donepezil has been researched along with Fasciculation in 2 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Fasciculation: Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations may be visualized as a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Muscle fasciculation appeared only after donepezil with a dose-dependent incidence and intensity." | 1.32 | Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats. ( Liang, YQ; Tang, XC, 2004) |
| "When mild to moderate fasciculation was evoked, donepezil and E2030 elicited more than nine yawns over 30 min, while the other cholinesterase inhibitors elicited approximately five yawns at most during this period." | 1.31 | Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats. ( Kosasa, T; Kuriya, Y; Ogura, H; Yamanishi, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, YQ | 1 |
| Tang, XC | 1 |
| Ogura, H | 1 |
| Kosasa, T | 1 |
| Kuriya, Y | 1 |
| Yamanishi, Y | 1 |
2 other studies available for donepezil and Fasciculation
| Article | Year |
|---|---|
Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain Chemistry; Carbama | 2004 |
Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats.
Topics: Acetylcholinesterase; Animals; Benzazepines; Benzoxazines; Butyrylcholinesterase; Cholinesterase Inh | 2001 |