desipramine has been researched along with Dysthymic Disorder in 2 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Dysthymic Disorder: Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self-esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-six subjects with DSM-III-R dysthymia (70% with superimposed major depression) who had responded to 10 weeks of open-label desipramine (DMI) treatment received 16 additional weeks of continuation DMI." | 9.09 | Six months of desipramine for dysthymia: can dysthymic patients achieve normal social functioning? ( Friedman, RA; Gniwesch, L; Kocsis, JH; Markowitz, JC; Parides, M, 1999) |
| "Forty-six subjects with DSM-III-R dysthymia (70% with superimposed major depression) who had responded to 10 weeks of open-label desipramine (DMI) treatment received 16 additional weeks of continuation DMI." | 5.09 | Six months of desipramine for dysthymia: can dysthymic patients achieve normal social functioning? ( Friedman, RA; Gniwesch, L; Kocsis, JH; Markowitz, JC; Parides, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levitt, AJ | 1 |
| Joffe, RT | 1 |
| Sokolov, ST | 1 |
| Friedman, RA | 1 |
| Markowitz, JC | 1 |
| Parides, M | 1 |
| Gniwesch, L | 1 |
| Kocsis, JH | 1 |
2 trials available for desipramine and Dysthymic Disorder
| Article | Year |
|---|---|
Does the chronological relationship between the onset of dysthymia and major depression influence subsequent response to antidepressants?
Topics: Adolescent; Adult; Aged; Ambulatory Care; Antidepressive Agents; Anxiety Disorders; Comorbidity; Dep | 1998 |
Six months of desipramine for dysthymia: can dysthymic patients achieve normal social functioning?
Topics: Adult; Antidepressive Agents, Tricyclic; Desipramine; Drug Administration Schedule; Dysthymic Disord | 1999 |