Target type: molecularfunction
Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. [GOC:ai, PMID:2970671]
Laminin receptor activity is a molecular function that describes the ability of a protein to bind to laminin, a major component of the basement membrane. This binding interaction plays a crucial role in a variety of cellular processes, including cell adhesion, migration, and signaling. Laminins are heterotrimeric proteins composed of an alpha, beta, and gamma chain. They are assembled into a complex network that provides structural support and a signaling platform for cells. The interaction between laminin receptors and laminin is mediated by specific domains within both proteins. The laminin receptor typically binds to the globular domain of the laminin alpha chain. This binding event triggers a cascade of intracellular signaling pathways that regulate cell behavior. Laminin receptor activity is essential for the proper development and function of tissues and organs. It is involved in processes such as wound healing, angiogenesis, and tumor metastasis. Dysregulation of laminin receptor activity can contribute to a variety of diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Advanced glycosylation end product-specific receptor | An advanced glycosylation end product-specific receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15109] | Homo sapiens (human) |
| 40S ribosomal protein SA | A eukaryotic-type small ribosomal subunit protein uS2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08865] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| quinolinic acid | pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups. quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan. Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. | pyridinedicarboxylic acid | Escherichia coli metabolite; human metabolite; mouse metabolite; NMDA receptor agonist |
| matrine | alkaloid | ||
| vilazodone | vilazodone : A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder. | 1-benzofurans; indoles; monocarboxylic acid amide; N-alkylpiperazine; N-arylpiperazine; nitrile | antidepressant; serotonergic agonist; serotonin uptake inhibitor |
| gentamicin sulfate | |||
| fps-zm1 | FPS-ZM1: a neuroprotective agent and RAGE receptor antagonist; structure in first source | ||
| PF-06446846 | PF-06446846 : A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. PF-06446846: inhibits translation of PCSK9 ;structure in first source | benzamides; monochloropyridine; piperidines; tertiary carboxamide; triazolopyridine | antilipemic drug; EC 3.4.21.61 (kexin) inhibitor |
| n(delta)-(5-methyl-4-oxo-2-imidazolin-2-yl)ornithine | N(delta)-(5-methyl-4-oxo-2-imidazolin-2-yl)ornithine: RN given for (L)-isomer; structure in first source |