Compounds > comenic acid
Page last updated: 2024-12-06

comenic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Comenic acid, also known as 5-hydroxy-4-pyrone-2-carboxylic acid, is a naturally occurring compound found in fungi. It is a white crystalline solid that is soluble in water and alcohol. Comenic acid is a potent antioxidant and has been shown to have a number of pharmacological activities, including anti-inflammatory, anti-bacterial, and anti-cancer properties. The compound is synthesized through the fermentation of Aspergillus niger, a type of fungus. It is a precursor to the synthesis of other compounds, such as kojic acid. Its strong antioxidant activity has made it a subject of interest for research. Researchers are investigating its potential as a therapeutic agent for various diseases, including cancer and inflammatory conditions. Comenic acid has also been studied for its ability to inhibit the growth of bacteria and fungi.'

comenic acid: an ingredient of Baliz-2 that may have antibacterial and antioxidant activities [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID68139
CHEMBL ID177875
SCHEMBL ID1171093
MeSH IDM0470505

Synonyms (26)

Synonym
comenic acid
5-hydroxy-4-oxo-4h-pyran-2-carboxylic acid
AO-801/41077391
5-hydroxy-4-oxo-4h-pyran-2-carboxylic acid, 97%
uuuicommfftchs-uhfffaoysa-
inchi=1/c6h4o5/c7-3-1-5(6(9)10)11-2-4(3)8/h1-2,8h,(h,9,10)
KUC106763N
ksc-11-228-7
5-hydroxy-4-oxopyran-2-carboxylic acid
FT-0665161
CHEMBL177875
499-78-5
AKOS005266560
einecs 207-891-7
4h-pyran-2-carboxylic acid, 5-hydroxy-4-oxo-
A827917
5-hydroxy-4-oxo-pyran-2-carboxylic acid;5-hydroxy-4-oxo-4h-pyran-2-carboxylic acid
2-carboxy-5-hydroxy-4-pyrone
SCHEMBL1171093
DTXSID4060103
UUUICOMMFFTCHS-UHFFFAOYSA-N
2-carboxy-5-hydroxypyran-4-one
mfcd03085981
5-hydroxy-4-oxo-4h-pyran-2-carboxylic
5-hydroxy-4-oxo-4h-pyran-2-carboxylicacid
BS-38124

Research Excerpts

Treatment

ExcerptReferenceRelevance
"The treatment with comenic acid leads to switching off the ectopic bursting discharges due to a decrease in the effective charge transferring via the activation gating structure of the slow sodium channels (Na"( Possible mechanism of bursting suppression in nociceptive neurons.
Dick, OE; Krylov, BV; Nozdrachev, AD, 2017)		0.77
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID174351The control period of compound (microg of Fe/h) for biliary excretion of Iron after intravenous administration to the rats1994Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1
Enhancement of iron excretion via monoanionic 3-hydroxypyrid-4-ones.
AID191835The treatment period of compound (microg of Fe/h) for biliary excretion of Iron after intravenous administration to the rats1994Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1
Enhancement of iron excretion via monoanionic 3-hydroxypyrid-4-ones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's1 (6.67)29.6817
2010's11 (73.33)24.3611
2020's2 (13.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.85 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index5.32 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thioctic acid
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.		2.2110dithiolanes;
heterocyclic fatty acid;
thia fatty acid		fundamental metabolite;
geroprotector
melatonin
[no description available]		7.2110acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
deferiprone
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.. deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.		1.98104-pyridonesiron chelator;
protective agent
kojic acid
[no description available]		1.98104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
propofol
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.. propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.		2.1310phenolsanticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.5320dialdehydebiomarker
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.110glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		2.2110ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
lithium
Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.		7.0810alkali metal atom
tetrodotoxin
Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.		2.1510azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
ConditionIndicatedRelationship StrengthStudiesTrials
Anoxemia
[description not available]		02.5420
Hypercapnia
A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.		07.5420
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		07.5420
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.		02.1310
Lead Poisoning, Nervous System
Injury to the nervous system secondary to exposure to lead compounds. Two distinct clinical patterns occur in children (LEAD POISONING, NERVOUS SYSTEM, CHILDHOOD) and adults (LEAD POISONING, NERVOUS SYSTEM, ADULT). In children, lead poisoning typically produces an encephalopathy. In adults, exposure to toxic levels of lead is associated with a peripheral neuropathy.		02.0610
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0610