dantrolene has been researched along with Fasciculation in 5 studies
Dantrolene: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
dantrolene : The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.
Fasciculation: Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations may be visualized as a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls." | 5.04 | Dantrolene and suxamethonium. The effect of pre-operative dantrolene on the action of suxamethonium. ( Collier, CB, 1979) |
| "Total fasciculation score was not significantly reduced by the dantrolene pretreatment." | 2.66 | Oral dantrolene prevents rise of myoglobin due to suxamethonium. ( Laurence, AS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muiños, PA | 1 |
| Ortells, MA | 1 |
| Sánchez, G | 1 |
| Carrasco, MS | 1 |
| Mizogami, M | 1 |
| Fujibayashi, T | 1 |
| Goto, Y | 1 |
| Tiguert, R | 1 |
| Lewis, RA | 1 |
| Gheiler, EL | 1 |
| Tefilli, MV | 1 |
| Gudziak, MR | 1 |
| Collier, CB | 1 |
| Laurence, AS | 1 |
2 trials available for dantrolene and Fasciculation
| Article | Year |
|---|---|
Dantrolene and suxamethonium. The effect of pre-operative dantrolene on the action of suxamethonium.
Topics: Adult; Clinical Trials as Topic; Dantrolene; Drug Interactions; Fasciculation; Female; Humans; Hydan | 1979 |
Oral dantrolene prevents rise of myoglobin due to suxamethonium.
Topics: Administration, Oral; Adolescent; Adult; Creatine Kinase; Dantrolene; Drug Evaluation; Fasciculation | 1985 |
3 other studies available for dantrolene and Fasciculation
| Article | Year |
|---|---|
[A case of malignant hyperthermia without hyperthermia].
Topics: Adolescent; Carbon Dioxide; Creatine Kinase; Dantrolene; Drug Eruptions; Fasciculation; Female; Huma | 1995 |
Succinylcholine-induced fasciculations in denervated rat muscles as measured using 31P-NMR spectroscopy: the effect of pretreatment with dantrolene or vecuronium.
Topics: Animals; Calcium; Dantrolene; Fasciculation; Magnetic Resonance Spectroscopy; Male; Muscle Denervati | 1998 |
Case report: acute urinary retention secondary to Isaacs' syndrome.
Topics: Acute Disease; Adult; Carbamazepine; Dantrolene; Fasciculation; Humans; Male; Plasmapheresis; Urethr | 1999 |