amitriptyline has been researched along with Cockayne Syndrome in 1 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Cockayne Syndrome: A syndrome characterized by multiple system abnormalities including DWARFISM; PHOTOSENSITIVITY DISORDERS; PREMATURE AGING; and HEARING LOSS. It is caused by mutations of a number of autosomal recessive genes encoding proteins that involve transcriptional-coupled DNA REPAIR processes. Cockayne syndrome is classified by the severity and age of onset. Type I (classical; CSA) is early childhood onset in the second year of life; type II (congenital; CSB) is early onset at birth with severe symptoms; type III (xeroderma pigmentosum; XP) is late childhood onset with mild symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted to bypass its function by expressing downstream target genes." | 1.43 | Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation. ( Chakravarty, P; Jones-Tabah, J; Laposa, RR; Muotri, A; Stewart, A; Svejstrup, JQ; Wang, Y, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Jones-Tabah, J | 1 |
| Chakravarty, P | 1 |
| Stewart, A | 1 |
| Muotri, A | 1 |
| Laposa, RR | 1 |
| Svejstrup, JQ | 1 |
1 other study available for amitriptyline and Cockayne Syndrome
| Article | Year |
|---|---|
Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation.
Topics: Amitriptyline; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Line, Tumor; Chromatin | 2016 |