fluorouracil has been researched along with MEA 2a in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Finally, unlike differentiated thyroid cancer, there is no known effective systemic therapy for MTC." | 2.43 | Medullary thyroid carcinoma: including MEN 2A and MEN 2B syndromes. ( Moley, JF; Quayle, FJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gulati, AP | 1 |
| Krantz, B | 1 |
| Moss, RA | 1 |
| Moyal, WN | 1 |
| Tsushima, DA | 1 |
| Mowatt, KB | 1 |
| Schreibman, S | 1 |
| Fine, RL | 1 |
| Quayle, FJ | 1 |
| Moley, JF | 1 |
2 reviews available for fluorouracil and MEA 2a
| Article | Year |
|---|---|
Treatment of multiple endocrine neoplasia 1/2 tumors: case report and review of the literature.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Dacarbazine; Deoxycytidine; Fluorourac | 2013 |
Medullary thyroid carcinoma: including MEN 2A and MEN 2B syndromes.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calcitonin; Carcinoma, Medullary; Combined Modality | 2005 |