sildenafil-citrate and Dysthymic-Disorder

Late onset dysthymic disorder (DD) in middle-aged and elderly men responds poorly to established antidepressants. Previous studies noted an improvement in mood accompanying sildenafil citrate treatment for erectile dysfunction. We sought to evaluate whether sildenafil's mood effects were independent of the effect on erectile function. A 6-week open label study was conducted with 20 male participants, aged 41-60 who were diagnosed with DD and who had normal erectile function. Participants were treated with sildenafil citrate 25 mg per day for 6 weeks. The primary outcome measure was the 21-item Hamilton Depression Rating Scale. Depressive and sexual symptoms were also evaluated using self-report questionnaires. Treatment with sildenafil resulted in a significant reduction in Hamilton Depression Rating Scale mean scores: from 14.61 +/- 3.5 at baseline to 6.39 +/- 5.13 at end of study (F(3,51) = 32.52, p

Topics: Adult; Affect; Aged; Antidepressive Agents; Dysthymic Disorder; Humans; Male; Middle Aged; Personality Inventory; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Treatment Outcome

Topics: Adult; Dysthymic Disorder; Enzyme Inhibitors; Erectile Dysfunction; Female; Humans; Male; Middle Aged; Orgasm; Piperazines; Purines; Selective Serotonin Reuptake Inhibitors; Sexual Dysfunctions, Psychological; Sildenafil Citrate; Sulfones