Compounds > n-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide
Page last updated: 2024-11-09

n-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide

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Description

N-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide: activates the plant defense response; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

tiadinil : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid with the amino group of 3-chloro-4-methylaniline. It is a fungicide used particularly for the control of fungal diseases in rice. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID2804318
CHEMBL ID1543783
CHEBI ID81825
SCHEMBL ID21573
MeSH IDM0581374

Synonyms (34)

Synonym
smr000324370
MLS000685855
n-(3-chloro-4-methylphenyl)-4-methylthiadiazole-5-carboxamide
AKOS001528256
C18550
tiadinil
n-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide
STK518167
HMS2773B22
F2630-0119
223580-51-6
HY-17517
CS-3303
SCHEMBL21573
CHEMBL1543783
chebi:81825 ,
3'-chloro-4,4'-dimethyl-1,2,3-thiadiazole-5-carboxanilide
DTXSID9058024
mfcd00113740
tiadinil 100 microg/ml in acetonitrile
FT-0733676
Z89295866
Q19310041
BCP33322
AS-56042
tiadinil [iso]
1,2,3-thiadiazole-5-carboxamide, n-(3-chloro-4-methylphenyl)-4-methyl-
saixianjunan
v-get
T89DDV3BQZ ,
tiadinil [mi]
A878573
unii-t89ddv3bqz
EN300-6743228
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
antifungal agrochemicalAny substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
monocarboxylic acid amideA carboxamide derived from a monocarboxylic acid.
monochlorobenzenesAny member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine.
thiadiazoles
organosulfur compoundAn organosulfur compound is a compound containing at least one carbon-sulfur bond.
anilide fungicideAny amide fungicide whose structure contains an anilide group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
ATAD5 protein, partialHomo sapiens (human)Potency23.09990.004110.890331.5287AID504467
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency10.32250.00419.984825.9290AID504444
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency70.79460.050127.073689.1251AID588590
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency0.35480.025911.239831.6228AID602313
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (77)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1081560Fungicidal activity against Fusarium graminearum at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1640018Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent 2018Science (New York, N.Y.), 12-07, Volume: 362, Issue:6419
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
AID1081200Antiviral activity against Tobacco mosaic virus (TMV) infected leaves assessed as viral inhibition at 100 ug/mL at 25 degC for 72 hr2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis, crystal structure, and biological activity of 4-methyl-1,2,3-thiadiazole-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
AID1081542Induction of systemic acquired resistance activity in TMV infected-Nicotiana tabacum (tobacco) leaves at 50 ug/ml2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1091989Antifungal activity against Puccinia triticina inoculated on 500 ug/mL compound pre-treated wheat plants with 3 to 5 leaves assessed as growth inhibition2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081555Fungicidal activity against Puccinia triticina at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1092014Induction of systemic acquired resistance against Tobacco mosaic virus (TMV) in tobacco plants exposed to 500 ug/mL compound through irrigation based soil treatment followed by 7 days culture under green house conditions assessed as inhibition of viral gr2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081161In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as protective effect at 100 ug/ml treated 12 hr before viral inoculation measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1640019Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent 2018Science (New York, N.Y.), 12-07, Volume: 362, Issue:6419
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
AID1091995Antifungal activity against Alternaria solani assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081548In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as curative effect at 500 ug/ml treated after viral inoculation measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081545In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as inactivation effect at 100 ug/ml co-treated with virus for 30 min before inoculation onto leaves measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081543Phytotoxicity against Nicotiana tabacum (tobacco) plant2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1092001Antifungal activity against Alternaria mali assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081564Fungicidal activity against Alternaria solani at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1091993Antifungal activity against Phytophthora infestans assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1091994Antifungal activity against Rhizoctonia solani assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081557Fungicidal activity against Botryosphaeria berengeriana at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081156Induction of systemic acquired resistance activity in TMV infected-Nicotiana tabacum (tobacco) leaves at 100 ug/ml2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1092009Antifungal activity against Fusarium fujikuroi assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1092002Antifungal activity against Sclerotinia sclerotiorum assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081565Fungicidal activity against Botryotinia fuckeliana at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081554Fungicidal activity against Rhizoctonia solani at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081162In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as protective effect at 500 ug/ml treated 12 hr before viral inoculation measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1081160In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as curative effect at 500 ug/ml treated after viral inoculation measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1081563Fungicidal activity against Mycosphaerella arachidis at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081163In vitro antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves at 100 ug/ml2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1081553In vitro antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves at 500 ug/ml2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081157In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as inactivation effect at 100 ug/ml co-treated with virus for 30 min before inoculation onto leaves measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1081561Fungicidal activity against Colletotrichum lagenaria at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081547In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as curative effect at 100 ug/ml treated after viral inoculation measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081202Antiviral activity against Tobacco mosaic virus (TMV) infected leaves assessed as viral inhibition at 500 ug/mL at 25 degC for 72 hr2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis, crystal structure, and biological activity of 4-methyl-1,2,3-thiadiazole-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
AID1092020Induction of systemic acquired resistance against Tobacco mosaic virus (TMV) in tobacco plants exposed to 500 ug/mL compound through leaf spray followed by 7 days culture under green house conditions assessed as inhibition of viral growth in leaves infect2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1092004Antifungal activity against Villosiclava virens assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081159In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as curative effect at 100 ug/ml treated after viral inoculation measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1091996Antifungal activity against Fusarium oxysporum f. sp. vasinfectum assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081199Induction of systemic acquired resistance in Nicotiana tabacum (tobacco) mosaic virus infected Nicotiana tabacum (tobacco) plant at 100 ug/mL at 25 degC for 72 hr2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis, crystal structure, and biological activity of 4-methyl-1,2,3-thiadiazole-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
AID1091999Antifungal activity against Colletotrichum lagenaria assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1092029In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves exposed to 500 ug/mL for 20 min assessed as inhibition of viral growth measured 72 hr post compound treatment compound by half-leaf juice rubbing method2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1092031Antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves exposed to 500 ug/mL for 20 min assessed as inhibition of viral growth measured 72 hr post compound treatment compound by half-leaf juice rubbing method2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081158In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as inactivation effect at 500 ug/ml co-treated with virus for 30 min before inoculation onto leaves measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1081556Fungicidal activity against Thanatephorus cucumeris at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1091991Antifungal activity against Ceratobasidium cereale assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081562Fungicidal activity against Cercospora beticola at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1092005Antifungal activity against Fusarium graminearum assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081550In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as protective effect at 500 ug/ml treated 12 hr before viral inoculation measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1092008Antifungal activity against Fusarium oxysporum assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081155Induction of systemic acquired resistance activity in TMV infected-Nicotiana tabacum (tobacco) leaves at 50 ug/ml2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1081546In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as inactivation effect at 500 ug/ml co-treated with virus for 30 min before inoculation onto leaves measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1092007Antifungal activity against Mycosphaerella arachidis assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081559Fungicidal activity against Fusarium oxysporum at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1092003Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1091992Antifungal activity against Botryosphaeria berengeriana assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1091997Antifungal activity against Alternaria kikuchiana assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1092000Antifungal activity against Valsa mali assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1092006Antifungal activity against Phomopsis asparagi assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081558Fungicidal activity against Phytophthora infestans at 50 ug/ml by growth inhibition method2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081551In vitro antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves at 100 ug/ml2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081544Induction of systemic acquired resistance activity in TMV infected-Nicotiana tabacum (tobacco) leaves at 100 ug/ml2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1081549In vivo antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves assessed as protective effect at 100 ug/ml treated 12 hr before viral inoculation measured at 2-3 days after viral challenge2010Journal of agricultural and food chemistry, Jul-14, Volume: 58, Issue:13
5-Methyl-1,2,3-thiadiazoles synthesized via ugi reaction and their fungicidal and antiviral activities.
AID1092018Induction of systemic acquired resistance against Tobacco mosaic virus (TMV) in tobacco plants exposed to 50 ug/mL compound through leaf spray followed by 7 days culture under green house conditions assessed as inhibition of viral growth in leaves infecte2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
AID1081201Antiviral activity against Tobacco mosaic virus (TMV) infected leaves assessed as viral inhibition at 50 ug/mL at 25 degC for 72 hr2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis, crystal structure, and biological activity of 4-methyl-1,2,3-thiadiazole-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
AID1081164In vitro antiviral activity against Tobacco mosaic virus (TMV) infected tobacco leaves at 500 ug/ml2010Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5
Synthesis of 4-methyl-1,2,3-thiadiazole derivatives via Ugi reaction and their biological activities.
AID1091998Antifungal activity against Glomerella cingulata assessed as growth inhibition at 50 ug/mL measured after 2 days post dose2009Journal of agricultural and food chemistry, May-27, Volume: 57, Issue:10
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's8 (72.73)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.81

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.81 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.81)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acridone
acridone : A member of the class of acridines that is 9,10-dihydroacridine substituted by an oxo group at position 9.		2.1710acridines;
cyclic ketone
ethacridine
Ethacridine: A topically applied anti-infective agent.		2.1710acridines
amiodarone
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.. amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.		2.17101-benzofurans;
aromatic ketone;
organoiodine compound;
tertiary amino compound		cardiovascular drug
ym 58483
[no description available]		2.1710
camphor, (+-)-isomer
[no description available]		2.1710bornane monoterpenoid;
cyclic monoterpene ketone		plant metabolite
carbonyl cyanide m-chlorophenyl hydrazone
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.		2.1710hydrazone;
monochlorobenzenes;
nitrile		antibacterial agent;
geroprotector;
ionophore
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone: A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.. carbonyl cyanide p-trifluoromethoxyphenylhydrazone : A hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group.		2.1710aromatic ether;
hydrazone;
nitrile;
organofluorine compound		ATP synthase inhibitor;
geroprotector;
ionophore
papaverine
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.		2.1710benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
pimobendan
pimobendan: produces arterial & venous dilatation in dogs; structure given in first source		2.1710benzimidazoles;
pyridazinone		cardiotonic drug;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
terfenadine
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.		2.1710diarylmethane
n-isopropyl-n-phenyl-4-phenylenediamine
N-isopropyl-N'-phenyl-p-phenylenediamine : The N-substituted diamine that is 1,4-phenylenediamine substituted at one N with an isopropyl group and at the other with a phenyl group.		2.1710N-substituted diamineallergen;
antioxidant
3-amino-9-ethylcarbazole
3-amino-9-ethylcarbazole: RN given refers to parent cpd		2.1710carbazoles
cycloguanil
cycloguanil: the active metabolite of proguanil; antifolate drug; structure in first source. cycloguanil : A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil.		2.1710triazinesantifolate;
antiinfective agent;
antimalarial;
antiparasitic agent;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
thiazoles
[no description available]		2.05101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
3-aminobutyric acid
3-aminobutyric acid: GABA uptake inhibitor. 3-aminobutanoic acid : A beta-amino acid that is butyric acid which is substituted by an amino group at position 3.		2.0510amino acid zwitterion;
beta-amino acid;
monocarboxylic acid		metabolite
2,4,6-trichlorophenyl 4-nitrophenyl ether
2,4,6-trichlorophenyl 4-nitrophenyl ether: structure		2.1710aromatic ether;
C-nitro compound;
chlorobenzenes		EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
tetrachloroisophthalonitrile
tetrachloroisophthalonitrile: structure. chlorothalonil : A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops.		2.0510aromatic fungicide;
dinitrile;
tetrachlorobenzene		antifungal agrochemical
dioxohexahydrotriazine
[no description available]		2.0510
ribavirin
Rebetron: Rebetron is tradename		2.75301-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
2-phenylthiazolidine-4-carboxylic acid
2-phenylthiazolidine-4-carboxylic acid: RN given refers to cpd without isomeric designation		2.1710
benz(cd)indol-2(1h)-one
benz(cd)indol-2(1H)-one: structure in first source		2.1710
tetraphenylcyclopentadienone
tetraphenylcyclopentadienone: singlet oxygen trapping agent		2.1710stilbenoid
3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine
[no description available]		2.17101,2,4-triazines
honokiol
[no description available]		2.1710biphenyls
bathophenanthroline
4,7-diphenyl-1,10-phenanthroline : A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two phenyl substituents at positions 4 and 7.		2.1710benzenes;
phenanthrolines		chelator
2-phenyl-4,5-dichloro-3-pyridazinone
[no description available]		2.1710
n-benzylmaleimide
[no description available]		2.1710
phenylglycine nitrile
phenylglycine nitrile: structure in first source		2.1710
4,5-dimethyl-1,2-phenylenediamine
4,5-dimethyl-1,2-phenylenediamine: RN given refers to parent cpd		2.1710
s-methyl benzo(1,2,3)thiadiazole-7-carbothioate
S-methyl benzo(1,2,3)thiadiazole-7-carbothioate: induces system acquired resistance in wheat; structure in first source. acibenzolar-S-methyl : A benzothiadiazole that is the S-methyl thioester derivative of acibenzolar. A profungicide (by hydrolysis of the thioester group to give the corresponding carboxylic acid), it is used as a fungicide and plant activator on a variety of crops, including cotton, chili peppers, lettuce, onions, spinach, tobacco, and tomatoes.		2.0510benzothiadiazole;
thioester		antifungal agrochemical;
plant activator;
profungicide
mmv665852
MMV665852: an antischistosomal agent		2.1710
n-(2-methoxyphenyl)maleimide
N-(2-methoxyphenyl)maleimide: structure given in first source		2.1710
2-aminoperimidine
2-aminoperimidine: inhibits bacterial NhaA Na/H+ antiporters; structure in first source		2.1710
1,3-bis(3-chlorophenyl)urea
[no description available]		2.1710ureas
2-phenyl-4-oxohydroquinoline
2-phenyl-4-oxohydroquinoline: structure given in first source		2.1710
2-chloro-3-(4-methylanilino)naphthalene-1,4-dione
[no description available]		2.17101,4-naphthoquinones
mequindox
Mequindox: a synthetic quinoxaline 1,4-dioxide derivative which can effectively improve growth and feed efficiency in animals; structure in first source		2.1710
1,3-bis(3,5-dichlorophenyl)urea
1,3-bis(3,5-dichlorophenyl)urea: COH - City of Hope; has antineoplastic activity		2.1710
dienestrol
Dienestrol: A synthetic, non-steroidal estrogen structurally related to stilbestrol. It is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms.. dienestrol : An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.		2.1710
cinnamoylglycine
cinnamoylglycine: structure given in first source. N-cinnamoylglycine : An N-acylglycine in which the acyl group is specified as (2E)-3-phenylprop-2-enoyl (cinnamoyl).		2.1710N-acylglycinemetabolite
4-(4-ethoxyphenyl)-4-oxobutanoic acid
[no description available]		2.1710aromatic ketone
3-(4-chlorophenyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one
[no description available]		2.1710pyrazoles;
ring assembly
N-[4-[methyl(phenyl)sulfamoyl]phenyl]-2-thiophenecarboxamide
[no description available]		2.1710aromatic amide
4-chloro-N-[3-cyano-4-(phenylthio)phenyl]benzamide
[no description available]		2.1710benzamides
3-(4-morpholinyl)-4-(2-pyridinyl)-N-[3-(trifluoromethyl)phenyl]-1-pyrazolecarboxamide
[no description available]		2.1710pyrazolopyridine
7-chloro-2-methyl-4-(4-methylphenyl)sulfonylthiazolo[5,4-b]indole
[no description available]		2.1710sulfonamide
4-[2-[(2,6-dimethoxyphenyl)-oxomethoxy]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
[no description available]		2.1710methoxybenzoic acid
2-(1H-benzimidazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone
[no description available]		2.1710benzimidazoles
2,3-dihydro-1,4-dioxin-5-carboxylic acid [2-[4-[4-(2-methylbutan-2-yl)phenoxy]anilino]-2-oxoethyl] ester
[no description available]		2.1710aromatic ether
2-(1,3-benzoxazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone
[no description available]		2.1710benzoxazole
3-(4-chlorophenyl)-2-methyl-3,3a,4,5-tetrahydrobenzo[g]indazole
[no description available]		2.1710tetralins
6-hydroxy-4-methyl-2-phenyl-2,3-dihydropyridazin-3-one
[no description available]		2.1710pyridazinone
1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea
1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea : An member of the class of phenylureas that is urea having 4-chlorophenyl and 4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl groups attached at positions 1 and 3 respectively.		2.17101,3-thiazoles;
monochlorobenzenes;
phenylureas;
thiophenes
N'-[(4-chlorophenyl)-oxomethyl]-2-methyl-4-thiazolecarbohydrazide
[no description available]		2.1710carbonyl compound;
organohalogen compound
bi-78d3
[no description available]		2.1710aryl sulfide
N'2-[3-(trifluoromethyl)benzoyl]-3-aminopyrazine-2-carbohydrazide
[no description available]		2.1710(trifluoromethyl)benzenes
2-amino-4-(2-chlorophenyl)-6-[(4-chlorophenyl)thio]pyridine-3,5-dicarbonitrile
[no description available]		2.1710phenylpyridine
2-[5-[(3-chlorophenyl)thio]-2-thiophenyl]pyridine
[no description available]		2.1710aryl sulfide
8-methylsulfinyl-4,5-dihydrothieno[3,4-g][2,1]benzoxazole-6-carboxylic acid ethyl ester
[no description available]		2.1710thiophenecarboxylic acid
1-(5-tert-butyl-2-methyl-3-pyrazolyl)-3-(3,5-dichlorophenyl)urea
[no description available]		2.1710ureas
4-[[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine
[no description available]		2.1710isoquinolines
7-chloro-3-hydroxy-2-[3-(trifluoromethyl)phenyl]-4-quinazolinone
[no description available]		2.1710quinazolines
2-(1H-benzimidazol-2-ylthio)-1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]ethanone
[no description available]		2.1710benzimidazoles
ethyl 4-(3-oxo-2,3-dihydroisothiazol-2-yl)benzoate
[no description available]		2.1710organic molecular entity
7-chloro-N-(phenylmethyl)-4-quinolinamine
[no description available]		2.1710aminoquinoline
6-methoxy-2-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]-4-quinolinamine
[no description available]		2.1710aminoquinoline
2-acetylpyridine thiosemicarbazone
2-acetylpyridine thiosemicarbazone: RN given refers to parent cpd		2.1710
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea: structure in first source		2.1710
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime: a TRPA1 antagonist		2.1710
oxadiazoles
Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Infections, Plasmodium
[description not available]		02.1710
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.1710