1-(2-chlorobenzoyl)-3-(4-chlorophenyl)urea profile

1-(2-chlorobenzoyl)-3-(4-chlorophenyl)urea, also known as **chlorobenzoylurea**, is a chemical compound that has been studied for its potential biological activities.

**Structure and Properties:**

* **Chemical formula:** C14H10Cl2N2O2
* **Molecular weight:** 309.13 g/mol
* **Appearance:** White to off-white solid
* **Solubility:** Soluble in organic solvents like methanol and ethanol

**Importance for Research:**

Chlorobenzoylurea has attracted research interest for several reasons:

* **Potential Anti-Cancer Activity:**
* Studies have shown that this compound exhibits cytotoxic effects against certain cancer cell lines.
* Its mechanism of action might involve inhibiting the growth and proliferation of cancer cells.
* **Insecticidal Activity:**
* Chlorobenzoylurea possesses insecticidal properties, particularly against some insect pests.
* It may disrupt the chitin synthesis in insects, affecting their growth and development.
* **Antimicrobial Activity:**
* Preliminary research suggests that chlorobenzoylurea may possess antimicrobial activity against certain bacteria and fungi.
* **Anti-inflammatory Activity:**
* Some studies have indicated that this compound might exhibit anti-inflammatory effects.

**Research Status and Challenges:**

* While initial research shows promise, further studies are needed to fully understand the biological activity of chlorobenzoylurea and its potential therapeutic applications.
* **Safety concerns:** Further research is required to determine the safety profile and potential toxicity of chlorobenzoylurea, especially for its potential use as a drug.
* **Drug development:** Optimization of the structure and properties of chlorobenzoylurea might be necessary to enhance its potency, selectivity, and pharmacokinetic profile for drug development purposes.

**Overall:**

Chlorobenzoylurea is a chemical compound with potential biological activities, including anti-cancer, insecticidal, antimicrobial, and anti-inflammatory properties. However, further research is necessary to fully understand its mechanisms of action, safety profile, and therapeutic potential.

1-(2-chlorobenzoyl)-3-(4-chlorophenyl)urea: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	108078
CHEMBL ID	2251413
SCHEMBL ID	5177776
MeSH ID	M0479849

Synonym
LS-14266
2-chloro-n-(((4-chlorophenyl)amino)carbonyl)benzamide
FT-0657331
2-chloro-n-[(4-chlorophenyl)carbamoyl]benzamide
A831333
57160-47-1
chlorobenzuron
benzamide, 2-chloro-n-(((4-chlorophenyl)amino)carbonyl)-
AKOS015895570
CHEMBL2251413
chlorbenzuron
SCHEMBL5177776
1-(2-chlorobenzoyl)-3-(4-chlorophenyl)urea
DTXSID00205795
AT25519
chlorobenzuron 10 microg/ml in acetonitrile
benzamide, 2-chloro-n-[[(4-chlorophenyl)amino]carbonyl]-
HY-B2063
2-chloro-n-((4-chlorophenyl)carbamoyl)benzamide
CS-0014155
chlorobenzuron 1000 microg/ml in acetone
mfcd08273838

Excerpt	Reference	Relevance
" In this paper we describe a simple, rapid, and convenient prediction model for predicting the level and time of occurrence of the peak concentration of 2-chlorobenzamide in the hydrolysis of CCU verified by experimental data."	( Calculation of the peak concentration of 2-chlorobenzamide generated in the hydrolysis of the benzoylphenylurea insecticide 1-(2-chlorobenzoyl)-3-(4-chlorophenyl)urea. Liu, G; Lu, W; Zhou, Q, 2004)	0.53

Assay ID	Title	Year	Journal	Article
AID1091642	Larvicidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 25 +/-1 degC after 4 days	2008	Journal of agricultural and food chemistry, Dec-10, Volume: 56, Issue:23	Design, synthesis, bioactivity, and structure-activity relationship (SAR) studies of novel benzoylphenylureas containing oxime ether group.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	3 (37.50)	24.3611
2020's	2 (25.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	7.44	2	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
cypermethrin cypermethrin : A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.. zeta-cypermethrin : A diastereoisomeric mixture comprising the isomeric pair (1R)-cis-(alphaS)- and (1S)-trans-(alphaR)-cypermethrin together with the isomeric pair (1S)-cis-(alphaS)- and (1S)-trans-(alphaS)-cypermethrin where the ratio between the isomeric pairs lies in the range 45:55 to 55:45.	2.41	1	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound	agrochemical; molluscicide; pyrethroid ester acaricide; pyrethroid ester insecticide
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2.11	1	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
tetrachloroisophthalonitrile tetrachloroisophthalonitrile: structure. chlorothalonil : A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops.	2.41	1	aromatic fungicide; dinitrile; tetrachlorobenzene	antifungal agrochemical
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	2.11	1	diatomic chlorine; gas molecular entity	bleaching agent
chlortoluron chlorotoluron : A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by two methyl groups while the other is substituted by a 3-chloro-4-methylphenyl group. A herbicide that is non-toxic to honeybees but moderately toxic to mammals, birds, earthworms and most aquatic organisms.	2.05	1	monochlorobenzenes; phenylureas	agrochemical; environmental contaminant; herbicide; xenobiotic
diflubenzuron Diflubenzuron: An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.. diflubenzuron : A benzoylurea insecticide that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 4-chlorophenyl group, and a hydrogen attached to the other nitrogen is replaced bgy a 2,6-difluorobenzoyl group.	2.11	1	benzoylurea insecticide; monochlorobenzenes	insect sterilant
pendimethalin pendimethalin : A member of the class of substituted anilines that is N-(pentan-3-yl)aniline bearing two additional nitro substituents at positions 2 and 6 as well as two methyl substituents at positions 3 and 4. A herbicide used to control most annual grasses and many annual broad-leaved weeds.	2.41	1	C-nitro compound; secondary amino compound; substituted aniline	agrochemical; environmental contaminant; herbicide
chlorfluazuron chlorfluazuron: chitin synthesis inhibitor	2.04	1	benzoylurea insecticide; dichlorobenzene; organochlorine insecticide; organofluorine insecticide
teflubenzuron teflubenzuron: effective against development of house fly larvae (Musca domestica). teflubenzuron : A N-acylurea that is N-carbamoyl-2,6-difluorobenzamide substituted by a 3,5-dichloro-2,4-difluorophenyl group at the terminal nitrogen atom.	2.04	1	dichlorobenzene; difluorobenzene; N-acylurea	environmental contaminant; insecticide; xenobiotic
hexafluoron hexafluoron: insect growth regulator against mosquito larva; the active agent in Sonet, a Russian product, is hexaflumuron. hexaflumuron : An N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.	2.04	1	aromatic ether; benzoylurea insecticide; dichlorobenzene; N-acylurea; organochlorine insecticide; organofluorine insecticide
diethofencarb diethofencarb: structure given in first source. diethofencarb : A carbamate ester that is the isopropyl ester of (3,4-diethoxyphenyl)carbamic acid. A fungicide with strong activity against Botrytis cinerea and benzimidazole-resistant strains of Botryis spp.	2.05	1	aromatic ether; carbamate ester; carbanilate fungicide	antifungal agrochemical
flucycloxuron [no description available]	2.04	1	flucycloxuron
pyrethrins [no description available]	2.41	1

1-(2-chlorobenzoyl)-3-(4-chlorophenyl)urea

Description

Cross-References

Synonyms (22)

Research Excerpts

Pharmacokinetics

Bioassays (1)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.51

Study Types