nortriptyline has been researched along with Dysthymic Disorder in 2 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Dysthymic Disorder: Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self-esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dobkin, RD | 1 |
| Menza, M | 1 |
| Bienfait, KL | 1 |
| Gara, M | 1 |
| Marin, H | 1 |
| Mark, MH | 1 |
| Dicke, A | 1 |
| Friedman, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Depression in Patients With Parkinson's Disease[NCT00062738] | Phase 2 | 52 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
total score on HDRS (0-54 higher score is worse) (NCT00062738)
Timeframe: 8 weeks
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Nortriptyline | 10.84 |
| Paroxetine | 12.45 |
| Placebo | 15.81 |
Percent of patients who had a 50% decrease in total HDRS at 8 weeks (NCT00062738)
Timeframe: 8 weeks
| Intervention | percent of patients who were responders (Number) |
|---|---|
| Nortriptyline | 53 |
| Paroxetine | 11 |
| Placebo | 24 |
1 trial available for nortriptyline and Dysthymic Disorder
| Article | Year |
|---|---|
Depression in Parkinson's disease: symptom improvement and residual symptoms after acute pharmacologic management.
Topics: Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Dysthymic Disorder; Female; | 2011 |
1 other study available for nortriptyline and Dysthymic Disorder
| Article | Year |
|---|---|
Dysthymia. Treating mild depression's major effects.
Topics: Adult; Antidepressive Agents; Cognitive Behavioral Therapy; Depressive Disorder; Dysthymic Disorder; | 1999 |