Page last updated: 2024-12-06

hexafluorosilicate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Hexafluorosilicates are salts containing the hexafluorosilicate anion, [SiF6]2-. They are typically synthesized by reacting hydrofluoric acid with silicon dioxide or other silicon-containing compounds. Hexafluorosilicates are used in a variety of applications, including as a source of fluoride ions for dental health, as a component in some types of glass and ceramics, and as a pesticide. They are also studied for their potential applications in other fields, such as in the production of solar cells and in the development of new materials. Hexafluorosilicates are generally considered to be relatively safe compounds, although they can be irritating to the skin, eyes, and respiratory system. '
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hexafluorosilicate: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID28117
CHEBI ID37189
MeSH IDM0046040

Synonyms (20)

Synonym
silicate(2-), hexafluoro-
fluosilicate
un2856
silicofluoride
CHEBI:37189 ,
sif6(2-)
[sif6](2-)
hexafluoridosilicate(iv)
hexafluoridosilicate(2-)
17084-08-1
hexafluorosilicate(2-) ion
silicon hexafluoride ion
hexafluorosilicate
hexafluorosilicate(2-)
hexafluorosilicon(2-)
fluorosilicates, n.o.s. [un2856] [poison]
fluorosilicates, n.o.s.
DTXSID8047214
OHORFAFFMDIQRR-UHFFFAOYSA-N
Q27117065

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The results of this study suggest that the new rinse may provide a greater cariostatic effect at the same fluoride dosage than does a NaF rinse."( In vivo fluoride concentrations measured for two hours after a NaF or a novel two-solution rinse.
Carey, CM; Chow, LC; Mao, Y; Takagi, S; Vogel, GL, 1992
)
0.28
" Increasing concentrations of NaF (5, 10, 15 ppm F), Na-Silicofluoride, or NaMFP showed similar caries-inhibiting effects without remarkable influence of the fluoride dosage used."( The effects of non-fluoridated and fluoridated milk on experimental caries in rats.
Grosser, W; Kneist, S; Stösser, L, 1995
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
silicon coordination entity
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency11.42390.005612.367736.1254AID624032
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.62280.251215.843239.8107AID504327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (61)

TimeframeStudies, This Drug (%)All Drugs %
pre-199014 (22.95)18.7374
1990's11 (18.03)18.2507
2000's14 (22.95)29.6817
2010's22 (36.07)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 51.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index51.33 (24.57)
Research Supply Index4.22 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index79.69 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (51.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (4.69%)5.53%
Reviews1 (1.56%)6.00%
Case Studies4 (6.25%)4.05%
Observational0 (0.00%)0.25%
Other56 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]