3-hydroxybutyric acid has been researched along with Cockayne Syndrome in 1 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Cockayne Syndrome: A syndrome characterized by multiple system abnormalities including DWARFISM; PHOTOSENSITIVITY DISORDERS; PREMATURE AGING; and HEARING LOSS. It is caused by mutations of a number of autosomal recessive genes encoding proteins that involve transcriptional-coupled DNA REPAIR processes. Cockayne syndrome is classified by the severity and age of onset. Type I (classical; CSA) is early childhood onset in the second year of life; type II (congenital; CSB) is early onset at birth with severe symptoms; type III (xeroderma pigmentosum; XP) is late childhood onset with mild symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Furthermore, premature aging in CS mice, nematodes, and human cells results from aberrant PARP activation due to deficient DNA repair leading to decreased SIRT1 activity and mitochondrial dysfunction." | 5.40 | A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. ( Bergersen, LH; Bohr, VA; Cogger, VC; Croteau, DL; de Cabo, R; Dunn, CA; Fang, EF; Hasan-Olive, MM; Iyama, T; Le Couteur, DG; Mangerich, A; Mattson, MP; Mitchell, SJ; Moaddel, R; Scheibye-Knudsen, M; Singh, N; Veith, S; Wang, J; Ward, T; Warren, A; Wilson, DM; Wilson, MA, 2014) |
| "Furthermore, premature aging in CS mice, nematodes, and human cells results from aberrant PARP activation due to deficient DNA repair leading to decreased SIRT1 activity and mitochondrial dysfunction." | 1.40 | A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. ( Bergersen, LH; Bohr, VA; Cogger, VC; Croteau, DL; de Cabo, R; Dunn, CA; Fang, EF; Hasan-Olive, MM; Iyama, T; Le Couteur, DG; Mangerich, A; Mattson, MP; Mitchell, SJ; Moaddel, R; Scheibye-Knudsen, M; Singh, N; Veith, S; Wang, J; Ward, T; Warren, A; Wilson, DM; Wilson, MA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scheibye-Knudsen, M | 1 |
| Mitchell, SJ | 1 |
| Fang, EF | 1 |
| Iyama, T | 1 |
| Ward, T | 1 |
| Wang, J | 1 |
| Dunn, CA | 1 |
| Singh, N | 1 |
| Veith, S | 1 |
| Hasan-Olive, MM | 1 |
| Mangerich, A | 1 |
| Wilson, MA | 1 |
| Mattson, MP | 1 |
| Bergersen, LH | 1 |
| Cogger, VC | 1 |
| Warren, A | 1 |
| Le Couteur, DG | 1 |
| Moaddel, R | 1 |
| Wilson, DM | 1 |
| Croteau, DL | 1 |
| de Cabo, R | 1 |
| Bohr, VA | 1 |
1 other study available for 3-hydroxybutyric acid and Cockayne Syndrome
| Article | Year |
|---|---|
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Topics: 3-Hydroxybutyric Acid; Aging, Premature; Animals; Cell Line; Cockayne Syndrome; Diet, High-Fat; Enzy | 2014 |