cysteine and MEA 2a
cysteine has been researched along with MEA 2a in 32 studies
Research
Studies (32)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 13 (40.63) | 18.2507 |
2000's | 10 (31.25) | 29.6817 |
2010's | 5 (15.63) | 24.3611 |
2020's | 4 (12.50) | 2.80 |
Authors
Authors | Studies |
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Craven, GB; De Castro Ribeiro, O; Goldman, A; Haapanen, O; Liu, Y; Muench, SP; Sharma, V | 1 |
Araki, M; Ikegami, M; Kanno, SI; Kohno, T; Kohsaka, S; Mano, H; Matsumoto, S; Miyoshi, K; Nakaoku, T; Okamoto, A; Okuno, Y; Otsuka, A; Sagae, Y; Sekijima, M; Tabata, J; Ui, A; Yasui, A; Yoshino, R | 1 |
Goldman, A; Liu, Y; Ribeiro, OC; Robinson, J | 1 |
Biarnés, J; de la Bellacasa, JP; Oriola, J; Paniello, B; Sanchez, A | 1 |
Andreou, E; Cariolou, MA; Christophidou-Anastasiadou, V; Christopoulos, G; Fanis, P; Frangos, S; Kleanthous, M; Manoli, P; Mavrommatis, M; Neocleous, V; Nicolaou, S; Phylactou, LA; Skordis, N; Spanou-Aristidou, E; Tanteles, GA | 1 |
Camacho, CP; Cerutti, JM; Delcelo, R; Dias-da-Silva, MR; França, MI; Hoff, AO; Kasamatsu, TS; Lindsey, SC; Machado, AL; Maciel, RM; Salim, CP; Signorini, PS; Valente, FO | 1 |
Boutati, E; Economopoulos, T; Hadjidakis, D; Kamakari, S; Panayiotides, IG; Peppa, M; Peros, G; Pikounis, V; Raptis, SA | 1 |
Mukherjee, S; Zakalik, D | 1 |
Goto, Y; Hossain, K; Iida, M; Kato, M; Kumasaka, MY; Ohgami, N; Takeda, K; Yajima, I | 1 |
Barollo, S; Mian, C; Opocher, G; Sartorato, P; Zane, M | 1 |
Balsalobre, MD; Carbonell, P; Glower, G; Parrilla, P; Pomares, F; Ríos, A; Rodríguez, GJ; Sola, J; Tébar, J; Torregrosa, NM | 1 |
Ezabella, MC; Krieger, JE; Nunes, AB; Pereira, AC; Toledo, SP | 1 |
Carlomagno, MS; Cerchia, L; de Franciscis, V; Libri, D | 1 |
Altaner, C; Altanerova, V; Breza, J; Kostalova, L; Poturnajova, M | 1 |
Fitze, G | 1 |
Abrescia, C; Ibáñez, CF; Kjaer, S; Kurokawa, K; Perrinjaquet, M | 1 |
Becherini, L; Cantini, G; Ercolino, T; Gaglianò, MS; Lombardi, A; Luconi, M; Mannelli, M; Piscitelli, E; Serio, M | 1 |
Eng, C; Gardner, E; Healey, CS; Kwok, JB; Mulligan, LM; Ponder, BA; Ponder, MA | 1 |
Besser, GM; Chew, SL; Clark, AJ; Jain, A; Lavender, P; Ross, RJ; Wass, JA; Weber, A | 1 |
Gagel, RF | 1 |
Komminoth, P | 1 |
Clayton, D; Cote, G; Eng, C; Fink, M; Frank-Raue, K; Gagel, RF; Hendy, GN; Komminoth, P; Lenoir, G; Lips, CJ; Marsh, DJ; Mulligan, LM; Niederle, B; Nishisho, I; Noll, WW; Nordenskjöld, M; Pacini, F; Raue, F; Robinson, BG; Romei, C; Schuffenecker, I; Takai, SI; van Amstel, HK; Xue, F; Zedenius, J | 1 |
Blijham, GH; de Valk, IA; Höppener, JW; Jansen-Schillhorn van Veen, JM; Landsvater, RM; Lips, CJ; Moers, AM; Schaap, C; van Amstel, HK; Vroom, TM | 1 |
Höppner, W; Ritter, MM | 1 |
Betsos, N; Camera, G; Celli, I; Claudiani, F; Romeo, G; Seri, M | 1 |
Asai, N; Ito, S; Iwashita, T; Iwata, Y; Murakami, H; Sobue, G; Takahashi, M | 1 |
Antiñolo, G; Astorga, R; Borrego, S; Conde, AF; Japón, MA; Navarro, E; Sánchez, B | 1 |
Brabant, G; Dralle, H; Höppner, W | 1 |
Antiñolo, G; Borrego, S; Eng, C; Navarro, E; Sáez, ME; Sánchez, B | 1 |
Attié, T; Billaud, M; Chappuis-Flament, S; De Vita, G; Fusco, A; Lenoir, GM; Pasini, A; Santoro, M; Ségouffin-Cariou, C | 1 |
Akhand, AA; Du, J; Hossain, K; Iwashita, T; Kato, M; Kawamoto, Y; Liu, W; Nakashima, I; Oh, C; Suzuki, H; Takahashi, M; Takeda, K; Takeuchi, K; Wu, J; Yoshihara, M | 1 |
Blanes, A; de Miguel, M; Diaz-Cano, SJ; Tashjian, R; Wolfe, HJ | 1 |
Reviews
6 review(s) available for cysteine and MEA 2a
Article | Year |
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Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Carcinoma, Medullary; Cysteine; Female; Glycine; Humans; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Pedigree; Phenotype; Point Mutation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Syndrome; Thyroid Neoplasms; Young Adult | 2008 |
RET codon 804 mutations in multiple endocrine neoplasia 2: genotype-phenotype correlations and implications in clinical management.
Topics: Adolescent; Adult; Child; Child, Preschool; Codon; Cysteine; Female; Genetic Association Studies; Germ-Line Mutation; Humans; Infant; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Penetrance; Point Mutation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Thyroid Neoplasms; Young Adult | 2011 |
RET codon 609 mutations: a contribution for better clinical managing.
Topics: Carcinoma, Medullary; Carcinoma, Neuroendocrine; Codon; Cysteine; Genetic Association Studies; Germ-Line Mutation; Humans; Hyperparathyroidism; Italy; Multiple Endocrine Neoplasia Type 2a; Pedigree; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Serine; Thyroid Neoplasms | 2012 |
Management of patients with hereditary medullary thyroid carcinoma.
Topics: Carcinoma, Medullary; Chromosome Mapping; Cysteine; Genetic Counseling; Hirschsprung Disease; Humans; Multiple Endocrine Neoplasia Type 2a; Mutation, Missense; Oncogene Proteins; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Risk Assessment; Signal Transduction; Thyroid Neoplasms; Thyroidectomy | 2004 |
Putting the bits and pieces of the RET proto-oncogene puzzle together.
Topics: Amino Acid Sequence; Base Sequence; Carcinoma; Cysteine; Drosophila Proteins; Gene Expression; Hirschsprung Disease; Humans; Male; Molecular Sequence Data; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Phosphorylation; Point Mutation; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms | 1995 |
Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation.
Topics: Amino Acid Sequence; Animals; Cysteine; Dimerization; Drosophila Proteins; Enzyme Activation; Humans; Models, Biological; Multiple Endocrine Neoplasia Type 2a; Mutation; Protein Structure, Quaternary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Ultraviolet Rays | 2000 |
Other Studies
26 other study(ies) available for cysteine and MEA 2a
Article | Year |
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Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A.
Topics: Arginine; Carcinogenesis; Cysteine; Humans; Ligands; Multiple Endocrine Neoplasia Type 2a; Point Mutation; Protein Domains; Protein Multimerization; Proto-Oncogene Proteins c-ret | 2022 |
Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis.
Topics: Calcium; Calmodulin; Carcinogenesis; Cysteine; Disulfides; Drosophila Proteins; Humans; Ligands; Multiple Endocrine Neoplasia Type 2a; Mutation; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret | 2022 |
Expression and purification of the extracellular domain of wild-type humanRET and the dimeric oncogenic mutant C634R.
Topics: Animals; Carcinogenesis; Cell Line; Cysteine; Disulfides; HEK293 Cells; Hirschsprung Disease; Humans; Mammals; Multiple Endocrine Neoplasia Type 2a; Mutation; Parkinson Disease; Protein Domains; Proto-Oncogene Proteins c-ret; Recombinant Proteins; Signal Transduction | 2020 |
A novel germline variant in RET gene resulting in an additional cysteine in a family with familial medullary thyroid carcinoma.
Topics: Adult; Aged; Carcinoma, Medullary; Cysteine; Female; Germ-Line Mutation; Heterozygote; Humans; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Pedigree; Phenotype; Prophylactic Surgical Procedures; Proto-Oncogene Proteins c-ret; Thyroid Neoplasms; Thyroidectomy | 2021 |
Multiple endocrine neoplasia 2 in Cyprus: evidence for a founder effect.
Topics: Adult; Arginine; Carcinoma, Medullary; Cohort Studies; Cyprus; Cysteine; Female; Founder Effect; Humans; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Pedigree; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Thyroid Neoplasms | 2018 |
A ten-year clinical update of a large RET p.Gly533Cys kindred with medullary thyroid carcinoma emphasizes the need for an individualized assessment of affected relatives.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Neuroendocrine; Child; Child, Preschool; Cysteine; Family Health; Female; Follow-Up Studies; Glycine; Humans; Male; Metanephrine; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Mutation; Pedigree; Proto-Oncogene Proteins c-ret; Thyroid Neoplasms; Thyroidectomy; Time Factors; Young Adult | 2014 |
L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects.
Topics: Animals; Anticarcinogenic Agents; Arsenites; Carcinogens, Environmental; Cell Survival; Cysteine; Drug Interactions; Enzyme Inhibitors; Matrix Metalloproteinase 2; Mice; Multiple Endocrine Neoplasia Type 2a; NIH 3T3 Cells; Poly(ADP-ribose) Polymerases; Sodium Compounds; Transfection | 2011 |
Prophylactic thyroidectomy in MEN 2A syndrome: experience in a single center.
Topics: Adolescent; Adult; Calcitonin; Child; Child, Preschool; Cysteine; Drosophila Proteins; Female; Humans; Infant; Male; Multiple Endocrine Neoplasia Type 2a; Mutation; Neoplasm Recurrence, Local; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Function Tests; Thyroid Neoplasms; Thyroidectomy; Tyrosine | 2002 |
A novel Val648Ile substitution in RET protooncogene observed in a Cys634Arg multiple endocrine neoplasia type 2A kindred presenting with an adrenocorticotropin-producing pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Amino Acid Substitution; Arginine; Child; Cysteine; Drosophila Proteins; Female; Humans; Isoleucine; Male; Multiple Endocrine Neoplasia Type 2a; Pedigree; Pheochromocytoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Valine | 2002 |
The soluble ectodomain of RetC634Y inhibits both the wild-type and the constitutively active Ret.
Topics: Amino Acid Substitution; Animals; Binding, Competitive; Cells, Cultured; Cysteine; Dimerization; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glycosylation; Humans; Ligands; Multiple Endocrine Neoplasia Type 2a; Nerve Growth Factors; PC12 Cells; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Solubility; Tyrosine | 2003 |
Novel germline mutation in the transmembrane region of RET gene close to Cys634Ser mutation associated with MEN 2A syndrome.
Topics: Adrenal Gland Neoplasms; Carcinoma, Medullary; Cysteine; Exons; Female; Gene Frequency; Genetic Linkage; Germ-Line Mutation; Humans; Male; Multiple Endocrine Neoplasia Type 2a; Oncogene Proteins; Pedigree; Pheochromocytoma; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Serine; Thyroid Neoplasms | 2005 |
Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations.
Topics: Alanine; Amino Acid Sequence; Animals; Cell Membrane; Cysteine; Dimerization; Disulfides; Drosophila melanogaster; Drosophila Proteins; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Humans; Molecular Sequence Data; Multiple Endocrine Neoplasia Type 2a; Mutation; Protein Binding; Proto-Oncogene Proteins c-ret; Sequence Alignment; Sequence Homology, Amino Acid; Thyroid Neoplasms | 2006 |
The Y606C RET mutation causes a receptor gain of function.
Topics: Amino Acid Substitution; Animals; Base Sequence; Carcinoma, Medullary; Cysteine; Female; Germ-Line Mutation; Humans; Mice; Middle Aged; Multiple Endocrine Neoplasia Type 2a; NIH 3T3 Cells; Proto-Oncogene Proteins c-ret; Thyroid Neoplasms; Tyrosine | 2008 |
Haplotype analysis of MEN 2 mutations.
Topics: Amino Acid Sequence; Arginine; Chromosome Mapping; Chromosomes, Human, Pair 10; Codon; Cysteine; Drosophila Proteins; Haplotypes; Humans; Multiple Endocrine Neoplasia Type 2a; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Restriction Mapping | 1994 |
Absence of mutations in the MEN2A region of the ret proto-oncogene in non-MEN 2A phaeochromocytomas.
Topics: Adrenal Gland Neoplasms; Arginine; Base Sequence; Codon; Cysteine; Drosophila Proteins; Humans; Molecular Sequence Data; Multiple Endocrine Neoplasia Type 2a; Paraganglioma; Pheochromocytoma; Point Mutation; Polymerase Chain Reaction; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases | 1995 |
Rudolf-Virchow-Preis 1995. The role of RET proto-oncogene mutation analysis in the diagnosis of multiple endocrine neoplasia type 2 (MEN 2) gene carriers and in the discrimination of sporadic and familial medullary thyroid carcinomas and pheochromocytomas
Topics: Adrenal Gland Neoplasms; Awards and Prizes; Codon; Cysteine; Diagnosis, Differential; Drosophila Proteins; Genetic Carrier Screening; Humans; Hyperplasia; Methionine; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Pathology; Pheochromocytoma; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Threonine; Thyroid Neoplasms | 1995 |
The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis.
Topics: Carcinoma, Medullary; Codon; Cysteine; Drosophila Proteins; Hirschsprung Disease; Humans; Hyperparathyroidism; Multiple Endocrine Neoplasia Type 2a; Mutation; Phenotype; Pheochromocytoma; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms | 1996 |
Familial medullary thyroid carcinoma: not a distinct entity? Genotype-phenotype correlation in a large family.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Carcinoma, Medullary; Cysteine; DNA Probes; Drosophila Proteins; Female; Genotype; Germ-Line Mutation; Humans; Hyperparathyroidism; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Pedigree; Phenotype; Pheochromocytoma; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms | 1996 |
A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A.
Topics: Alleles; Cysteine; Drosophila Proteins; Electrophoresis, Polyacrylamide Gel; Exons; Female; Humans; Hypercalcemia; Hyperplasia; Male; Multiple Endocrine Neoplasia Type 2a; Mutation; Parathyroid Glands; Pedigree; Phenotype; Polymerase Chain Reaction; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Repetitive Sequences, Nucleic Acid; Sequence Analysis | 1997 |
A Cys634Gly substitution of the RET proto-oncogene in a family with recurrence of multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis.
Topics: Adolescent; Adult; Amyloidosis; Child; Cysteine; Deoxyribonucleases, Type II Site-Specific; Drosophila Proteins; Female; Glycine; Humans; Lichenoid Eruptions; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Mutation; Pedigree; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Sequence Analysis, DNA | 1997 |
Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype.
Topics: 3T3 Cells; Animals; Carcinoma, Medullary; Cysteine; Drosophila Proteins; Hirschsprung Disease; Humans; Mice; Molecular Weight; Multiple Endocrine Neoplasia Type 2a; Mutation; Phenotype; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms | 1997 |
Cys 634 mutations in the RET proto-oncogene in Spanish families affected by MEN 2A.
Topics: Amino Acid Substitution; Cysteine; DNA; DNA Mutational Analysis; Drosophila Proteins; Family Health; Female; Humans; Male; Multiple Endocrine Neoplasia Type 2a; Mutation; Mutation, Missense; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Spain | 1998 |
Duplication of 9 base pairs in the critical cysteine-rich domain of the RET proto-oncogene causes multiple endocrine neoplasia type 2A.
Topics: Amino Acid Sequence; Base Sequence; Cysteine; DNA; DNA Mutational Analysis; Drosophila Proteins; Exons; Gene Duplication; Humans; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases | 1998 |
Molecular analysis of the ret and GDNF genes in a family with multiple endocrine neoplasia type 2A and Hirschsprung disease.
Topics: Aged; Child, Preschool; Cysteine; DNA; Drosophila Proteins; Female; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Hirschsprung Disease; Humans; Male; Middle Aged; Multiple Endocrine Neoplasia Type 2a; Nerve Growth Factors; Nerve Tissue Proteins; Pedigree; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases | 1998 |
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Cell Transformation, Neoplastic; Cysteine; Dimerization; Disulfides; Drosophila Proteins; Glycosylation; Hirschsprung Disease; Humans; Membrane Proteins; Mice; Models, Biological; Multiple Endocrine Neoplasia Type 2a; PC12 Cells; Phosphotyrosine; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Transcriptional Activation | 1998 |
Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasia.
Topics: Amino Acid Substitution; Antigens, Nuclear; Autoantigens; Calcitonin; Carcinoma, Medullary; Cysteine; DNA Primers; Drosophila Proteins; Female; Focal Epithelial Hyperplasia; Genes, Retinoblastoma; Germ-Line Mutation; Humans; Ki-67 Antigen; Loss of Heterozygosity; Multiple Endocrine Neoplasia Type 2a; Nerve Tissue Proteins; Neurofibromin 1; Nuclear Proteins; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Thyroid Diseases; Thyroid Neoplasms; Thyroidectomy; Tyrosine | 2001 |