractional Laser Assisted Delivery of Topical Anesthetics: Role of Anesthetic and Application Time [NCT03279757] | Phase 4 | 15 participants (Actual) | Interventional | 2016-10-01 | Completed | ||
| Phase 3 Study of Adrenaline and Milrinone in Patients With Myocardial Dysfunction [NCT00446017] | Phase 3 | 60 participants | Interventional | 2003-06-30 | Completed | ||
| Randomized Controlled Trial Examining the Effect of Subcutaneous Xylocaine 2% on the Incidence of Vasovagal Reactions and Pain Intensity During Femoral Artery Sheath Removal. [NCT00465439] | 78 participants (Actual) | Interventional | 2007-05-31 | Completed | |||
| Effect of Adrenaline Concentration in Tumescence Solution on Intraoperative Hemodynamics of Liposuction Patients: A Randomized Controlled Trial [NCT05822765] | Phase 3 | 40 participants (Actual) | Interventional | 2023-05-01 | Completed | ||
| Selective Trunk Block Versus Hybrid Interscalene-Supraclavicular Brachial Plexus Block for Anaesthesia of the Entire Upper Extremity: A Randomized Double-Blind Controlled Trial [NCT04908371] | 0 participants (Actual) | Interventional | 2022-12-31 | Withdrawn(stopped due to Published data indicated Selective Trunk Block is a better choice) | |||
| Intracoronary Administration of Epinephrine and Verapamil in the Refractory No-reflow Phenomenon in Patients With Acute Myocardial Infarction: The EPIVER Randomized Controlled Trial [NCT04573751] | 104 participants (Actual) | Interventional | 2020-12-30 | Active, not recruiting | |||
| Evaluating the Effectiveness of Local Multimodal Injection in Controlling Pain, Limiting Complications, and Reducing Cost as Compared to Regional Anesthesia for Treating Rotational Ankle Fractures. [NCT05019638] | Early Phase 1 | 200 participants (Anticipated) | Interventional | 2021-05-15 | Enrolling by invitation | ||
| A Comparative Study for Evaluation of the Analgesic Profile of Ultrasound-Guided Modified Pectoral Nerves Block Versus Serratus Plane Block in Major Breast Cancer Surgery [NCT02946294] | Phase 2 | 90 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Endoscopic Ultrasound-guided Radiofrequency Ablation as a Novel Treatment Option Compared With Adrenalectomy in Left-sided Primary Aldosteronism [NCT05368090] | 40 participants (Anticipated) | Interventional | 2022-06-03 | Recruiting | |||
| A Prospective Randomized Comparison of the Effects of Lidocaine and Levobupivacaine on Block Dynamics After a Subparaneural Popliteal Sciatic Nerve Block [NCT04397484] | Phase 4 | 40 participants (Anticipated) | Interventional | 2023-09-20 | Recruiting | ||
| Articaine Efficacy and Safety for 3 Years Old Children: A Clinical Randomized Control Trial [NCT05839548] | Phase 3 | 200 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| A Randomised, Double-blinded Multi-centre Trial Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest at the Emergency Department. (Preadmission Intravenous Vasopressin, Adrenaline Outcome Trial: PIVOT vII) [NCT00358579] | Phase 3 | 727 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| Analgesic Efficacy of a Combination of Fentanyl and Lidocaine for Maxillary Infiltration in Teeth With Irreversible Pulpitis [NCT01794533] | Phase 2 | 64 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Surgical Treatment of Carpal Tunnel Syndrome: Local Anesthesia With Epinephrine x Intravenous Regional Anesthesia. Randomized Clinical Trial. [NCT02986347] | 78 participants (Actual) | Interventional | 2017-05-27 | Completed | |||
| Effect of Lidocaine and Adrenaline Soaked Gauze Versus Normal Saline Soaked at Skin Graft Donor Site of Thigh: A Randomized Control Trial [NCT04344483] | 60 participants (Actual) | Interventional | 2019-12-10 | Completed | |||
| Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery: Cocaine Versus Adrenaline [NCT01706952] | Phase 4 | 45 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Perioperative Analgesia for Total Hip Arthroplasty: Lumbar Plexus Block Using Shamrock Technique Versus Fascia Iliaca Block [NCT04670497] | 70 participants (Actual) | Interventional | 2018-07-01 | Completed | |||
| The Effect of Intranasal Irrigation With Adrenaline Solution on Intraoperative Visualization and Bleeding During Functional Endoscopic Sinus Surgery [NCT04551703] | Phase 1 | 60 participants (Actual) | Interventional | 2016-07-01 | Completed | ||
| Comparison of 2 Application Techniques for LET (Lidocaine 4%; Epinephrine 0.1%; Tetracaine 0.5%) Gel Used Prior to Simple Laceration Repair [NCT04536493] | Phase 4 | 48 participants (Actual) | Interventional | 2019-06-19 | Completed | ||
| Postoperative Analgesia After Total Hip Arthroplasty. A Comparison of Continuous Epidural Infusion and Wound Infiltration With Intraarticular Bolus Injection. [NCT00289419] | Phase 4 | 80 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Low Dose Adrenaline, Promethazine, & Hydrocortisone (Alone and in Combination) to Prevent Acute Adverse Reactions to Antivenom in People Bitten by Snakes: Randomised, Double Blind, Placebo-Controlled Trial [NCT00270777] | Phase 4 | 1,000 participants (Anticipated) | Interventional | 2005-03-31 | Completed | ||
| Safety and Efficacy of Cocktail Periarticular Injection for Pain Management in Simultaneous Bilateral Total Knee Arthroplasty- A Prospective, Randomized Trial [NCT02270437] | Phase 4 | 55 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| Does the Addition of Epinephrine Increase the Duration of Intrathecal Hyperbaric Bupivacaine for Repeat Cesarean Section? [NCT02369510] | Phase 4 | 68 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Buffered vs Unbuffered Local Anesthesia Using Lidocaine, Carbocaine, and Articaine in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis [NCT06047366] | Phase 4 | 60 participants (Anticipated) | Interventional | 2023-12-05 | Recruiting | ||
| The Effect and Safety of Low Dose Nebulized Epinephrine in the Treatment of Croup [NCT01664507] | Phase 4 | 84 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| "Hemodynamic and Electrocardiographic Effects of Hyaluronidase Associated With Local Anaesthetics: a Double-blind Split-mouth Controlled Trial." [NCT01719978] | Phase 4 | 20 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Sciatic Nerve Block for Ankle/Foot Surgeries. A Comparison Between a Premixed Solution of Lidocaine Plus Bupivacaine and Consecutive Infiltration of Lidocaine and Bupivacaine. A Double Blinded Randomised Controlled Prospective Study [NCT01756443] | Phase 4 | 40 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Onset and Duration of Effect of Lidocaine, Bupivacaine, and Lidocaine/Bupivacaine Mixture With Epinephrine. [NCT01243112] | Phase 4 | 25 participants (Actual) | Interventional | 2010-05-31 | Completed | ||
| A Prospective, Multicenter Study to Evaluate Effectiveness and Safety of Tymbion Iontophoresis and Tympanostomy Tube Placement Using the Tula Iontophoresis and Tube Delivery Systems for Adults in an Office Setting [NCT03119181] | Phase 2 | 40 participants (Actual) | Interventional | 2017-04-27 | Completed | ||
| A Comparison of Tumescence in Breast Reduction Surgery [NCT01602692] | Phase 4 | 40 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection in 70 Patients Undergoing Total Knee Arthroplasty Without Femoral Nerve Block: a Double-blinded, Randomized Clinical Trial [NCT02299349] | 70 participants (Actual) | Interventional | 2013-08-31 | Completed | |||
| Postoperative Analgesia After Total Knee Arthroplasty. A Comparison of Continuous Epidural Infusion and Wound Infiltration With Continuous Intraarticular Infusion [NCT00421967] | Phase 4 | 80 participants (Actual) | Interventional | 2007-01-31 | Terminated(stopped due to Interim analysis) | ||
| Tranexamic Acid Versus Adrenaline for Controlling Iatrogenic Endobronchial Bleeding: a Double Blind, Randomized Controlled Trial [NCT04771923] | 130 participants (Actual) | Interventional | 2021-02-22 | Completed | |||
| Epinephrine Inhalation Aerosol USP, an HFA-MDI CLINICAL STUDY-B2 FOR ASSESSMENT OF PHARMACOKINETICS (A Randomized, Evaluator-Blind, Single-Dose, Two Arm, Crossover, PK Study in Healthy Volunteers) [NCT01188577] | Phase 1/Phase 2 | 23 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Mild to Moderately Severe Bronchiolitis - A Double Blind Randomized Controlled Trial. [NCT01276821] | Phase 4 | 100 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| A Randomized Controlled Trial of a Full and a Fractional Ablative Carbon Dioxide Laser as Pretreatment for Photodynamic Therapy in the Management of Superficial Non Melanoma Skin Cancer [NCT03012009] | 16 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| Pharmacokinetics and Pharmacodynamics for Levobupivacaine With and Without Epinephrine After Ultrasound Guided Erector Spinae Plane Block [NCT04799184] | Phase 4 | 38 participants (Anticipated) | Interventional | 2019-04-03 | Recruiting | ||
| Comparison of Adductor Canal Block Combined With IPACK Block and Adductor Canal Block Combined With PCI for Postoperative Analgesia and Function Recovery Following Total Knee Arthroplasty:A Prospective, Double-Blind, Randomized Controlled Study [NCT05943080] | 159 participants (Anticipated) | Interventional | 2023-06-01 | Active, not recruiting | |||
| Comparison the Effect of Lidocaine (With Epinephrine) With and Without Sufentanil on the Rate of Anesthesia of Intra-ligamentary Injection in Teeth With Irreversible Pulpitis [NCT01572116] | Phase 2 | 60 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Comparison of Plasma Concentrations of Levobupivacaine With and Without Epinephrine for Transversus Abdominis Plane Block Under Ultrasound. [NCT01596998] | Phase 4 | 11 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Fertility and Pregnancy in Patients With Classic Congenital Adrenal Hyperplasia [NCT06153043] | 55 participants (Anticipated) | Observational | 2023-12-31 | Not yet recruiting | |||
| Anesthetic Efficacy of 4% Buffered Lidocaine in Emergency Patients With Facial Swelling. [NCT01981772] | 88 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery [NCT05767749] | Phase 4 | 75 participants (Actual) | Interventional | 2023-03-14 | Completed | ||
| A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Technique Versus Laparoscopic Transversus Abdominis Plane Nerve Block Technique Versus No Block on Postoperative Opioid Consumption After Major Colorectal Surgery [NCT02538679] | 127 participants (Actual) | Interventional | 2015-08-07 | Completed | |||
| An Open-label, Cohort Study on Effects and Long-term Prognosis of Adrenal Artery Ablation and Spironolactone in Patients With Primary Aldosteronism [NCT04409431] | 60 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting | |||
| Efficacy of External Nasal Nerve Block on Postoperative Agitation Following Nasal Surgeries Under General Anesthesia. Randomized, Controlled Trial [NCT03069027] | 100 participants (Actual) | Interventional | 2016-08-15 | Completed | |||
| Early Ultrasound-guided Nerve Block for Painful Hand Injuries in the Emergency Department [NCT03195413] | 15 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Adductor Canal Block and Functional Recovery After Total Knee Arthroplasty. A Double-Blind, Randomized Controlled Trial [NCT02411149] | Phase 4 | 200 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| Comparison of Two Different Concentrations of Local Anesthetic in Patient Reported Pain in Oculoplastic Surgery [NCT06121141] | Phase 4 | 30 participants (Anticipated) | Interventional | 2023-08-07 | Enrolling by invitation | ||
| Clinical Effectiveness of Erector Spinae Plane Block in Peri-operative Analgesia for Laparoscopic Kidney Procedures [NCT03874091] | 62 participants (Actual) | Interventional | 2019-01-15 | Completed | |||
| Role of Adrenaline in the Inflammatory Response in People With Diabetes Mellitus Type 1, and Healthy Individuals [NCT05990933] | 30 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | |||
| Evaluation of Cardiac Arrhythmias in Hand Surgery Using Local Anesthesia With Adrenaline [NCT04029610] | 110 participants (Actual) | Interventional | 2018-08-14 | Completed | |||
| Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagers: Does Dose Matter? [NCT03366298] | Phase 4 | 12 participants (Actual) | Interventional | 2017-11-24 | Completed | ||
| The Effects of Injection Site Cooling and Solution Buffering on Perceived Pain During Local Anesthesia Administration [NCT04991597] | 0 participants (Actual) | Interventional | 2022-01-01 | Withdrawn(stopped due to Shift in research focus) | |||
| Phase 3 Study of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy [NCT02112370] | Phase 3 | 148 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Subcutaneous Tranexamic Acid in Nasal Mohs Local Flap Reconstruction: Perioperative Bleeding, Edema, and Ecchymosis [NCT06057675] | Phase 2 | 100 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| The Effectiveness of Automated Soft Tissue Vibration in Reducing Pain and Accelerating Action of Intraoral Local Anesthesia Injections in Adult Dental Patients. A Randomized Crossover Clinical Trial. [NCT03839134] | 166 participants (Actual) | Interventional | 2019-03-20 | Completed | |||
| The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper Gastrointestinal Bleeding: A Randomized Controlled Trial [NCT04979273] | 66 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | |||
| Fast-track Rehabilitation Protocol for Total Knee Arthroplasty: A Randomized Controlled Trial Comparing Local Infiltration Analgesia With Femoral Nerve Block [NCT01966263] | Phase 4 | 80 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Alkalinization of Adrenalized Lidocaine in Extending Epidural Analgesia for Extremely Urgent Cesarean Section During Labor: a Randomized Controlled Trial. [NCT05313256] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2022-07-14 | Recruiting | ||
| The Use of Epinephrine Infusion for Prophylaxis Against Maternal Hypotension During Cesarean Delivery: a Randomized Controlled Dose-finding Trial [NCT05279703] | Phase 4 | 276 participants (Anticipated) | Interventional | 2022-03-21 | Recruiting | ||
| Comparison of Different Approaches for Supraclavicular Block and Their Effects on Diaphragm Muscle Function Evaluated With Diaphragm Thickening Fraction [NCT04756050] | Phase 4 | 90 participants (Actual) | Interventional | 2021-02-16 | Completed | ||
| Risk Factors and Postoperative Complications of Reperfusion Syndrome and Vasoplegic Syndrome in Patients With Vasoactive Support During Liver Transplant Surgery [NCT05658120] | 246 participants (Actual) | Observational | 2022-12-13 | Completed | |||
| Multicenter, Randomized, Split-mouth Study to Evaluate the Acceptance and Preference of Lidocaine Gel Compared to Injection Anesthesia After Non Surgical Periodontal Treatment [NCT03354312] | Phase 4 | 94 participants (Actual) | Interventional | 2017-12-05 | Completed | ||
| A Prospective Randomized, Double-blind Study of the Anesthetic Efficacy of Buffered Articaine as a Primary Buccal Infiltration of the Mandibular First Molar. [NCT01862614] | Phase 4 | 80 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial (EPI Dose) [NCT05327556] | Phase 2 | 86 participants (Anticipated) | Interventional | 2023-02-08 | Enrolling by invitation | ||
| Evaluation of New Methods for Prediction of Fetal Lung Maturity in Diabetic Mothers [NCT03159234] | 54 participants (Actual) | Interventional | 2016-04-30 | Completed | |||
| CLINICAL STUDY-B3 FOR ASSESSMENT OF PHARMACOKINETICS, A Randomized, Evaluator-Blind, Single-Dose, Three Arm, Crossover,PK Study in Healthy Volunteers [NCT01255709] | Phase 2 | 24 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Incident and Extent of Pulse Alteration During Administration of Various Modes of Local Anesthesia in Children During Routine Dental Treatment [NCT02328729] | 300 participants (Anticipated) | Observational | 2015-01-31 | Not yet recruiting | |||
| Articaine Success in Pulpectomy of Primary Molars With Irreversible Pulpitis in Children Under Four Years: a Randomized Controlled Trial [NCT05944341] | 164 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Articaine 4% Efficacy and Safety in Extraction and Pulpotomy of Primary Molars of Children Below the Age of Four Years. [NCT05101785] | 292 participants (Anticipated) | Interventional | 2021-11-01 | Not yet recruiting | |||
| Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery: an Outcome Study of Patients' Pain Perception. [NCT02315573] | 61 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| Complication in Laparoscopic Renal and Adrenal Surgery (CLARAS): an International Multicenter Study [NCT05322265] | 350 participants (Anticipated) | Observational | 2017-04-01 | Recruiting | |||
| An Open-label, Prospective, Controlled Clinical Trial on Effects and Safety of Adrenal Artery Ablation (Triple A) for Primary Aldosteronism [NCT03398785] | Phase 3 | 66 participants (Actual) | Interventional | 2017-10-01 | Completed | ||
| Levosimendan Versus Adrenaline in Patients With Low Left Ventricular Function Undergoing Elective On-Pump Coronary Artery Bypass Graft Surgery. A Randomized Controlled Study [NCT05222256] | 52 participants (Anticipated) | Interventional | 2022-03-31 | Not yet recruiting | |||
| Comparison of the Effect of Vasopressin, Steroid, and Epinephrine Treatment in Patients With Out-of-hospital Cardiac Arrest: Multi-center, Double Blind, Randomized, Placebo-controlled Study [NCT03317197] | Phase 4 | 834 participants (Anticipated) | Interventional | 2018-01-01 | Recruiting | ||
| A Randomized Clinical Trial to Compare the Addition of Epinephrine (no Epinephrine, 100mcg, and 200mcg) to the Standard Dose of Hyperbaric Bupivacaine 12mg, Fentanyl 20mcg and Morphine 150mcg in Scheduled C-sections. [NCT03335293] | Phase 4 | 0 participants (Actual) | Interventional | 2019-10-31 | Withdrawn(stopped due to Due to FDA constraints on the off label use of the medications we will not be able to conduct this evaluation.) | ||
| The Impact of Retropubic Lidocaine vs Saline on Postoperative Urinary Retention Following Midurethral Sling: A Randomized Placebo Controlled Trial [NCT03913845] | Phase 4 | 150 participants (Anticipated) | Interventional | 2019-11-25 | Recruiting | ||
| Adrenal Artery Ablation Treats Primary Aldosteronism With Resistant Hypertension (AAA-RHT) [NCT04345198] | 36 participants (Actual) | Interventional | 2017-10-01 | Completed | |||
| Impact of intRacoronary adrEnaline on Myocardial reperfuSion in STEMI paTients With Persistent Impaired cORonary Flow After pErcutaneous Coronary Intervention: the RESTORE-SIRIO Randomized Controlled Trial [NCT02405130] | 0 participants (Actual) | Interventional | 2015-04-30 | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||