losartan has been researched along with Leukostasis in 3 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Leukostasis: Abnormal intravascular leukocyte aggregation and clumping often seen in leukemia patients. The brain and lungs are the two most commonly affected organs. This acute syndrome requires aggressive cytoreductive modalities including chemotherapy and/or leukophoresis. It is differentiated from LEUKEMIC INFILTRATION which is a neoplastic process where leukemic cells invade organs.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Captopril and losartan also inhibited hyperglycemia-induced leukostasis at 6 weeks and 1 week in the retinal vasculature, respectively." | 7.74 | Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy. ( Gao, L; Kern, TS; Xi, X; Zhang, JZ, 2007) |
| "To study if the endogenous renin-angiotensin system affects diabetic retinal leukostasis, rats with streptozotocin-induced diabetes were treated with an ACE inhibitor (ramipril), an angiotensin II AT(1) receptor antagonist (losartan) and the Ca channel blocker, (nifedipine)." | 7.73 | Role of angiotensin II in retinal leukostasis in the diabetic rat. ( Chen, P; Dahl, D; Edwards, PA; Fenstermacher, JD; Guo, M; Scicli, AG; Scicli, GM, 2006) |
| "We studied whether angiotensin II (ANG II) via superoxide may contribute to retinal leukostasis and thus to the pathogenesis of retinopathies." | 3.74 | Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. ( Chen, P; Edwards, PA; Guo, AM; Scicli, AG; Trick, G, 2007) |
| " Captopril and losartan also inhibited hyperglycemia-induced leukostasis at 6 weeks and 1 week in the retinal vasculature, respectively." | 3.74 | Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy. ( Gao, L; Kern, TS; Xi, X; Zhang, JZ, 2007) |
| "To study if the endogenous renin-angiotensin system affects diabetic retinal leukostasis, rats with streptozotocin-induced diabetes were treated with an ACE inhibitor (ramipril), an angiotensin II AT(1) receptor antagonist (losartan) and the Ca channel blocker, (nifedipine)." | 3.73 | Role of angiotensin II in retinal leukostasis in the diabetic rat. ( Chen, P; Dahl, D; Edwards, PA; Fenstermacher, JD; Guo, M; Scicli, AG; Scicli, GM, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, P | 2 |
| Scicli, GM | 1 |
| Guo, M | 1 |
| Fenstermacher, JD | 1 |
| Dahl, D | 1 |
| Edwards, PA | 2 |
| Scicli, AG | 2 |
| Guo, AM | 1 |
| Trick, G | 1 |
| Zhang, JZ | 1 |
| Xi, X | 1 |
| Gao, L | 1 |
| Kern, TS | 1 |
3 other studies available for losartan and Leukostasis
| Article | Year |
|---|---|
Role of angiotensin II in retinal leukostasis in the diabetic rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; A | 2006 |
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis.
Topics: Acetophenones; Acetylcysteine; Angiogenesis Inhibitors; Angiotensin II; Angiotensin II Type 1 Recept | 2007 |
Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; A | 2007 |