calpain and Mucopolysaccharidosis-III

calpain has been researched along with Mucopolysaccharidosis-III* in 1 studies

Other Studies

1 other study(ies) available for calpain and Mucopolysaccharidosis-III

Article	Year
Abnormal expression of truncated CRMP-1 protein in the brain cortex of MPSIIIB mice. Molecular genetics and metabolism, 2008, Volume: 94, Issue:1 Mucopolysaccharidosis IIIB is a lysosomal disease characterized by a severe neurological deterioration, the pathophysiological mechanisms of which are poorly understood. Recently FGF pathway was shown to be altered leading us to explore a downstream target involved in brain development: the collapsin response mediator protein-1 (CRMP-1). CRMP-1 transcript level was normal but a cleavage of CRMP-1 was observed with an abnormal expression of the truncated form until adult age. This truncated CRMP-1 protein could play a role in post-natal cortex maturation and be involved in neuronal alterations occurring in lysosomal diseases. Topics: Animals; Calpain; Cerebral Cortex; Fibroblast Growth Factors; Gene Expression; Male; Mice; Mice, Inbred C57BL; Mucopolysaccharidosis III; Nerve Tissue Proteins; Phosphoproteins	2008

Article

Year

Abnormal expression of truncated CRMP-1 protein in the brain cortex of MPSIIIB mice.

Molecular genetics and metabolism, 2008, Volume: 94, Issue:1

Mucopolysaccharidosis IIIB is a lysosomal disease characterized by a severe neurological deterioration, the pathophysiological mechanisms of which are poorly understood. Recently FGF pathway was shown to be altered leading us to explore a downstream target involved in brain development: the collapsin response mediator protein-1 (CRMP-1). CRMP-1 transcript level was normal but a cleavage of CRMP-1 was observed with an abnormal expression of the truncated form until adult age. This truncated CRMP-1 protein could play a role in post-natal cortex maturation and be involved in neuronal alterations occurring in lysosomal diseases.

Topics: Animals; Calpain; Cerebral Cortex; Fibroblast Growth Factors; Gene Expression; Male; Mice; Mice, Inbred C57BL; Mucopolysaccharidosis III; Nerve Tissue Proteins; Phosphoproteins

2008