Page last updated: 2024-12-08

ai 77b

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Description

AI 77B: from Bacillus pumilus AI-77; has gastroprotective action; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID197216
CHEMBL ID28447
MeSH IDM0117899

Synonyms (15)

Synonym
ai-77-b
hexar-1-amic acid, 4-amino-4,5-dideoxy-n-(1-(3,4-dihydro-8-hydroxy-1-oxo- 1h-2-benzopyran-3-yl)-3-methylbutyl)-
ai 77b
brn 4338357
CHEMBL28447
(3s,4s,5s)-3-amino-4,5-dihydroxy-6-[[(1s)-1-[(3s)-8-hydroxy-1-oxo-3,4-dihydroisochromen-3-yl]-3-methylbutyl]amino]-6-oxohexanoic acid
77674-99-8
6-((1-(3,4-dihydro-8-hydroxy-1-oxo-1h-2-benzopyran-3-yl)-3-methylbutyl)amino)-4,5-dihydroxy-6-oxo-3-ammoniohexanoate
ai 77-b
amicoumacin b
(3s,4s,5s)-3-azaniumyl-4,5-dihydroxy-6-[[(1s)-1-[(3s)-8-hydroxy-1-oxo-3,4-dihydroisochromen-3-yl]-3-methylbutyl]amino]-6-oxohexanoate
(3s,4s,5s)-3-amino-4,5-dihydroxy-6-(((s)-1-((s)-8-hydroxy-1-oxoisochroman-3-yl)-3-methylbutyl)amino)-6-oxohexanoic acid
3-amino-2,3,6-trideoxy-6-[[(1s)-1-[(3s)-3,4-dihydro-8-hydroxy-1-oxo-1h-2-benzopyran-3-yl]-3-methylbutyl]amino]-6-oxo-d-ribo-hexonic acid
DTXSID101101719
AKOS040733970
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID15338Concentration 1 detected in blood of rat 1 hr after an oral dose of 200 mg/kg of the compound; ND is Not Detected.1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID188661Gastroprotective activity as % protection against stress ulcers in 5 rats after an intraperitoneal dose of 25 mg/kg1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID188674Gastroprotective activity on stress-induced ulcers in male Wistar rats at 6.25 mg/kg upon intraperitoneal administration1983Journal of medicinal chemistry, Oct, Volume: 26, Issue:10
1H-2-benzopyran-1-one derivatives, microbial products with pharmacological activity. Relationship between structure and activity in 6-[[1(S)-(3(S),4- dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]-amino]-4(S), 5(S)-dihydroxy-6-oxo-3(S)-ammon
AID188669Gastroprotective activity as % protection against stress ulcers in 5 rats after an oral dose of 25 mg/kg1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID188667Gastroprotective activity as % protection against stress ulcers in 5 rats after an oral dose of 12.5 mg/kg; NT is Not tested.1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID117092Lethal dose in mice upon intraperitoneal administration;Value ranges from(131.6-243.4)1983Journal of medicinal chemistry, Oct, Volume: 26, Issue:10
1H-2-benzopyran-1-one derivatives, microbial products with pharmacological activity. Relationship between structure and activity in 6-[[1(S)-(3(S),4- dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]-amino]-4(S), 5(S)-dihydroxy-6-oxo-3(S)-ammon
AID188658Gastroprotective activity as % protection against stress ulcers in 5 rats after an intraperitoneal dose of 12.5 mg/kg1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID15365Concentration detected in blood of rat 3 hr after an oral dose of 200 mg/kg; ND is Not Detected1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID1298881Anti-ulcer activity in Sprague-Dawley rat stomach assessed as protection against stress-induced gastric ulcer at 25 mg/kg, po pretreated for 30 mins followed by stress measured after 6 hrs relative to control2016European journal of medicinal chemistry, Jun-30, Volume: 116Isocoumarins, miraculous natural products blessed with diverse pharmacological activities.
AID188671Gastroprotective activity on stress-induced ulcers in male Wistar rats at 12.5 mg/kg upon intraperitoneal administration1983Journal of medicinal chemistry, Oct, Volume: 26, Issue:10
1H-2-benzopyran-1-one derivatives, microbial products with pharmacological activity. Relationship between structure and activity in 6-[[1(S)-(3(S),4- dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]-amino]-4(S), 5(S)-dihydroxy-6-oxo-3(S)-ammon
AID188672Gastroprotective activity on stress-induced ulcers in male Wistar rats at 25 mg/kg upon intraperitoneal administration1983Journal of medicinal chemistry, Oct, Volume: 26, Issue:10
1H-2-benzopyran-1-one derivatives, microbial products with pharmacological activity. Relationship between structure and activity in 6-[[1(S)-(3(S),4- dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]-amino]-4(S), 5(S)-dihydroxy-6-oxo-3(S)-ammon
AID188673Gastroprotective activity on stress-induced ulcers in male Wistar rats at 50 mg/kg upon intraperitoneal administration1983Journal of medicinal chemistry, Oct, Volume: 26, Issue:10
1H-2-benzopyran-1-one derivatives, microbial products with pharmacological activity. Relationship between structure and activity in 6-[[1(S)-(3(S),4- dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]-amino]-4(S), 5(S)-dihydroxy-6-oxo-3(S)-ammon
AID188662Gastroprotective activity as % protection against stress ulcers in 5 rats after an intraperitoneal dose of 50 mg/kg1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID20323% recovery from whole blood of 7 wistar rats after an oral dose of the compound1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID188670Gastroprotective activity as % protection against stress ulcers in 5 rats after an oral dose of 50 mg/kg1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
AID188663Gastroprotective activity as % protection against stress ulcers in 5 rats after an oral dose of 100 mg/kg1985Journal of medicinal chemistry, Jan, Volume: 28, Issue:1
1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.21 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.16 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]