| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
choline
[no description available] | 3.62 | 9 | 0 | cholines | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite |
ethanolamine
[no description available] | 2.02 | 1 | 0 | ethanolamines;
primary alcohol;
primary amine | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
diazinon
Diazinon: A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.. diazinon : A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4. | 6.97 | 1 | 0 | organic thiophosphate;
pyrimidines | acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
nematicide;
xenobiotic |
edrophonium
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.. edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. | 1.99 | 1 | 0 | phenols;
quaternary ammonium ion | antidote;
diagnostic agent;
EC 3.1.1.8 (cholinesterase) inhibitor |
n-amino-n,n-dimethylaminoethanol
N-amino-N,N-dimethylaminoethanol: structure given in first source | 1.97 | 1 | 0 | | |
neostigmine
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.. neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor. | 1.99 | 1 | 0 | quaternary ammonium ion | antidote to curare poisoning;
EC 3.1.1.7 (acetylcholinesterase) inhibitor |
vesamicol
vesamicol: RN given refers to parent cpd; structure | 1.99 | 1 | 0 | piperidines | |
physostigmine
Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | 6.97 | 1 | 0 | carbamate ester;
indole alkaloid | antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic |
methylamine
methyl group : An alkyl group that is the univalent group derived from methane by removal of a hydrogen atom. | 1.99 | 1 | 0 | methylamines;
one-carbon compound;
primary aliphatic amine | mouse metabolite |
deanol
Deanol: An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.. N,N-dimethylethanolamine : A tertiary amine that is ethanolamine having two N-methyl substituents. | 2.02 | 1 | 0 | ethanolamines;
tertiary amine | curing agent;
radical scavenger |
n-methylaminoethanol
N-methylaminoethanol: structure. N-methylethanolamine : An ethanolamine compound having an N-methyl substituent. | 2.02 | 1 | 0 | ethanolamines | |
hemicholinium 3
Hemicholinium 3: A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments. | 2.66 | 3 | 0 | | |
1-methylpyridinium
1-methylpyridinium: RN given refers to parent cpd | 2.02 | 1 | 0 | methylpyridines | |
3-quinuclidinol
quinuclidin-3-Ol: structure in first source | 2.02 | 1 | 0 | quinuclidines;
secondary alcohol;
tertiary amine | |
beta-methylcholine
beta-methylcholine: RN given refers to non-isomeric parent cpd; see also record for methylcholine; do not confuse with alpha-methylcholine | 2.02 | 1 | 0 | cholines | |
homocholine
homocholine: record includes halides; iodide used as internal standard for paired-ion HPLC assay for choline; RN given refers to parent cpd | 2.02 | 1 | 0 | | |
trimethylethylammonium
trimethylethylammonium: RN given refers to parent cpd. ethyltrimethylammonium : A quarternary ammonium cation having one ethyl and three methyl substituents around the central nitrogen. | 2.02 | 1 | 0 | quaternary ammonium ion | |
methylthioethanol
2-methylthioethanol : A primary alcohol that is the S-methyl derivative of mercaptoethanol. It is found as a volatile component in Cucumis melo Var. cantalupensis. | 2.02 | 1 | 0 | aliphatic sulfide;
primary alcohol | plant metabolite;
xenobiotic metabolite |
triethylcholine
triethylcholine: triethyl analog of choline with parasympatholytic properties; cholinergic false transmitter that mainly affects skeletal muscles; minor descriptor (75-86); on line & INDEX MEDICUS search CHOLINE/AA (75-86); RN given refers to parent cpd | 1.97 | 1 | 0 | | |
acetylcholine mustard
acetylcholine mustard: structure | 1.95 | 1 | 0 | | |
cyclocholine
cyclocholine: structure | 1.95 | 1 | 0 | | |
1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride
1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride: active against Ascaris lumbricoides suum; structure | 1.97 | 1 | 0 | | |
technetium tc 99m sestamibi
Technetium Tc 99m Sestamibi: A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack. | 2.82 | 2 | 0 | | |
sodium pertechnetate tc 99m
Sodium Pertechnetate Tc 99m: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints. | 2.41 | 1 | 0 | | |
piperidines
Piperidines: A family of hexahydropyridines. | 1.99 | 1 | 0 | | |