mitomycin has been researched along with Cockayne Syndrome in 3 studies
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.
Cockayne Syndrome: A syndrome characterized by multiple system abnormalities including DWARFISM; PHOTOSENSITIVITY DISORDERS; PREMATURE AGING; and HEARING LOSS. It is caused by mutations of a number of autosomal recessive genes encoding proteins that involve transcriptional-coupled DNA REPAIR processes. Cockayne syndrome is classified by the severity and age of onset. Type I (classical; CSA) is early childhood onset in the second year of life; type II (congenital; CSB) is early onset at birth with severe symptoms; type III (xeroderma pigmentosum; XP) is late childhood onset with mild symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "By comparing fibroblast strains derived from individuals exhibiting chromosome instability and/or mutagen hypersensitivity (Cockayne syndrome, ataxia telangiectasia, and Fanconi anemia) with strains derived from healthy donors, the fibroblast micronucleus assay has been established as a reproducible measure of the genotypic variation in spontaneous or mitomycin C (MMC)-induced chromosomal instability." | 3.67 | Micronucleus assay in human fibroblasts: a measure of spontaneous chromosomal instability and mutagen hypersensitivity. ( Dimnik, LS; Greentree, CL; Hennig, UG; Hoar, DI; Rudd, NL, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, K | 1 |
| Wada, K | 1 |
| Matsumoto, K | 1 |
| Moriya, M | 1 |
| Andera, L | 1 |
| Wasylyk, B | 1 |
| Rudd, NL | 1 |
| Hoar, DI | 1 |
| Greentree, CL | 1 |
| Dimnik, LS | 1 |
| Hennig, UG | 1 |
3 other studies available for mitomycin and Cockayne Syndrome
| Article | Year |
|---|---|
Physical interaction between SLX4 (FANCP) and XPF (FANCQ) proteins and biological consequences of interaction-defective missense mutations.
Topics: Amino Acid Sequence; Animals; Chromosome Aberrations; Cockayne Syndrome; DNA Repair; DNA-Binding Pro | 2015 |
Transcription abnormalities potentiate apoptosis of normal human fibroblasts.
Topics: Amanitins; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Survival; Cells, Cultured; Cisplatin; | 1997 |
Micronucleus assay in human fibroblasts: a measure of spontaneous chromosomal instability and mutagen hypersensitivity.
Topics: Adult; Anemia, Aplastic; Ataxia Telangiectasia; Cell Nucleus; Cells, Cultured; Chromosomes; Cockayne | 1988 |