A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)
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| "POEMS syndrome is an unusual multisystem disorder associated frequently with polyneuropathy, organomegaly, endocrinopathy, M-protein change and skin lesion." | ( Lin, GW; Yu, LY; Zhu, B, 1994) |
| "The POEMS syndrome is a synopsis of different symptoms such as polyneuropathy, organomegaly, endocrine disturbances, M-protein and skin changes." | ( Dressnandt, J; Drosner, M; Klingelhöfer, J; Näher-Noé, M, 1993) |
| "POEMS syndrome is an uncommon association of polyneuropathy, organomegaly (liver, spleen, lymph nodes), endocrinopathy (hypogonadism primary hypothyroidism, diabetes mellitus, adrenal insufficiency), monoclonal gammopathy and skin changes; bone lesions (generally osteosclerotic, less frequently osteolytic or mixed) are nearly always present in this multisystem disease." | ( Bertola, G; Bocchia, M; Mattioli, M; Meregalli, M; Torchio, G, 1995) |
| "POEMS syndrome is a multisystem disorder associated with plasma cell dyscrasia." | ( Chaine, G; Fanjkuchen, F; Gatinel, D; Guillevin, L; Larroche, C, 1998) |
| "POEMS syndrome is a multisystem disorder." | ( Bertherat, J; Luton, JP; Mauvais-Jarvis, F; Ravaud, H; Thomopoulos, P, 1998) |
| "POEMS syndrome is a rare synopsis of different multisystemic disorders (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammapathy, and skin lesions) associated with plasma cell dyscrasia." | ( Albitar, S; Bourgeon, B; Genin, R; Jacquesson, M; Ribera, A; Riviere, JP; Serveaux, JP; Serveaux, MO, 1998) |
| "POEMS syndrome is a rare condition with cutaneous manifestations commonly including angiomas, hypertrichosis, hyperpigmentation, and thickening of the skin." | ( Feller, AC; Meigel, W; Mensing, H; Ramsauer, J; Stemm, AV; Weichenthal, M, 1999) |
| "POEMS syndrome is a rare form of plasma-cell dyscrasia characterized by the various association of Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal component and Skin changes." | ( Geniaux, M; Labbe, L; Sibaud, V; Toussaint, P, 2000) |
| "The POEMS syndrome is a multisystem disorder characterised by polyneuropathy, organomegaly, endocrinopathy, plasma cell dyscrasia and skin changes." | ( Kiessling, B; Klotz, JM; Langohr, HD; Rössler, M, 2004) |
| "POEMS syndrome is a syndrome that presents with polyneuropathy, organomegaly, endocrinopathy, M-proteins and skin changes." | ( Kameyama, M; Kubori, T; Matsui, H; Nishinaka, K; Oda, M; Udaka, F, 2004) |
| "POEMS syndrome is a rare plasma cell disorder, characterized by polyneuropathy, organomegaly, endocrinopathy, serum monoclonal protein, and skin lesions." | ( Goto, T; Karube, H; Matsubara, M; Nakamichi, T; Ookawara, S; Saito, M; Sanada, S; Shindo, T; Suzuki, M, 2006) |
| "The pathogenesis of POEMS syndrome is not well understood; however overproduction of vascular endothelial growth factor (VEGF), probably secreted by plasmacytoma, may be responsible for most of the characteristic symptoms, including neuropathy." | ( Misawa, S, 2008) |
| "The pathogenesis of POEMS syndrome is not well understood, but overproduction of vascular endothelial growth factor (VEGF), probably secreted by plasmacytoma, may be responsible for most of its characteristic symptoms." | ( Kuwabara, S, 2008) |
| "The POEMS syndrome is a rare plasma cell disease." | ( Athanazio, RA; Dias, SA; Jardim, C; Rached, S; Souza, R, 2009) |
| "POEMS syndrome is defined by the presence of a peripheral neuropathy (P), a monoclonal plasma cell disorder (M), and other paraneoplastic features, the most common of which include organomegaly (O), endocrinopathy (E), skin changes (S)." | ( Fadjari, TH; Oehadian, A; Prasetya, D, 2010) |
| "A POEMS syndrome is a rare disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin abnormalities including hyperpigmentation and hypertrichosis." | ( Hata, H; Kawano, Y; Kimura, E; Maruyoshi, N; Mitsuya, H; Nakama, T; Uchino, M, 2010) |
| "POEMS syndrome is a rare plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes." | ( Duan, MH; Huang, Z; Jiao, L; Li, J; Shen, T; Zhang, W; Zhao, YQ; Zhou, DB, 2011) |
| "POEMS syndrome is a rare clonal plasma cell disorder without standard treatment." | ( Duan, MH; Guan, HZ; Jiao, L; Li, J; Tian, Z; Zhang, W; Zhou, DB; Zhu, WG, 2011) |
| "POEMS syndrome is a rare paraneoplastic syndrome due to a plasma cell dyscrasia, which includes peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma cell proliferation and skin changes." | ( Albrecht, P; Braun, SA; Hanneken, S; Methner, A, 2011) |
| "POEMS syndrome is a rare paraneoplastic condition related to myeloma." | ( Dispenzieri, A; Kohut, IE; Warsame, R, 2012) |
| "POEMS syndrome is a rare paraneoplastic condition associated to an underlying plasmacellular dyscrasia." | ( Balducci, M; Chiusolo, P; De Stefano, V; Giannotta, C; Laurenti, L; Leone, G; Luigetti, M; Sabatelli, M; Sica, S; Sorà, F; Vannata, B, 2012) |
| "The pathogenesis of POEMS syndrome is not well understood, but overproduction of vascular endothelial growth factor (VEGF), probably secreted by plasmacytomas, is likely to be responsible for most of the characteristic symptoms." | ( Arimura, K; Dispenzieri, A; Kuwabara, S; Misawa, S; Nakaseko, C, 2012) |
| "POEMS syndrome is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes." | ( Li, J; Liu, T; Niu, T; Wei, Q; Yang, JR; Yang, YM; Zeng, K, 2013) |
| "POEMS syndrome is a rare disorder characterized by polyneuropathy, monoclonal gammopathy, multiorgan involvement, and elevated vascular endothelial growth factor levels." | ( Abraham, J; Asli, B; Banos, A; Brisseau, JM; Choquet, S; Decaux, O; Deplanque, G; Facon, T; Fermand, JP; Galicier, L; Godmer, P; Guichard, I; Haroche, J; Hermine, O; Jaccard, A; Leblond, V; Leleu, X; Marolleau, JP; Merlusca, L; Musset, L; Recher, C; Roussel, M; Royer, B; Sebban, C, 2013) |
| "POEMS syndrome is a clonal plasma cell disease characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes." | ( Li, J; Zhou, DB, 2013) |
| "POEMS syndrome is potentially fatal disease, and patients' quality of life deteriorates because of progressive neuropathy and/or massive peripheral edema or pleural effusion/ascites." | ( Kuwabara, S, 2013) |
| "POEMS syndrome is a potentially fatal disease, and prediction of prognostic factors for POEMS syndrome is important for clinicians." | ( Cui, R; Huang, X; Pu, C; Tian, C; Yu, S; Zhang, J, 2014) |
| "POEMS syndrome is a monoclonal plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes." | ( Hagihara, M; Hattori, Y; Ishigatsubo, Y; Ishii, Y; Ishiyama, Y; Tomita, N; Yamamoto, E; Yamazaki, E, 2013) |
| "POEMS syndrome is rare, but this syndrome should be included in the differential diagnosis of chylothorax with unexplained etiology." | ( Aoki, A; Ikeda, N; Kudo, Y; Miura, H; Nakajima, E; Takahashi, H, 2014) |
| "POEMS syndrome is a very rare disease and cardiac involvement in POEMS syndrome is rarely reported." | ( Chen, Y; Luo, Y; Pei, G; Sun, J; Yan, J; Yang, D, 2015) |
| "POEMS syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell neoplasm." | ( Cai, Q; Cao, X; Huang, X; Li, J; Wang, C; Yang, H; Zhou, D, 2016) |
| "POEMS syndrome is a rare paraneoplastic condition, with a poorly understood pathogenesis." | ( Autore, F; Bacigalupo, A; Chiusolo, P; Innocenti, I; Laurenti, L; Luigetti, M; Piccirillo, N; Sica, S; Sora, F, 2018) |
| "POEMS syndrome is the syndrome of Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and typical Skin changes." | ( Abdul Muttlib, FA; Abdul Wahid, SFS; Leong, CF; Masir, N; Nyunt, WWT; Remli, R; Tumian, NR, 2017) |
| "POEMS syndrome is associated with plasma cell dyscrasias and upregulation of vascular endothelial growth factor leading to systemic oedema, papilloedema and pulmonary hypertension." | ( Gilbert, L; Ordway, S; Wanko, S, 2018) |
| "POEMS syndrome is a rare plasma cell dyscrasia." | ( Cai, H; Cao, XX; Feng, J; Gao, XM; Huang, XF; Li, J; Zhang, L; Zhao, H; Zhou, DB, 2019) |
| "The diagnosis of POEMS syndrome is made with three of the major criteria, two of which must include polyradiculoneuropathy and clonal PCD, and at least one of the minor criteria." | ( Dispenzieri, A, 2019) |
| "POEMS syndrome is a rare plasma cell disorder." | ( Cai, H; Cai, QQ; Cao, XX; Gao, XM; Le, J; Li, J; Zhao, H, 2021) |
| "POEMS syndrome is a rare multisystem paraneoplastic disorder due to an underlying low-level plasma cell dyscrasia." | ( D'Sa, S; Khwaja, J; Lunn, MP; Sive, J, 2023) |
| "POEMS syndrome is a rare disorder which has been increasingly recognized." | ( Hong, L; Huang, H; Lin, Z; Lu, J; Luo, L; Wang, C; Wang, X; Xu, R; Zhou, L, 2023) |