4-methylumbelliferyl 2-acetamido-2-deoxy-beta-d-glucopyranoside profile

4-methylumbelliferyl 2-acetamido-2-deoxy-beta-d-glucopyranoside (MUG) is a fluorogenic substrate for the enzyme N-acetyl-beta-D-glucosaminidase (NAGase). It is commonly used in research and diagnostics due to its sensitivity and specificity for NAGase activity. MUG is hydrolyzed by NAGase to release the highly fluorescent compound 4-methylumbelliferone. This reaction can be monitored using a fluorometer, allowing for the quantification of NAGase activity. MUG is often used in research to study the role of NAGase in various physiological and pathological processes, such as inflammation, cancer, and infection. It is also used in diagnostic assays for the detection and monitoring of diseases associated with NAGase activity, such as lysosomal storage disorders.'

4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside: RN given refers to (beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	121923
SCHEMBL ID	18132142
MeSH ID	M0084200

Synonym
n-[(3r,4r,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]acetamide
einecs 253-333-0
4-methylumbelliferyl 2-acetamido-2-deoxy-beta-d-glucopyranoside
4-methylumbelliferyl-n-acetyl-beta-glucosamine
7-((2-acetamido-2-deoxy-beta-d-glucopyranosyl)oxy)-4-methyl-2h-1-benzopyran-2-one
4-methylumbelliferyl-n-acetylglucosaminide
2h-1-benzopyran-2-one, 7-((2-(acetylamino)-2-deoxy-beta-d-glucopyranosyl)oxy)-4-methyl-
SCHEMBL18132142
DTXSID80926895
4-methyl-2-oxo-2h-1-benzopyran-7-yl 2-deoxy-2-[(1-hydroxyethylidene)amino]hexopyranoside
13077-96-8

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (33.33)	18.7374
1990's	11 (36.67)	18.2507
2000's	6 (20.00)	29.6817
2010's	3 (10.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (6.45%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (93.55%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
lactose Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.. lactose : A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.. beta-lactose : The beta-anomer of lactose.	2.02	1	lactose
asparagine Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). asparagine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group.	2.02	1	amino acid zwitterion; asparagine; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	4.72	30	N-acetyl-D-glucosamine	epitope
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.02	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.36	2	D-glucopyranose	epitope; mouse metabolite
4-methylumbelliferyl phosphate [no description available]	1.97	1
4-methylumbelliferyl sulfate 4-methylumbelliferyl sulfate: RN given refers to parent cpd. 4-methylumbelliferone sulfate : A member of the class of coumarins that is umbelliferone sulfate which carries a methyl group at position 4. It is a metabolite of 4-methylumbelliferone.	1.97	1	aryl sulfate; coumarins	human xenobiotic metabolite
4-methylumbelliferyl-galactopyranoside 4-methylumbelliferyl-galactopyranoside: fluorogenic substrate; RN given refers to (beta-D)-isomer. 4-methylumbelliferyl beta-D-galactoside : A beta-D-galactoside having a 4-methylumbelliferyl substituent at the anomeric position.	1.95	1	beta-D-galactoside; coumarins; monosaccharide derivative	chromogenic compound
chitotriose chitotriose : An amino trisaccharide comprising of three 2-amino-2-deoxy-D-glucopyranose units joined by beta-(1->4) linkages.	2.01	1
4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-glucopyranoside 4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-glucopyranoside: used for diagnosis of B variants of GM2 gangliosidosis	2.9	4
4-methylumbelliferyl-n,n-diacetylchitobioside [no description available]	2.01	1
glucosamine D-glucosamine : An amino sugar whose structure comprises D-glucose having an amino substituent at position 2.. 2-amino-2-deoxy-D-glucopyranose : A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.	3.91	13	D-glucosamine	Escherichia coli metabolite; geroprotector; mouse metabolite
4-methylumbelliferyl glucoside 4-methylumbelliferyl glucoside: RN given refers to (beta)-isomer. 4-methylumbelliferyl beta-D-glucoside : A beta-D-glucoside having a 4-methylumbelliferyl substituent at the anomeric position.	1.95	1	beta-D-glucoside; coumarins; monosaccharide derivative	chromogenic compound
hymecromone Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.	4.72	30	hydroxycoumarin	antineoplastic agent; hyaluronic acid synthesis inhibitor
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	1.97	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
g(m2) ganglioside G(M2) Ganglioside: A glycosphingolipid that accumulates due to a deficiency of hexosaminidase A or B (BETA-N-ACETYLHEXOSAMINIDASES), or GM2 activator protein, resulting in GANGLIOSIDOSES, heredity metabolic disorders that include TAY-SACHS DISEASE and SANDHOFF DISEASE.. ganglioside GM2 (18:0) : A sialotriaosylceramide that is N-acetyl-beta-D-galactosaminyl-(1->4)-alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine in which the acyl group on the sphingosine nitrogen is octadecanoyl. A constituent of natural ganglioside GM2.	2.66	3	N-acetyl-beta-D-galactosaminyl-(1->4)-alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine; sialotriaosylceramide	antigen
chitosan [no description available]	2.01	1
hyaluronoglucosaminidase Hyaluronoglucosaminidase: An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.	1.98	1
orabase Orabase: used in therapy of oral mucosal ulcers	2.1	1

Condition	Relationship Strength	Studies
Amaurotic Familial Idiocy An outdated term for Tay-Sachs disease.	2.9	4
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.9	4
Tay-Sachs Disease An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased HEXOSAMINIDASE B but absence of hexosaminidase A) and is strongly associated with Ashkenazic Jewish ancestry.	2.9	4
Ganglioside Storage Diseases [description not available]	2.37	2
Gangliosidoses A group of autosomal recessive lysosomal storage disorders marked by the accumulation of GANGLIOSIDES. They are caused by impaired enzymes or defective cofactors required for normal ganglioside degradation in the LYSOSOMES. Gangliosidoses are classified by the specific ganglioside accumulated in the defective degradation pathway.	2.37	2
Acid beta-Glucosidase Deficiency [description not available]	1.95	1
Gaucher Disease An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.	1.95	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	1.98	1
Acetyl-CoA:alpha-Glucosaminide N-Acetyltransferase Deficiency [description not available]	2.67	3
Mucopolysaccharidosis III Mucopolysaccharidosis characterized by heparitin sulfate in the urine, progressive mental retardation, mild dwarfism, and other skeletal disorders. There are four clinically indistinguishable but biochemically distinct forms, each due to a deficiency of a different enzyme.	2.67	3
Uremia A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.	1.96	1
Mucopolysaccharidosis [description not available]	1.96	1
Mucopolysaccharidoses Group of lysosomal storage diseases each caused by an inherited deficiency of an enzyme involved in the degradation of glycosaminoglycans (mucopolysaccharides). The diseases are progressive and often display a wide spectrum of clinical severity within one enzyme deficiency.	1.96	1

4-methylumbelliferyl 2-acetamido-2-deoxy-beta-d-glucopyranoside

Description

Cross-References

Synonyms (11)

Research

Studies (30)

Market Indicators

Research Demand Index: 10.79

Study Types