serine has been researched along with MEA 2a in 6 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "S891A mutation caused medullary thyroid cancer (MTC) in 69." | 1.36 | The clinical spectrum of multiple endocrine neoplasia type 2a caused by the rare intracellular RET mutation S891A. ( Aylwin, S; Beck-Peccoz, P; Diaz-Cano, S; Dralle, H; Fugazzola, L; Izatt, L; Machens, A; McGregor, A; Schulte, KM; Talat, N, 2010) |
| "All MEN 2A affected family members suffered from medullary thyroid carcinoma and two of ten patients for pheochromocytoma." | 1.33 | Novel germline mutation in the transmembrane region of RET gene close to Cys634Ser mutation associated with MEN 2A syndrome. ( Altaner, C; Altanerova, V; Breza, J; Kostalova, L; Poturnajova, M, 2005) |
| "The observed constellation of microcephaly, deafness, cryptorchidism, developmental delay, hypertension, and bilateral pheochromocytoma in association with a VHL mutation A451G in a patient with negative family history has not previously been described in the literature." | 1.32 | Bilateral pheochromocytomas and congenital anomalies associated with a de novo germline mutation in the von Hippel-Lindau gene. ( Assadi, F; Brackbill, EL, 2003) |
| "Here, we report that MEN2A-RET activates Signal Transducer and Activator of Transcription 3 (STAT3) via two YxxV/Q STAT3 docking sites, Tyr752 and Tyr928." | 1.31 | MEN2A-RET-induced cellular transformation by activation of STAT3. ( Buys, CH; Hagens, W; Hofstra, R; Kruijer, W; Schuringa, JJ; Vellenga, E; Wojtachnio, K, 2001) |
| "The clinical association of multiple endocrine neoplasia type 2A (MEN 2A) and Hirschsprung's disease (HD), although rare, has been previously observed." | 1.29 | Mutational analysis of multiple endocrine neoplasia type 2A associated with Hirschsprung's disease. ( Borst, MJ; Decker, RA; Peacock, ML; VanCamp, JM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schulte, KM | 1 |
| Machens, A | 1 |
| Fugazzola, L | 1 |
| McGregor, A | 1 |
| Diaz-Cano, S | 1 |
| Izatt, L | 1 |
| Aylwin, S | 1 |
| Talat, N | 1 |
| Beck-Peccoz, P | 1 |
| Dralle, H | 1 |
| Mian, C | 1 |
| Sartorato, P | 1 |
| Barollo, S | 1 |
| Zane, M | 1 |
| Opocher, G | 1 |
| Assadi, F | 1 |
| Brackbill, EL | 1 |
| Poturnajova, M | 1 |
| Altanerova, V | 1 |
| Kostalova, L | 1 |
| Breza, J | 1 |
| Altaner, C | 1 |
| Borst, MJ | 1 |
| VanCamp, JM | 1 |
| Peacock, ML | 1 |
| Decker, RA | 1 |
| Schuringa, JJ | 1 |
| Wojtachnio, K | 1 |
| Hagens, W | 1 |
| Vellenga, E | 1 |
| Buys, CH | 1 |
| Hofstra, R | 1 |
| Kruijer, W | 1 |
1 review available for serine and MEA 2a
| Article | Year |
|---|---|
RET codon 609 mutations: a contribution for better clinical managing.
Topics: Carcinoma, Medullary; Carcinoma, Neuroendocrine; Codon; Cysteine; Genetic Association Studies; Germ- | 2012 |
5 other studies available for serine and MEA 2a
| Article | Year |
|---|---|
The clinical spectrum of multiple endocrine neoplasia type 2a caused by the rare intracellular RET mutation S891A.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Alanine; Amino Acid Substitutio | 2010 |
Bilateral pheochromocytomas and congenital anomalies associated with a de novo germline mutation in the von Hippel-Lindau gene.
Topics: Adrenal Gland Neoplasms; Amino Acid Substitution; Child; Cryptorchidism; Developmental Disabilities; | 2003 |
Novel germline mutation in the transmembrane region of RET gene close to Cys634Ser mutation associated with MEN 2A syndrome.
Topics: Adrenal Gland Neoplasms; Carcinoma, Medullary; Cysteine; Exons; Female; Gene Frequency; Genetic Link | 2005 |
Mutational analysis of multiple endocrine neoplasia type 2A associated with Hirschsprung's disease.
Topics: Amino Acid Sequence; Base Sequence; Codon; DNA Mutational Analysis; DNA Primers; DNA, Neoplasm; Dros | 1995 |
MEN2A-RET-induced cellular transformation by activation of STAT3.
Topics: 3T3 Cells; Animals; Binding Sites; Cell Division; Cell Line; Cell Transformation, Neoplastic; COS Ce | 2001 |