Page last updated: 2024-10-26

edrophonium and Fasciculation

edrophonium has been researched along with Fasciculation in 4 studies

Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.

Fasciculation: Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations may be visualized as a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)

Research Excerpts

ExcerptRelevanceReference
"In addition, muscles with frequent fasciculations showed a larger decrement than the ones with rare fasciculation."1.26Amyotrophic lateral sclerosis. Impairment of neuromuscular transmission. ( Denys, EH; Norris, FH, 1979)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
OSSERMAN, KE1
KAPLAN, LI1
Denys, EH1
Norris, FH1
Okamoto, M1
Walewski, JL1
Artusio, JF1
Riker, WF1
Uebayashi, Y1
Yoshida, S1
Yase, Y1
Bessho, H1

Other Studies

4 other studies available for edrophonium and Fasciculation

ArticleYear
Rapid diagnostic test for myasthenia gravis: increased muscle strength, without fasciculations, after intravenous administration of edrophonium (tensilon) chloride.
    Journal of the American Medical Association, 1952, Sep-27, Volume: 150, Issue:4

    Topics: Administration, Intravenous; Chlorides; Curare; Diagnostic Tests, Routine; Edrophonium; Fasciculatio

1952
Amyotrophic lateral sclerosis. Impairment of neuromuscular transmission.
    Archives of neurology, 1979, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Cold Temperature; Edrophonium; Fasciculation

1979
Neuromuscular pharmacology in rat neonates: development of responsiveness to prototypic blocking and reversal drugs.
    Anesthesia and analgesia, 1992, Volume: 75, Issue:3

    Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cholinesterase Inhibitors; Curare; Dose-Response

1992
[Spontaneous discharges in motor neuron disease: evocation by edrophonium and degenerative process].
    Rinsho shinkeigaku = Clinical neurology, 1987, Volume: 27, Issue:4

    Topics: Adult; Aged; Edrophonium; Electromyography; Fasciculation; Female; Humans; Male; Middle Aged; Motor

1987