modafinil has been researched along with Sleepiness in 6 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Sleepiness: Compelling urge to sleep.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary outcome measure was the insomnia severity index (ISI), and secondary outcomes were the Epworth sleepiness scale, sleep restriction adherence scale (SRAS), and safety from baseline through to 12 weeks." | 7.30 | Armodafinil to reduce the sleepiness related side-effects of sleep restriction therapy being used to treat insomnia disorder: An open label clinical trial pilot study compared with historical controls. ( Bartlett, DJ; Espie, CA; Grunstein, RR; Jomaa, I; Judge, DJ; Kyle, SD; Marshall, NS; Miller, CB; Saini, B; Semsarian, CR; Wong, KKW; Yee, BJ, 2023) |
| "Modafinil (200-400 mg/d), sodium oxybate 9 g/d, and pitolisant up to 40 mg/d had similar efficacy in reducing excessive day time sleepiness." | 4.98 | Multiple treatment comparison in narcolepsy: a network meta-analysis. ( Falissard, B; Lehert, P, 2018) |
| "The primary outcome measure was the insomnia severity index (ISI), and secondary outcomes were the Epworth sleepiness scale, sleep restriction adherence scale (SRAS), and safety from baseline through to 12 weeks." | 3.30 | Armodafinil to reduce the sleepiness related side-effects of sleep restriction therapy being used to treat insomnia disorder: An open label clinical trial pilot study compared with historical controls. ( Bartlett, DJ; Espie, CA; Grunstein, RR; Jomaa, I; Judge, DJ; Kyle, SD; Marshall, NS; Miller, CB; Saini, B; Semsarian, CR; Wong, KKW; Yee, BJ, 2023) |
| "Excessive daytime sleepiness (EDS) is related to medical and social problems, including mental disorders, physical diseases, poor quality of life, and so forth." | 2.66 | Pharmacologic Management of Excessive Daytime Sleepiness. ( Nishino, S; Takenoshita, S, 2020) |
| "A 67-year-old woman with neuromyelitis optica spectrum disorder (NMOSD) developed severe somnolence." | 1.56 | Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder. ( Ando, M; Daida, K; Hattori, N; Hayashida, A; Kanbayashi, T; Noda, K; Ogaki, K; Okuma, Y; Yokoyama, K, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
| Authors | Studies |
|---|---|
| Nicholson, PJ | 1 |
| Judge, DJ | 1 |
| Miller, CB | 1 |
| Bartlett, DJ | 1 |
| Jomaa, I | 1 |
| Wong, KKW | 1 |
| Saini, B | 1 |
| Semsarian, CR | 1 |
| Espie, CA | 1 |
| Kyle, SD | 1 |
| Grunstein, RR | 1 |
| Yee, BJ | 1 |
| Marshall, NS | 1 |
| Wingelaar-Jagt, YQ | 2 |
| Bottenheft, C | 2 |
| Riedel, WJ | 2 |
| Ramaekers, JG | 2 |
| Daida, K | 1 |
| Ogaki, K | 1 |
| Hayashida, A | 1 |
| Ando, M | 1 |
| Yokoyama, K | 1 |
| Noda, K | 1 |
| Kanbayashi, T | 1 |
| Hattori, N | 1 |
| Okuma, Y | 1 |
| Takenoshita, S | 1 |
| Nishino, S | 1 |
| Lehert, P | 1 |
| Falissard, B | 1 |
2 reviews available for modafinil and Sleepiness
| Article | Year |
|---|---|
Pharmacologic Management of Excessive Daytime Sleepiness.
Topics: Central Nervous System Stimulants; Disorders of Excessive Somnolence; Humans; Idiopathic Hypersomnia | 2020 |
Multiple treatment comparison in narcolepsy: a network meta-analysis.
Topics: Adult; Cataplexy; Humans; Modafinil; Narcolepsy; Network Meta-Analysis; Odds Ratio; Piperidines; Ris | 2018 |
2 trials available for modafinil and Sleepiness
| Article | Year |
|---|---|
Armodafinil to reduce the sleepiness related side-effects of sleep restriction therapy being used to treat insomnia disorder: An open label clinical trial pilot study compared with historical controls.
Topics: Humans; Modafinil; Pilot Projects; Sleep Initiation and Maintenance Disorders; Sleepiness; Treatment | 2023 |
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum | 2023 |
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum | 2023 |
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum | 2023 |
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Fatigue; Hum | 2023 |
2 other studies available for modafinil and Sleepiness
| Article | Year |
|---|---|
Night work, sleepiness and modafinil.
Topics: Benzhydryl Compounds; Disorders of Excessive Somnolence; Humans; Modafinil; Sleep Disorders, Circadi | 2021 |
Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder.
Topics: Aged; Central Nervous System Stimulants; Female; Humans; Japan; Magnetic Resonance Imaging; Methylph | 2020 |