Compounds > 2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxylic acid
Page last updated: 2024-12-07

2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid : A monocarboxylic acid consisting of 2-(2-hydroxyphenyl)-4,5-dihydrothiazole having a carboxy group at the 4-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID98430
CHEMBL ID8770
CHEBI ID104585
SCHEMBL ID1534272
MeSH IDM0156782

Synonyms (26)

Synonym
49608-51-7
nsc-128295
nsc128295
CHEMDIV2_003477 ,
HMS1378O01
CHEMBL8770
CHEBI:104585 ,
2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
dihydroaeruginoic acid
2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid
2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxylic acid
AKOS004911527
2-(6-oxocyclohexa-2,4-dien-1-ylidene)-1,3-thiazolidine-4-carboxylic acid
htca
4-thiazolecarboxylic acid, 4,5-dihydro-2-(2-hydroxyphenyl)-
nsc 128295
SCHEMBL1534272
Q27182079
J-007772
SR-01000144148-1
sr-01000144148
EN300-209566
DTXSID201197921
4,5-dihydro-2-(2-hydroxyphenyl)-4-thiazolecarboxylic acid
2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylicacid
Z1509577581
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
monocarboxylic acidAn oxoacid containing a single carboxy group.
imidothioateA compound with the general formula R'-N=C(SR)R'' where R is organyl and R' and R'' can be organyl or H.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID99627Percent viability against L1210 leukemic cells at 0 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID154730Antiproliferative activity of compound expressed as concentration that inhibits 50% of growth of P388 leukemic cell suspension from 24 to 48 hr after compound addition1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID99631Percent viability against L1210 leukemic cells at 200 uM 1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID99629Percent viability against L1210 leukemic cells at 100 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID99623Percent viability against L1210 leukemic cells 48 hr after compound addition at 100 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID99489Antiproliferative activity of compound expressed as concentration that inhibits 50% of growth of L1210 leukemic cell suspension from 24 to 48 h after compound addition1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID99633Percent viability against L1210 leukemic cells at 50 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID154758Percent viability against P388 leukemic cells 48 hr after compound addition at 100 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID231065Partition ratio in 1-octanol / phosphate-buffered saline system1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
AID28835Solubility in phosphate-buffered saline (PBS) at pH 7.11989Journal of medicinal chemistry, May, Volume: 32, Issue:5
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (22.22)18.7374
1990's3 (33.33)18.2507
2000's1 (11.11)29.6817
2010's2 (22.22)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.54 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.84 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
choline
[no description available]		2.610cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		2.4420monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
hydroxyurea
[no description available]		2.3720one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent
thiazoles
[no description available]		3.39701,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
chorismic acid
Chorismic Acid: A cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS.. chorismic acid : The (3R,4R)-stereoisomer of 5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid.		2105-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acidEscherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
n-nitrosothiazolidine-4-carboxylic acid
N-nitrosothiazolidine-4-carboxylic acid: found in human urine		2.610organonitrogen compound;
organooxygen compound
fluorocholine
fluorocholine: a radiopharmaceutical agent		2.610
n,n-dimethyl-n-(18f)fluoromethyl-2-hydroxyethylammonium
[no description available]		2.610
pyochelin
pyochelin: phenolic iron-binding cpd from Pseudomonas aeruginosa; promotes the growth of bacterium when added to iron-deficient media. pyochelin : A member of the class of thiazolidines that is (4R)-3-methyl-1,3-thiazolidine-4-carboxylic acid which is substituted at position 2 by a (4R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazol-4-yl group. A siderophore that is produced by Pseudomonas aeruginosa (via condensation of salicylic acid and two molecules of cysteine) as a mixture of two easily interconvertible diastereoisomers, pyochelin I (major) and pyochelin II (minor). The enantiomeric compounds, enant-pyochelin, are produced by Pseudomonas fluorescens.		2.9340monocarboxylic acid;
phenols;
thiazolidines		metabolite;
siderophore
technetium tc 99m sestamibi
Technetium Tc 99m Sestamibi: A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.		2.610
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		2.6930monohydroxybenzoateplant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		02.3720
Primary Hyperparathyroidism
[description not available]		02.610
Hyperparathyroidism, Primary
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.		02.610
Infections, Pseudomonas
[description not available]		02.110
Pseudomonas Infections
Infections with bacteria of the genus PSEUDOMONAS.		02.110
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9710
Experimental Leukemia
[description not available]		01.9710