erythrocentaurin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

erythrocentaurin: isolated from Centaurium umbellatum Gilib, Enicostemma hyssopifolium & Swertia lawii; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Swertia	genus	A plant genus of the family GENTIANACEAE. It is a source of swertiapuniside and IRIDOID GLYCOSIDES.[MeSH]	Gentianaceae	A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]
Centaurium	genus	A plant genus of the family GENTIANACEAE. Triterpene lactones and other compounds have been isolated from species of this genus. The common name of century plant has also been used for the AGAVE genus.[MeSH]	Gentianaceae	A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]

Cross-References

ID Source	ID
PubMed CID	191120
CHEMBL ID	3397161
SCHEMBL ID	1649253
MeSH ID	M0050921

Synonyms (24)

Synonym
5-formyl-3,4-dihydroisocoumarin
erythrocentaurin
50276-98-7
1-oxo-3,4-dihydroisochromene-5-carbaldehyde
unii-295rs6d94v
295rs6d94v ,
erythrocentaurin [mi]
erythrocentaurine
1h-2-benzopyran-5-carboxaldehyde, 3,4-dihydro-1-oxo-
3,4-dihydro-1-oxo-1h-2-benzopyran-5-carboxaldehyde
isocoumarin, 5-formyl-3,4-dihydro-
SCHEMBL1649253
1-oxo-3,4-dihydro-1h-isochromene-5-carbaldehyde #
TUADBWMDDLWUME-UHFFFAOYSA-N
CHEMBL3397161
DTXSID30198282
5-formyl-2,3-dihydroisocoumarin
AKOS032949101
1-oxoisochroman-5-carbaldehyde
Q27254390
5-formyl-3,4-dihydroisocoumarin; 1-oxo-3,4-dihydroisochromene-5-carbaldehyde
1-oxo-3,4-dihydro-1h-2-benzopyran-5-carbaldehyde
CS-0024353
HY-N3861

Research Excerpts

Overview

Erythrocentaurin is a relatively simple natural product present among the members of Gentianaceae.

Excerpt	Reference	Relevance
"Erythrocentaurin is a relatively simple natural product present among the members of Gentianaceae. "	( Rapid preparative isolation of erythrocentaurin from Enicostemma littorale by medium-pressure liquid chromatography, its estimation by high-pressure thin-layer chromatography, and its α-amylase inhibitory activity. Ahamad, J; Amin, S; Hassan, N; Mir, SR; Mujeeb, M, 2015)	2.15

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID1192284	Inhibition of HBV HBsAg secretion in HepG2(2.2.15) cells after 72 hrs by ELISA method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors.
AID1192286	Inhibition of HBV HBeAg secretion in HepG2(2.2.15) cells after 72 hrs by ELISA method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors.
AID1192283	Cytotoxicity against human HepG2(2.2.15) cells after 72 hrs by MTT assay	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors.
AID1192288	Inhibition of HBV DNA replication in HepG2(2.2.15) cells exposed to fresh medium supplemented with compound every other day for additional 5 days by real-time PCR-fluorescent probing method	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors.
AID1192285	Selectivity index, ratio of CC50 for human HepG2(2.2.15) cells to IC50 for inhibition of HBV HBsAg secretion in HepG2(2.2.15) cells	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors.
AID1192287	Selectivity index, ratio of CC50 for human HepG2(2.2.15) cells to IC50 for inhibition of HBV HBeAg secretion in HepG2(2.2.15) cells	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors.
AID1192289	Selectivity index, ratio of CC50 for human HepG2(2.2.15) cells to IC50 for inhibition of HBV DNA replication in HepG2(2.2.15) cells	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (11.11)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (33.33)	29.6817
2010's	5 (55.56)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.21 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.21)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	1.95	1	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.44	2	D-glucopyranose	epitope; mouse metabolite
isocoumarins Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.. isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1.	3.64	9	isocoumarins
gentiopicroside gentiopicroside: a secoiridoid in Gentiana with rearrangement to two pyran rings	2.11	1	glycoside
swertiamarin swertiamarin: seco-iridoid glucoside from Swertia japonica;	7.77	3	glycoside
iridoids Iridoids: A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).	2.74	3
tenofovir tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.	2.11	1	nucleoside analogue; phosphonic acids	antiviral drug; drug metabolite; HIV-1 reverse transcriptase inhibitor
2,4-dinitrophenylhydrazine 2,4-dinitrophenylhydrazine: structure. 2,4-dinitrophenylhydrazine : A C-nitro compound that is phenylhydrazine substituted at the 2- and 4-positions by nitro groups.	2.52	2	C-nitro compound; phenylhydrazines	reagent
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.37	2	benzenes; hydroxycoumarin; methyl ketone

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