tyrosine has been researched along with MEA 2a in 19 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 5 (26.32) | 18.2507 |
2000's | 13 (68.42) | 29.6817 |
2010's | 1 (5.26) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Garcia-Barcelo, MM; Lam, KS; Lang, BH; Lee, KE; Lee, PC; Lo, CY; Tam, PK; Wong, KP; Woo, YC; Yu, HW | 1 |
Bongarzone, I; Cassinelli, G; Cremona, M; Cuccuru, G; Gorla, L; Lanzi, C; Miccichè, F; Mondellini, P; Pierotti, MA | 1 |
Bendlova, B; Bilek, R; Dvorakova, K; Dvorakova, S; Skaba, R; Sykorova, V; Vaclavikova, E; Vlcek, P; Zelinka, T | 1 |
Balsalobre, MD; Carbonell, P; Glower, G; Parrilla, P; Pomares, F; Ríos, A; Rodríguez, GJ; Sola, J; Tébar, J; Torregrosa, NM | 1 |
Carlomagno, MS; Cerchia, L; de Franciscis, V; Libri, D | 1 |
Chung, HK; Hwang, ES; Hwang, JH; Jung, HS; Kim, DW; Kim, JM; Park, KC; Park, SH; Park, YJ; Shong, M; Song, JH; Suh, JM; Yun, HJ | 1 |
Becherini, L; Cantini, G; Ercolino, T; Gaglianò, MS; Lombardi, A; Luconi, M; Mannelli, M; Piscitelli, E; Serio, M | 1 |
Asai, N; Iwashita, T; Matsuyama, M; Takahashi, M | 1 |
Asai, N; Iwashita, T; Matsuyama, M; Murakami, H; Takahashi, M | 1 |
Asai, N; Iwashita, T; Murakami, H; Takahashi, M | 1 |
Carlomagno, F; De Vita, G; Fusco, A; Jing, S; Lupoli, G; Melillo, RM; Salvatore, G; Santoro, M; Vecchio, G; Visconti, R; Yu, Y | 1 |
Asai, N; Ito, S; Iwashita, T; Murakami, H; Takahashi, M | 1 |
Bellacosa, A; Billaud, M; Carlomagno, F; Castellone, MD; De Vita, G; Fusco, A; Melillo, RM; Santoro, M; Tsichlis, PN; Visconti, R | 1 |
Hayashi, Y; Iwashita, T; Kato, Y; Kawai, K; Kurokawa, K; Murakamai, H; Takahashi, M; Tohnai, I; Ueda, M | 1 |
Fenzi, G; Fusco, A; Melillo, RM; Monaco, C; Salvatore, D; Santoro, M; Vecchio, G; Visconti, R | 1 |
Hayashi, H; Iwashita, T; Kawai, K; Kurokawa, K; Murakami, H; Takahashi, M | 1 |
Blanes, A; de Miguel, M; Diaz-Cano, SJ; Tashjian, R; Wolfe, HJ | 1 |
Buys, CH; Hagens, W; Hofstra, R; Kruijer, W; Schuringa, JJ; Vellenga, E; Wojtachnio, K | 1 |
Akhand, AA; Hamaguchi, M; Iwashita, T; Kato, M; Kawamoto, Y; Nakashima, I; Senga, T; Sobue, G; Takahashi, M; Takeda, K; Yamamoto, M | 1 |
19 other study(ies) available for tyrosine and MEA 2a
Article | Year |
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Bilateral Pheochromocytomas in MEN2A Syndrome: A Two-Institution Experience.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Age Factors; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Child; Child, Preschool; Codon; Female; Germ-Line Mutation; Glycine; Humans; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Penetrance; Pheochromocytoma; Proto-Oncogene Proteins c-ret; Tryptophan; Tyrosine; Young Adult | 2015 |
Proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations: identification of new signaling elements.
Topics: Animals; Antineoplastic Agents; Carcinoma, Medullary; Epidermal Growth Factor; ErbB Receptors; Female; Gefitinib; Germ-Line Mutation; Humans; Mice; Mice, Nude; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Oncogene Proteins; Phosphorylation; Proteomics; Proto-Oncogene Proteins c-ret; Quinazolines; Signal Transduction; Thyroid Neoplasms; Tyrosine | 2009 |
RET mutation Tyr791Phe: the genetic cause of different diseases derived from neural crest.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Carcinoma, Medullary; Child; Disease; Family; Female; Genetic Association Studies; Germ-Line Mutation; Hirschsprung Disease; Humans; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Neural Crest; Phenylalanine; Polymorphism, Single Nucleotide; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Thyroid Neoplasms; Tyrosine; Young Adult | 2009 |
Prophylactic thyroidectomy in MEN 2A syndrome: experience in a single center.
Topics: Adolescent; Adult; Calcitonin; Child; Child, Preschool; Cysteine; Drosophila Proteins; Female; Humans; Infant; Male; Multiple Endocrine Neoplasia Type 2a; Mutation; Neoplasm Recurrence, Local; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Function Tests; Thyroid Neoplasms; Thyroidectomy; Tyrosine | 2002 |
The soluble ectodomain of RetC634Y inhibits both the wild-type and the constitutively active Ret.
Topics: Amino Acid Substitution; Animals; Binding, Competitive; Cells, Cultured; Cysteine; Dimerization; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glycosylation; Humans; Ligands; Multiple Endocrine Neoplasia Type 2a; Nerve Growth Factors; PC12 Cells; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Solubility; Tyrosine | 2003 |
Regulation of signal transducer and activator of transcription 1 (STAT1) and STAT1-dependent genes by RET/PTC (rearranged in transformation/papillary thyroid carcinoma) oncogenic tyrosine kinases.
Topics: Carcinoma, Papillary; DNA-Binding Proteins; Genes, MHC Class II; HLA-DR Antigens; Humans; Interferon Regulatory Factor-1; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Nuclear Proteins; Oncogene Proteins; Oncogene Proteins, Fusion; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Inhibitors of Activated STAT; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; STAT1 Transcription Factor; Thyroid Neoplasms; Trans-Activators; Transcriptional Activation; Tyrosine | 2004 |
The Y606C RET mutation causes a receptor gain of function.
Topics: Amino Acid Substitution; Animals; Base Sequence; Carcinoma, Medullary; Cysteine; Female; Germ-Line Mutation; Humans; Mice; Middle Aged; Multiple Endocrine Neoplasia Type 2a; NIH 3T3 Cells; Proto-Oncogene Proteins c-ret; Thyroid Neoplasms; Tyrosine | 2008 |
Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Biotin; Blotting, Western; Cadherins; Cell Transformation, Neoplastic; Cytomegalovirus; Drosophila Proteins; Gene Expression Regulation, Neoplastic; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Mutagenesis, Site-Directed; Phosphotyrosine; Point Mutation; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Simian virus 40; Transfection; Tyrosine | 1995 |
Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.
Topics: 3T3 Cells; Animals; Blotting, Western; Cell Transformation, Neoplastic; Codon; Drosophila Proteins; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Mutagenesis, Site-Directed; Point Mutation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Transfection; Tyrosine | 1996 |
A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Drosophila Proteins; Humans; Mice; Molecular Sequence Data; Multiple Endocrine Neoplasia; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Mutation; Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine | 1996 |
Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Drosophila Proteins; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Hirschsprung Disease; Humans; Immunosorbent Techniques; Mice; Multiple Endocrine Neoplasia Type 2a; Mutation; Nerve Growth Factors; Nerve Tissue Proteins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphorylation; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Type C Phospholipases; Tyrosine | 1998 |
Molecular mechanisms of development of multiple endocrine neoplasia 2 by RET mutations.
Topics: Carcinoma, Medullary; Drosophila Proteins; Hirschsprung Disease; Humans; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms; Tyrosine | 1998 |
Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.
Topics: Animals; Blotting, Western; Cell Survival; Chromones; Culture Media, Serum-Free; DNA Fragmentation; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glial Cell Line-Derived Neurotrophic Factor Receptors; In Situ Nick-End Labeling; Ligands; MAP Kinase Signaling System; Morpholines; Multiple Endocrine Neoplasia Type 2a; PC12 Cells; Phosphatidylinositol 3-Kinases; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrosine | 2000 |
Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation.
Topics: Animals; Cell Line; Drosophila Proteins; Enzyme Activation; Enzyme Inhibitors; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Mice; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinases; Multiple Endocrine Neoplasia Type 2a; Mutation; Nerve Growth Factors; Nerve Tissue Proteins; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Tyrosine | 2001 |
Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; COS Cells; Drosophila Proteins; Enzyme Activation; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-ret; ras Proteins; Rats; Receptor Protein-Tyrosine Kinases; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Thyroid Neoplasms; Tyrosine | 2001 |
Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Drosophila Proteins; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; GRB2 Adaptor Protein; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Mice; Molecular Sequence Data; Multiple Endocrine Neoplasia Type 2a; Mutation; Nerve Growth Factors; Nerve Tissue Proteins; Phosphoproteins; Protein Isoforms; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrosine | 2001 |
Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasia.
Topics: Amino Acid Substitution; Antigens, Nuclear; Autoantigens; Calcitonin; Carcinoma, Medullary; Cysteine; DNA Primers; Drosophila Proteins; Female; Focal Epithelial Hyperplasia; Genes, Retinoblastoma; Germ-Line Mutation; Humans; Ki-67 Antigen; Loss of Heterozygosity; Multiple Endocrine Neoplasia Type 2a; Nerve Tissue Proteins; Neurofibromin 1; Nuclear Proteins; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Diseases; Thyroid Neoplasms; Thyroidectomy; Tyrosine | 2001 |
MEN2A-RET-induced cellular transformation by activation of STAT3.
Topics: 3T3 Cells; Animals; Binding Sites; Cell Division; Cell Line; Cell Transformation, Neoplastic; COS Cells; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drosophila Proteins; Enzyme Activation; Genes, Reporter; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Oncogenes; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Serine; STAT3 Transcription Factor; Time Factors; Trans-Activators; Transcriptional Activation; Transfection; Tyrosine; Up-Regulation | 2001 |
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Catalysis; Cell Transformation, Neoplastic; Drosophila Proteins; Humans; Mice; Multiple Endocrine Neoplasia Type 2a; Mutagenesis; Phenylalanine; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; src-Family Kinases; Transfection; Tyrosine | 2002 |