suramin has been researched along with Mucopolysaccharidosis III in 1 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Mucopolysaccharidosis III: Mucopolysaccharidosis characterized by heparitin sulfate in the urine, progressive mental retardation, mild dwarfism, and other skeletal disorders. There are four clinically indistinguishable but biochemically distinct forms, each due to a deficiency of a different enzyme.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mucopolysaccharidosis type IIID (MPS IIID) is characterized by deficiency in lysosomal N-acetylglucosamine 6-sulfatase activity and the accumulation and excretion of heparan sulfates and N-acetylglucosamine 6-sulfate." | 1.31 | Metabolic studies of glycosphingolipid accumulation in mucopolysaccharidosis IIID. ( Bieberich, E; Jones, MZ; Liour, SS; Suzuki, M; Yu, RK, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liour, SS | 1 |
| Jones, MZ | 1 |
| Suzuki, M | 1 |
| Bieberich, E | 1 |
| Yu, RK | 1 |
1 other study available for suramin and Mucopolysaccharidosis III
| Article | Year |
|---|---|
Metabolic studies of glycosphingolipid accumulation in mucopolysaccharidosis IIID.
Topics: Age Factors; Animals; Brain; Glycosphingolipids; Goats; Lysosomes; Mice; Mucopolysaccharidosis III; | 2001 |