Page last updated: 2024-09-28

Cutis Laxa

A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)

Synonyms(3)

Synonym
Cutis Laxa
Dermatomegaly
Dermatolysis

Research Excerpts

Overview

ExcerptReference
"Cutis laxa is a genetically heterogeneous connective tissue disease that occurs in both inherited and acquired forms."( Byers, PH; Davidson, JM; Holbrook, KA; Sephel, GC, 1989)
"Inherited cutis laxa is a connective tissue disorder characterized by loose skin and variable internal organ involvement, resulting from paucity of elastic fibers."( Chu, ML; Kostka, G; Markova, D; Ringpfeil, F; Sasaki, T; Timpl, R; Uitto, J; Zou, Y, 2003)
"Cutis laxa is an extremely rare disorder characterized by marked skin laxity."( Badenas, C; Carrió, A; Iranzo, P; Milà, M; Puig, S; Rodriguez-Revenga, L, 2004)
"Congenital cutis laxa is a genetically heterogeneous condition presenting with loose and redundant skin folds, decreased elasticity of the skin, connective tissue involvement and a highly variable spectrum of associated features."( Coucke, P; Gillessen-Kaesbach, G; Grünewald, S; Morava, E; Smeitink, J; Voit, T; Wevers, R; Wopereis, S, 2005)
"Cutis laxa is an acquired or inherited condition characterized by redundant, pendulous and inelastic skin."( Crepeau, MW; Kirk, RC; Mitchell, AL; Puntel, RA; Stephan, MJ; Szabo, Z; Urban, Z; Yin Loke, K, 2006)
"The complexity of cutis laxa is emphasized by the fact that as many as 10 distinct genes can harbour mutations in this and related disorders."( Li, Q; Uitto, J; Urban, Z, 2013)

Context

ExcerptReference
"Few cases of cutis laxa have been described worldwide."( Badenas, C; Carrió, A; Iranzo, P; Milà, M; Puig, S; Rodriguez-Revenga, L, 2004)
"Autosomal dominant cutis laxa has been described as a benign disease with minor systemic involvement."( Crepeau, MW; Kirk, RC; Mitchell, AL; Puntel, RA; Stephan, MJ; Szabo, Z; Urban, Z; Yin Loke, K, 2006)

Treatment

ExcerptReference
"We report a case of fulminant toxic dermatolysis, tissue necrosis and impaired wound healing resulting in the amputation of one forefoot after 6 days of treatment with sunitinib."( Feyerabend, S; Schilling, D; Stenzl, A; Wicke, C, 2009)
"Although there is no satisfactory treatment for cutis laxa, dapsone can be used in the acute phase for control of swelling."( Agarwal, P; Baghela, B; Jagati, A; Saikia, S; Shrivastava, S, 2020)

Research

Studies (154)

TimeframeStudies, This Condition (%)All Conditions %
pre-199045 (29.22)23.3326
1990's16 (10.39)12.5806
2000's34 (22.08)18.1394
2010's44 (28.57)28.8240
2020's15 (9.74)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
glycine0low10
pyridoxal0low10
vanilmandelic acid0medium11
azathioprine0low10
celecoxib0low10
citalopram0low10
dapsone0low20
disulfiram0medium11
hydroxychloroquine0low20
isoniazid0low10
2-propanol0low10
khellin0low10
apnea0low10
thalidomide0low10
prednisolone0low10
hydroxyproline0low30
penicillamine0low140
prednisone0low10
lysine0low10
ornithine0low10
arginine0low10
pyrroles0low10
pyrazines0low20
betamethasone0low10
reticulin0low10
ethylnitrosourea0low10
isodesmosine0low10
fluorescein-5-isothiocyanate0low10
manganese0low10
mercury0low10
molybdenum0low10
plutonium0low10
trolamine salicylate0low20
tetradecanoylphorbol acetate0low10
triamcinolone0low10
transferrin0low50
glutamic acid0low10
propiconazole0low10
clarithromycin0low10
methotrexate0low10
proline0low50
betamethasone-17,21-dipropionate0low10
bortezomib0low20
elastin0low650
inositol 3-phosphate0low10
tretinoin0low10
tacrolimus0low10
nadp0low10
hydroxylysine0low10
vitamin k semiquinone radical0low20
brefeldin a0low10
latanoprost0low10
su 112480low10
succinyl-trialanine-4-nitroanilide0low10
losartan potassium0low10
nad0low10
desmosine0low30
glycolipids0low10
epidermal growth factor0low10
transforming growth factor beta0low80
hyaluronoglucosaminidase0low10
cyclosporine0low10
eye0low20

Protein Targets (1,272)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma140014
GLI family zinc finger 3160016
AR protein210021
aldehyde dehydrogenase 1 family, member A1110011
retinoic acid nuclear receptor alpha variant 1120012
retinoid X nuclear receptor alpha140014
estrogen nuclear receptor alpha220022
peroxisome proliferator-activated receptor delta100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
activating transcription factor 67007
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x8008
thyroid hormone receptor beta isoform a7007
heat shock protein beta-19009
nuclear factor erythroid 2-related factor 2 isoform 1160016
lamin isoform A-delta10120012
Voltage-dependent calcium channel gamma-2 subunit110011
Glutamate receptor 2112114
thioredoxin reductase130013
ATAD5 protein, partial6006
TDP1 protein180018
Microtubule-associated protein tau8008
estrogen-related nuclear receptor alpha180018
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 2190019
Bloom syndrome protein isoform 17007
D(1A) dopamine receptor3003
neuropeptide S receptor isoform A3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
phosphopantetheinyl transferase110011
NFKB1 protein, partial3003
GLS protein7007
thyroid stimulating hormone receptor4004
alpha-galactosidase2002
cytochrome P450 2C19 precursor3003
chromobox protein homolog 19009
flap endonuclease 15005
DNA polymerase iota isoform a (long)7007
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)4004
Cytochrome P450 3A40618
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30202
ATP-dependent phosphofructokinase6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain8008
interleukin 83003
acetylcholinesterase2002
SMAD family member 26006
Fumarate hydratase3003
SMAD family member 36006
thioredoxin glutathione reductase7007
nuclear receptor subfamily 1, group I, member 3110011
EWS/FLI fusion protein9009
glucocorticoid receptor [Homo sapiens]150015
farnesoid X nuclear receptor100010
pregnane X nuclear receptor110011
G8008
polyprotein3003
P531001
peroxisome proliferator activated receptor gamma100010
IDH16006
aryl hydrocarbon receptor8008
thyroid stimulating hormone receptor5005
peripheral myelin protein 22 isoform 13003
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 2130013
geminin180018
peripheral myelin protein 22100010
survival motor neuron protein isoform d7007
cytochrome P450 3A4 isoform 18008
M-phase phosphoprotein 84004
muscleblind-like protein 1 isoform 15005
Gamma-aminobutyric acid receptor subunit pi8008
ATP-binding cassette sub-family C member 3017017
Multidrug resistance-associated protein 4017018
Bile salt export pump0606
Bile salt export pump023023
Interferon beta130013
HLA class I histocompatibility antigen, B alpha chain 8008
Cellular tumor antigen p53120012
Gamma-aminobutyric acid receptor subunit beta-18008
Gamma-aminobutyric acid receptor subunit delta8008
Gamma-aminobutyric acid receptor subunit gamma-28008
Gamma-aminobutyric acid receptor subunit alpha-58008
Gamma-aminobutyric acid receptor subunit alpha-38008
Gamma-aminobutyric acid receptor subunit gamma-18008
Gamma-aminobutyric acid receptor subunit alpha-28008
Gamma-aminobutyric acid receptor subunit alpha-48008
Gamma-aminobutyric acid receptor subunit gamma-38008
Gamma-aminobutyric acid receptor subunit alpha-68008
Nuclear receptor ROR-gamma4116
Gamma-aminobutyric acid receptor subunit alpha-18109
Gamma-aminobutyric acid receptor subunit beta-38008
Gamma-aminobutyric acid receptor subunit beta-28008
GABA theta subunit8008
Inositol hexakisphosphate kinase 18008
Canalicular multispecific organic anion transporter 1016016
ATPase family AAA domain-containing protein 5100010
Ataxin-2120012
Gamma-aminobutyric acid receptor subunit epsilon8008
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial8008
pregnane X receptor6006
progesterone receptor120012
cytochrome P450 family 3 subfamily A polypeptide 4140014
vitamin D (1,25- dihydroxyvitamin D3) receptor130013
nuclear receptor subfamily 1, group I, member 23003
nuclear factor erythroid 2-related factor 2 isoform 28008
galanin receptor type 30101
Glucocorticoid receptor010217
Glycine receptor subunit alpha-1010010
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
ORF730011
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
PPM1D protein5005
caspase 7, apoptosis-related cysteine protease3003
estrogen receptor 2 (ER beta)8008
caspase-33003
Caspase-74004
caspase-34004
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30202
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120303
Prothrombin0112
Chymotrypsinogen A0101
Carbonic anhydrase 10708
Carbonic anhydrase 20719
Carbonic anhydrase 30303
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Carbonic anhydrase 40303
Carbonic anhydrase 60505
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0303
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70303
26S proteasome regulatory subunit 6B0112
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10202
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10202
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90404
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130202
NACHT, LRR and PYD domains-containing protein 3 0202
Proteasome subunit alpha-type 80101
Histone deacetylase 20202
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Carbonic anhydrase 150303
Histone deacetylase 80202
Histone deacetylase 60202
Carbonic anhydrase 140303
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0303
PAX80001
USP1 protein, partial9009
Smad36006
67.9K protein5005
NPC intracellular cholesterol transporter 1 precursor2002
major prion protein preproprotein Prp precursor0101
nuclear receptor subfamily 0 group B member 10101
ras-related protein Rab-9A1001
steroidogenic factor 10101
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Chain A, Carbonic anhydrase II0101
Chain A, Cruzipain5005
Carbonic anhydrase 0001
Carbonic anhydrase 0101
GTP-binding protein (rab7)0011
ras protein, partial0011
glp-1 receptor, partial5005
cytochrome P450 2D65005
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
thyrotropin-releasing hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
interferon gamma precursor0001
prostaglandin E2 receptor EP2 subtype0001
potassium voltage-gated channel subfamily H member 2 isoform d4004
Prostaglandin E synthase0101
3-phosphoinositide-dependent protein kinase 10112
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0202
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Cytochrome c oxidase subunit 20101
Prostaglandin G/H synthase 10202
Procathepsin L0325
Aldo-keto reductase family 1 member B10606
Seed linoleate 13S-lipoxygenase-10101
Neuronal acetylcholine receptor subunit alpha-40101
Polyunsaturated fatty acid 5-lipoxygenase0101
Quinolone resistance protein NorA0101
Adenosine receptor A30606
Cytochrome P450 2D60213
Cytochrome P450 2C9 0415
Neuronal acetylcholine receptor subunit beta-20101
Beta-3 adrenergic receptor0202
Alpha-1B adrenergic receptor0606
Calpain-2 catalytic subunit0101
Alpha-2B adrenergic receptor0606
5-hydroxytryptamine receptor 1A0303
D(1A) dopamine receptor0404
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10203
Sodium-dependent noradrenaline transporter 0606
Adenosine receptor A10101
Cruzipain0101
Sodium/hydrogen exchanger 10101
Indoleamine 2,3-dioxygenase 10202
Sodium-dependent serotonin transporter0617
Sodium-dependent serotonin transporter0112
Delta-type opioid receptor0101
Delta-type opioid receptor0202
Mu-type opioid receptor0202
Bifunctional epoxide hydrolase 20202
Prostaglandin G/H synthase 20427
Prostaglandin G/H synthase 2 0101
Carbonic anhydrase0101
Alpha-1A adrenergic receptor0606
Urotensin-2 receptor0101
Carbonic anhydrase0101
Histone deacetylase 40101
Ras-related protein Rab-2A0011
D(2) dopamine receptor0101
Prostaglandin G/H synthase 20303
Carbonic anhydrase 0101
Mu-type opioid receptor0303
Carbonic anhydrase 20101
Sodium-dependent dopamine transporter 0505
Prostaglandin G/H synthase 20101
Mitogen-activated protein kinase 140112
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Sigma intracellular receptor 20202
Delta carbonic anhydrase0101
Prostaglandin G/H synthase 1 0101
Carbonic anhydrase 0101
Prostaglandin G/H synthase 10101
Cyclooxygenase-2 0101
Histone deacetylase 70101
Rap guanine nucleotide exchange factor 41001
Carbonic anhydrase 40202
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
P2Y purinoceptor 120101
Histone deacetylase 90101
Histone deacetylase 50101
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0202
Spike glycoprotein0224
Replicase polyprotein 1ab0224
glucose-6-phosphate 1-dehydrogenase isoform b0202
Transmembrane protease serine 20224
Dihydrofolate reductase 0202
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein1203
Histidine-rich protein PFHRP-II0102
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0404
Replicase polyprotein 1a0224
Replicase polyprotein 1ab0224
Replicase polyprotein 1ab0426
Spike glycoprotein0101
Replicase polyprotein 1ab0426
Muscarinic acetylcholine receptor M10202
Ribosyldihydronicotinamide dehydrogenase [quinone]0112
Alpha-2C adrenergic receptor0202
DNA ligase 10101
Muscarinic acetylcholine receptor M30202
Serine/threonine-protein kinase mTOR0314
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Spike glycoprotein4228
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20707
Sigma intracellular receptor 20202
Phosphoethanolamine N-methyltransferase0101
Sigma non-opioid intracellular receptor 10404
Angiotensin-converting enzyme 2 0224
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
Solute carrier family 22 member 1 0202
Sodium-dependent noradrenaline transporter0101
5-hydroxytryptamine receptor 40202
Tryptophan 5-hydroxylase 10101
Angiotensin-converting enzyme0202
Aldo-keto reductase family 1 member B10101
Acetylcholinesterase0303
Aromatase0101
Sodium-dependent dopamine transporter0101
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2C0202
Histamine H1 receptor0202
5-hydroxytryptamine receptor 2B0606
5-hydroxytryptamine receptor 70101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Nuclear receptor subfamily 3 group C member 3 0202
Sigma non-opioid intracellular receptor 10101
Transporter0202
importin subunit beta-1 isoform 13003
mitogen-activated protein kinase 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 12002
streptokinase A precursor0011
ATP-dependent translocase ABCB10101
Solute carrier organic anion transporter family member 1B30102
Solute carrier organic anion transporter family member 1B10202
Thromboxane A2 receptor 0112
Prostaglandin E2 receptor EP1 subtype0112
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin F2-alpha receptor0213
Prostaglandin E2 receptor EP3 subtype0112
Prostaglandin E2 receptor EP2 subtype0101
Prostacyclin receptor0101
Prostaglandin D2 receptor0101
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
bromodomain adjacent to zinc finger domain 2B4004
cytochrome P450 2C9 precursor2002
Myeloperoxidase0202
Dihydrofolate reductase0303
Histamine H2 receptor3003
5-hydroxytryptamine receptor 60303
Chain A, Beta-lactamase7007
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase3003
15-lipoxygenase, partial2002
Thrombopoietin1001
apical membrane antigen 1, AMA11001
hypothetical protein, conserved1001
regulator of G-protein signaling 43003
nonstructural protein 14004
pyruvate kinase1001
LacZ protein (plasmid)0011
beta-2 adrenergic receptor3003
type-1 angiotensin II receptor0101
polyunsaturated fatty acid lipoxygenase ALOX122002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
atrial natriuretic peptide receptor 1 precursor2002
runt-related transcription factor 1 isoform AML1b1001
perilipin-50101
vitamin D3 receptor isoform VDRA7007
perilipin-10101
histone deacetylase 9 isoform 31001
core-binding factor subunit beta isoform 21001
huntingtin isoform 22002
polypyrimidine tract-binding protein 1 isoform a1001
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
serine/threonine-protein kinase PLK11001
apelin receptor0101
heat shock protein HSP 90-alpha isoform 20002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
nuclear receptor ROR-gamma isoform 17007
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Vpr1001
histone acetyltransferase KAT2A isoform 18008
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
pyruvate kinase PKM isoform b1001
Fatty-acid amide hydrolase 10101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transient receptor potential cation channel subfamily A member 10011
Carbamate kinase0101
Retinal dehydrogenase 10101
Aldehyde dehydrogenase, mitochondrial0101
Integrin beta-32013
Cytochrome P450 1A20415
Integrin alpha-IIb2013
Ornithine decarboxylase1002
Fructose-1,6-bisphosphatase 10101
Polyunsaturated fatty acid lipoxygenase ALOX150101
D(2) dopamine receptor0202
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0202
C-X-C chemokine receptor type 20202
Mitogen-activated protein kinase 3 0112
Protein-lysine 6-oxidase0101
Lysine-specific demethylase 5A0101
Caspase-10101
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Alpha-synuclein1102
Kappa-type opioid receptor0202
C-C chemokine receptor type 20202
C-C chemokine receptor type 40202
C-C chemokine receptor type 50202
Gasdermin-D0101
Lysyl oxidase homolog 30101
Inositol monophosphatase 11001
TAR DNA-binding protein 433003
Lysyl oxidase homolog 40101
Histone-lysine N-methyltransferase EHMT20101
Monoglyceride lipase0101
Gasdermin-D0101
Histone-lysine N-methyltransferase EHMT10101
Lysyl oxidase homolog 20101
heat shock protein 90, putative0002
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0404
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, NMDA 1 0527
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 0426
Glutamate receptor ionotropic, NMDA 2B0426
Glutamate receptor ionotropic, NMDA 2C0426
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0426
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0426
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0426
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10101
Proton-coupled amino acid transporter 10303
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Genome polyprotein 0101
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
Glutamine synthetase0101
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
Chain A, 2-oxoglutarate Oxygenase6006
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
cytochrome P450 2D6 isoform 12002
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20203
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Cytochrome P450 2C190213
Endonuclease III-like protein 10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
Pantothenate synthetase0101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0202
Endonuclease 8-like 10101
GALC protein1001
Cytochrome P450 1A10202
Cytochrome P450 1B10101
Solute carrier organic anion transporter family member 2A10101
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor1001
ClpP1001
Thymidylate synthase 0101
Thymidylate synthase 0101
transcriptional regulator ERG isoform 31001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 16006
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10134
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20123
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60102
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Estrogen receptor0404
Sex hormone-binding globulin0011
Estrogen receptor0011
Progesterone receptor0427
Androgen receptor0303
Estrogen receptor beta0011
Chain A, ARGINASE 10101
Chain A, Arginase 10101
Chain A, ARGINASE 10101
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE0101
Cystathionine gamma-lyase0202
Succinyl-diaminopimelate desuccinylase0101
luciferase0001
Fatty acid-binding protein, liver0101
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20202
Estrogen receptor beta0202
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
Guanine nucleotide-binding protein G1001
Pyridoxal kinase0012
Aldehyde oxidase0101
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0012
Solute carrier family 22 member 60101
5'-AMP-activated protein kinase subunit beta-20001
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
5'-AMP-activated protein kinase subunit gamma-10012
5'-AMP-activated protein kinase catalytic subunit alpha-20113
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10113
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20012
5'-AMP-activated protein kinase subunit beta-10001
Leukotriene C4 synthase0011
tyrosine-protein kinase Yes1001
Bone morphogenetic protein receptor type-1B0011
Membrane-associated progesterone receptor component 10011
Cell division cycle 7-related protein kinase0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0112
Serine/threonine-protein kinase PLK40112
Serine/threonine-protein kinase 250011
ATP-dependent RNA helicase DDX3X0011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase RIO30011
Dual specificity mitogen-activated protein kinase kinase 70011
Serine/threonine-protein kinase Chk10112
Peripheral plasma membrane protein CASK0011
Aurora kinase A0112
Cyclin-G-associated kinase0011
Serine/threonine-protein kinase DCLK10011
Inhibitor of nuclear factor kappa-B kinase subunit alpha0011
Muscle, skeletal receptor tyrosine-protein kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Mitogen-activated protein kinase 130011
Mitogen-activated protein kinase kinase kinase 130011
Death-associated protein kinase 30011
Mitogen-activated protein kinase kinase kinase 70011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
NUAK family SNF1-like kinase 10112
Dynamin-like 120 kDa protein, mitochondrial0011
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0011
Tyrosine-protein kinase JAK20011
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0011
Serine/threonine-protein kinase PAK 30011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 17B0011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30022
Cyclin-dependent kinase 140011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Serine/threonine-protein kinase OSR10011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40213
Serine/threonine-protein kinase Chk20112
Proto-oncogene tyrosine-protein kinase Src0101
Epidermal growth factor receptor0112
RAF proto-oncogene serine/threonine-protein kinase0112
Receptor tyrosine-protein kinase erbB-20011
High affinity nerve growth factor receptor0011
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20011
Mast/stem cell growth factor receptor Kit0101
Platelet-derived growth factor receptor beta0101
Protein kinase C beta type0123
Insulin receptor0112
Tyrosine-protein kinase Lck0112
Tyrosine-protein kinase Fyn0011
Cyclin-dependent kinase 10011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Macrophage colony-stimulating factor 1 receptor0112
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0112
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0112
Tyrosine-protein kinase HCK0112
Proto-oncogene tyrosine-protein kinase ROS0011
Platelet-derived growth factor receptor beta0314
Tyrosine-protein kinase Fgr0011
Wee1-like protein kinase 20011
Uncharacterized serine/threonine-protein kinase SBK30011
Serine/threonine-protein kinase A-Raf0011
Mast/stem cell growth factor receptor Kit0314
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10112
DNA topoisomerase 2-alpha0011
Aromatase0101
Myosin light chain kinase, smooth muscle0011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0112
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Insulin receptor-related protein0011
Serine/threonine-protein kinase B-raf0011
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Platelet-derived growth factor receptor alpha0213
Translocator protein0101
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0123
cAMP-dependent protein kinase catalytic subunit alpha0011
Vascular endothelial growth factor receptor 1 0213
General transcription and DNA repair factor IIH helicase subunit XPD0011
Interferon-induced, double-stranded RNA-activated protein kinase0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Serine/threonine-protein kinase MAK0011
Cyclin-dependent kinase 11B0011
Beta-adrenergic receptor kinase 10101
Ephrin type-A receptor 10011
Fibroblast growth factor receptor 20011
Receptor tyrosine-protein kinase erbB-30011
Multifunctional protein ADE20011
Fibroblast growth factor receptor 40011
Fibroblast growth factor receptor 30011
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Protein kinase C eta type0022
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Platelet-derived growth factor receptor alpha 0101
Activin receptor type-2A0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10112
Ephrin type-A receptor 20011
Ephrin type-A receptor 30011
Ephrin type-A receptor 80011
Ephrin type-B receptor 20011
Leukocyte tyrosine kinase receptor0011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
Tyrosine-protein kinase receptor UFO0112
Mitogen-activated protein kinase 40011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0112
RAC-beta serine/threonine-protein kinase0011
G protein-coupled receptor kinase 40011
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
G protein-coupled receptor kinase 50101
Myosin-100011
Tyrosine-protein kinase receptor Tie-10011
Vascular endothelial growth factor receptor 30213
Vascular endothelial growth factor receptor 20314
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30113
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0022
Exosome RNA helicase MTR40011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0112
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0112
Megakaryocyte-associated tyrosine-protein kinase0011
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase TXK0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase ZAP-700011
Tyrosine-protein kinase SYK0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0112
Casein kinase I isoform delta0011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0112
MAP kinase-activated protein kinase 20011
Cyclin-dependent kinase 80011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Tyrosine-protein kinase Blk0011
Interleukin-1 receptor-associated kinase 10011
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30112
Cytoplasmic tyrosine-protein kinase BMX0011
cAMP-dependent protein kinase catalytic subunit PRKX0011
Serine/threonine-protein kinase Nek20112
Serine/threonine-protein kinase Nek30011
Serine/threonine-protein kinase Nek40011
Tyrosine-protein kinase JAK30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10213
Death-associated protein kinase 10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 120011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40112
Ephrin type-B receptor 10011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Hormonally up-regulated neu tumor-associated kinase0011
Serine/threonine-protein kinase SIK10011
Receptor-interacting serine/threonine-protein kinase 40011
Ras-related protein Rab-100011
Cell division control protein 2 homolog0011
Actin-related protein 30011
Actin-related protein 20011
Calcium-dependent protein kinase 10011
GTP-binding nuclear protein Ran0011
Tubulin alpha-1A chain0011
Casein kinase II subunit alpha0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0011
SRSF protein kinase 20011
Casein kinase I isoform gamma-20011
DNA-dependent protein kinase catalytic subunit0101
Mitogen-activated protein kinase kinase kinase 90011
Protein delta homolog 10112
Serine/threonine-protein kinase PknB0011
Cyclin-dependent kinase 30011
Cyclin-dependent kinase-like 10011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
ATP-dependent 6-phosphofructokinase, platelet type0011
Protein kinase C epsilon type0123
Dual specificity mitogen-activated protein kinase kinase 10011
Angiopoietin-1 receptor0112
Mitogen-activated protein kinase kinase kinase 100011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0022
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10112
Protein kinase C zeta type0022
Protein kinase C delta type0123
Tyrosine-protein kinase BTK0011
Tyrosine-protein kinase receptor TYRO30011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Tyrosine-protein kinase ITK/TSK0011
Myotonin-protein kinase0011
Mitogen-activated protein kinase kinase kinase kinase 20011
Mitogen-activated protein kinase kinase kinase 120011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
Serine/threonine-protein kinase PAK 10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
cGMP-dependent protein kinase 20011
Integrin-linked protein kinase0011
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Serine/threonine-protein kinase PRP4 homolog0011
Serine/threonine-protein kinase ATR0011
Receptor-interacting serine/threonine-protein kinase 10011
Calcium/calmodulin-dependent protein kinase type II subunit beta0011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Calcium/calmodulin-dependent protein kinase type 10011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Sodium channel protein type 5 subunit alpha0101
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Cyclin-dependent kinase 100011
Serine/threonine-protein kinase D10022
Serine/threonine-protein kinase 380011
Receptor tyrosine-protein kinase erbB-40011
Ribosomal protein S6 kinase alpha-20011
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10112
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Rhodopsin kinase GRK10011
NT-3 growth factor receptor0011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
BDNF/NT-3 growth factors receptor0011
Mitogen-activated protein kinase 60011
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10112
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Serine/threonine-protein kinase ULK30011
Serine/threonine-protein kinase SBK10011
Mitogen-activated protein kinase kinase kinase 190011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase TNNI3K0011
Rab-like protein 30011
Leucine-rich repeat serine/threonine-protein kinase 20112
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Serine/threonine-protein kinase Nek50011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Dual serine/threonine and tyrosine protein kinase0011
Mitogen-activated protein kinase kinase kinase 150011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Serine/threonine-protein kinase tousled-like 20011
Serine/threonine-protein kinase 32C0011
Serine/threonine-protein kinase pim-30011
ATP-dependent RNA helicase DDX420011
Serine/threonine-protein kinase VRK20011
Myosin light chain kinase family member 40011
Homeodomain-interacting protein kinase 10011
Calcium/calmodulin-dependent protein kinase type 1D0011
Mitogen-activated protein kinase kinase kinase kinase 30011
Cyclin-dependent kinase-like 30011
MAP kinase-activated protein kinase 50011
Serine/threonine-protein kinase BRSK20011
NAD-dependent protein deacetylase sirtuin-20101
Serine/threonine-protein kinase NIM10011
Serine/threonine-protein kinase ULK20011
Misshapen-like kinase 10011
Serine/threonine-protein kinase DCLK20011
Calcium/calmodulin-dependent protein kinase kinase 10011
Casein kinase I isoform alpha-like0011
Homeodomain-interacting protein kinase 40011
Myosin-IIIa0011
Ankyrin repeat and protein kinase domain-containing protein 10011
Serine/threonine-protein kinase Nek110011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
Serine/threonine-protein kinase BRSK10011
Serine/threonine-protein kinase 350011
Serine/threonine-protein kinase Nek70011
Rhodopsin kinase GRK70011
Serine/threonine-protein kinase 32A0011
Myosin-IIIb0011
ATP-dependent RNA helicase DDX10011
Dual specificity tyrosine-phosphorylation-regulated kinase 20011
Cyclin-dependent kinase-like 20011
Mitogen-activated protein kinase kinase kinase kinase 10011
Serine/threonine-protein kinase Sgk30011
Atypical kinase COQ8B, mitochondrial0011
Aurora kinase B0112
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
Cyclin-dependent kinase 150011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
SRSF protein kinase 10011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Serine/threonine-protein kinase RIO10011
MAP kinase-interacting serine/threonine-protein kinase 10011
Serine/threonine-protein kinase RIO20011
Cyclin-dependent kinase 190011
Transient receptor potential cation channel subfamily M member 60011
Testis-specific serine/threonine-protein kinase 10011
Serine/threonine-protein kinase 330011
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
Serine/threonine-protein kinase DCLK30011
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
Myosin light chain kinase 2, skeletal/cardiac muscle0011
STE20-like serine/threonine-protein kinase 0011
Poly [ADP-ribose] polymerase tankyrase-20011
Serine/threonine-protein kinase TAO30011
Homeodomain-interacting protein kinase 20011
Tyrosine-protein kinase Srms0011
Homeodomain-interacting protein kinase 30011
Serine/threonine-protein kinase PLK30112
dCTP pyrophosphatase 10011
Bromodomain-containing protein 90011
Dual specificity protein kinase CLK40011
MAP kinase-interacting serine/threonine-protein kinase 20011
Serine/threonine-protein kinase Nek60011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase 30011
Bromodomain-containing protein 70011
Serine/threonine-protein kinase PAK 60112
SNF-related serine/threonine-protein kinase0011
Serine/threonine-protein kinase LATS20011
Serine/threonine-protein kinase 360011
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Serine/threonine-protein kinase 32B0011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase PLK20112
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase MARK10011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase PAK 50112
Serine/threonine-protein kinase 260011
eIF-2-alpha kinase GCN20011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
Phosphatidylinositol 4-kinase beta0011
Serine/threonine-protein kinase 17A0011
STE20/SPS1-related proline-alanine-rich protein kinase0011
Ephrin type-A receptor 60011
Serine/threonine-protein kinase TBK10112
Septin-90011
Death-associated protein kinase 20011
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase tousled-like 10011
Serine/threonine-protein kinase TAO20011
Long-chain-fatty-acid--CoA ligase 50011
ALK tyrosine kinase receptor0112
SRSF protein kinase 30011
Serine/threonine-protein kinase ICK0011
Cyclin-dependent kinase 11A0011
Aurora kinase C0011
Calcium/calmodulin-dependent protein kinase type II subunit alpha0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase 38-like0011
Microtubule-associated serine/threonine-protein kinase 10011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
Carbonic anhydrase 30101
Cystine/glutamate transporter0101
Nuclear receptor subfamily 1 group I member 20011
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Protein kinase C gamma type0112
Luciferin 4-monooxygenase0011
Beta-1 adrenergic receptor0101
Ras guanyl-releasing protein 30011
Cereblon isoform 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain A, Nuclear Receptor ROR-beta0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Parkin1001
Ornithine decarboxylase0001
60 kDa chaperonin0101
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
procathepsin L isoform 1 preproprotein0101
Rap guanine nucleotide exchange factor 31001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]