| Assay ID | Title | Year | Journal | Article |
|---|
| AID1234208 | Antiviral activity against coxsackievirus B3 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect at maximal nontoxic concentration dosed 1 hr after viral adsorption | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7
| Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis. |
| AID1278838 | Antiproliferative activity against human MCF7 cells after 3 days by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
| Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines. |
| AID1242262 | Immunoregulatory activity in BALC/c mouse assessed as reduction in B cells at 60 mg/kg, ip once daily for 8 days by flow cytometry | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17
| Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. |
| AID1242260 | Immunoregulatory activity in BALC/c mouse assessed as increase in CD4+ T cells at 60 mg/kg, ip once daily for 8 days by flow cytometry | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17
| Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. |
| AID1387677 | Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBeAg secretion at 0.8 mM supplemented with fresh medium containing compound every 3 days for 9 days measured after 9 days by ELISA relative to control | 2018 | Journal of natural products, 10-26, Volume: 81, Issue:10
| Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus. |
| AID1387681 | Cytotoxicity against human HepG2.2.15 cells assessed as growth inhibition at 1 mM by MTT assay relative to control | 2018 | Journal of natural products, 10-26, Volume: 81, Issue:10
| Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus. |
| AID1242269 | Antiviral activity against human enterovirus 71 infected in ICR mouse assessed as increase in survival rate at 15 mg/kg, ip qd for 8 days dosed 2 hrs post infection and measured at 14 days post infection relative to control | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17
| Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. |
| AID1242264 | Immunoregulatory activity in BALC/c mouse assessed as reduction in NK cells at 60 mg/kg, ip once daily for 8 days by flow cytometry | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17
| Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. |
| AID1234206 | Antiviral activity against influenza A virus (A/Hanfang/359/95(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenic effect dosed 1 hr after viral adsorption | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7
| Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis. |
| AID1278837 | Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
| Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines. |
| AID1234205 | Cytotoxic activity against MDCK cells assessed as cytopathogenic effect incubated for 48 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7
| Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis. |
| AID1242263 | Immunoregulatory activity in BALC/c mouse assessed as reduction in DC cells at 60 mg/kg, ip once daily for 8 days by flow cytometry | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17
| Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. |
| AID1234207 | Selectivity index, ratio of TC50 for African green monkey MDCK cells to IC50 for influenza A virus (A/Hanfang/359/95(H3N2)) | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7
| Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis. |
| AID1278834 | Antiproliferative activity against human A549 cells after 3 days by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
| Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines. |
| AID1387673 | Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBsAg secretion at 0.8 mM supplemented with fresh medium containing compound every 3 days for 9 days measured after 9 days by ELISA relative to control | 2018 | Journal of natural products, 10-26, Volume: 81, Issue:10
| Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus. |
| AID1278835 | Antiproliferative activity against human KB cells after 3 days by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
| Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines. |
| AID1278836 | Antiproliferative activity against human KBVIN cells after 3 days by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
| Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines. |
| AID1242261 | Immunoregulatory activity in BALC/c mouse assessed as increase in CD8+ T cells at 60 mg/kg, ip once daily for 8 days by flow cytometry | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17
| Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. |
| AID1242259 | Immunoregulatory activity in BALC/c mouse assessed as increase in CD3+ T cells at 60 mg/kg, ip once daily for 8 days by flow cytometry | 2015 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17
| Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |