benzylidenephthalide profile

benzylidenephthalide: contaminant of phenindione tablets considered as potentially immunogenic substance [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	700611
CHEMBL ID	1562463
SCHEMBL ID	5433929
MeSH ID	M0057694
PubMed CID	642371
CHEMBL ID	67365
CHEBI ID	113035
SCHEMBL ID	214423
MeSH ID	M0057694

Synonym
smr000217194
MLS000589956
3-[1-phenyl-meth-(e)-ylidene]-3h-isobenzofuran-1-one
einecs 209-388-8
1(3h)-isobenzofuranane, 3-(phenylmethylene)-
3-(phenylmethylene)-1(3h)-isobenzofuranone
nsc 2824
brn 0083797
benzylidenephthalide
ai3-17979
escalol 547
AKOS003614531
NCGC00246296-01
HMS2533B05
unii-n2s40871lm
ec 209-388-8
n2s40871lm ,
5-17-10-00577 (beilstein handbook reference)
SCHEMBL5433929
CHEMBL1562463
c9e8s3agyq ,
trans-3-benzylidenephthalide
4767-55-9
1(3h)-isobenzofuranone, 3-(phenylmethylene)-, (3e)-
trans-3-(phenylmethylene)phthalide
unii-c9e8s3agyq
benzalphthalide, (e)-
J-519667
(e)-3-benzylidenephthalide
1,4-diaminopiperazinehydrate
(e)-benzalphthalide
Q27275358
3-(phenylmethylidene)-1,3-dihydro-2-benzofuran-1-one
EN300-13345571
(e)-3-benzylideneisobenzofuran-1(3h)-one
HMS2619E19
phthalide, 3-benzylidene-
1(3h)-isobenzofuranone, 3-(phenylmethylene)-
nsc2824
3-benzylidenephthalide
575-61-1
3-benzalphthalide
nsc-2824
benzalphthalide
MLS000584766
smr000203729
1(3h)-isobenzofuranone, 3-(phenyl)methylene]-, (3z)-
(3z)-3-benzylideneisobenzofuran-1-one
inchi=1/c15h10o2/c16-15-13-9-5-4-8-12(13)14(17-15)10-11-6-2-1-3-7-11/h1-10h/b14-10
1(3h)-isobenzofuranone, 3-(phenylmethylene)-, (3z)-
(3z)-3-benzylidene-2-benzofuran-1(3h)-one
CHEBI:113035
AC-11676
B1214 ,
CHEMBL67365 ,
(3z)-3-benzylidene-2-benzofuran-1-one
3-benzylidene-2-benzofuran-1(3h)-one
HMS1610I16
AKOS000567737
STK862417
3-benzylideneisobenzofuran-1(3h)-one
A831503
NCGC00245849-01
4767-56-0
SCHEMBL214423
AE-641/05032029
bdbm50441021
BBL027545
benzalphthalid
YRTPZXMEBGTPLM-UVTDQMKNSA-N
(3z)-3-benzylidene-2-benzofuran-1(3h)-one #
benzalphthalide, (z)-
r93gn14k61 ,
unii-r93gn14k61
(z)-3-benzylidenephthalide
AC-31127
mfcd00005929
sr-01000438153
SR-01000438153-1
(3z)-3-(phenylmethylidene)-1,3-dihydro-2-benzofuran-1-one
VS-08562
3-benzylidene-3h-isobenzofuran-1-one
(z)-3-benzylideneisobenzofuran-1(3h)-one
AT15806
Q27287989
(z)-benzalphthalide
3-[1-phenyl-meth-(z)-ylidene]-3h-isobenzofuran-1-one
PD119248
CS-0067707
HY-118659

Protein Targets (21)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	22.3872	0.0040	23.8416	100.0000	AID485290
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	56.2341	0.6310	35.7641	100.0000	AID504339
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	28.1838	0.1778	14.3909	39.8107	AID2147
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	25.1189	5.6234	17.2929	31.6228	AID485281
Luciferase	Photinus pyralis (common eastern firefly)	Potency	11.9955	0.0072	15.7588	89.3584	AID588342
T cell receptor, partial	Homo sapiens (human)	Potency	5.6234	0.9960	3.6401	6.2841	AID504894
ClpP	Bacillus subtilis	Potency	25.1189	1.9953	22.6730	39.8107	AID651965
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	39.8107	0.7079	12.1943	39.8107	AID720542
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	25.1189	0.0112	12.4002	100.0000	AID1030
glucocerebrosidase	Homo sapiens (human)	Potency	50.1187	0.0126	8.1569	44.6684	AID2101
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	56.2341	0.7079	36.9043	89.1251	AID504333
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	28.1838	0.0018	15.6638	39.8107	AID894
chromobox protein homolog 1	Homo sapiens (human)	Potency	89.1251	0.0060	26.1688	89.1251	AID540317
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	0.1995	0.1000	28.9256	213.3130	AID588591
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	31.6228	0.0752	15.2253	39.8107	AID485360
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	63.0957	0.6310	35.7641	100.0000	AID504339
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	31.6228	0.1778	14.3909	39.8107	AID2147
Luciferase	Photinus pyralis (common eastern firefly)	Potency	11.9955	0.0072	15.7588	89.3584	AID588342
chaperonin-containing TCP-1 beta subunit homolog	Homo sapiens (human)	Potency	17.7828	3.9811	27.7649	39.8107	AID504842
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	39.8107	0.7079	12.1943	39.8107	AID720542
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	37.6505	0.0112	12.4002	100.0000	AID1030
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	56.2341	0.7079	36.9043	89.1251	AID504333
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	50.1187	0.0355	20.9770	89.1251	AID504332
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	35.4813	0.0018	15.6638	39.8107	AID894
chromobox protein homolog 1	Homo sapiens (human)	Potency	50.1187	0.0060	26.1688	89.1251	AID540317
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	33.5875	0.1683	16.4040	67.0158	AID720504
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	22.3872	0.0752	15.2253	39.8107	AID485360
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	39.8107	0.0041	9.9625	28.1838	AID2675
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Transient receptor potential cation channel subfamily A member 1	Rattus norvegicus (Norway rat)	IC50 (µMol)	2.9000	0.4500	3.4243	7.5000	AID772955
Transient receptor potential cation channel subfamily M member 8	Rattus norvegicus (Norway rat)	IC50 (µMol)	9.2500	0.0580	2.6504	8.3000	AID772951; AID772952
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Transient receptor potential cation channel subfamily A member 1	Rattus norvegicus (Norway rat)	EC50 (µMol)	3.0000	0.0600	2.2223	8.4000	AID772956
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (42)

Assay ID	Title	Year	Journal	Article
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID772957	Agonist activity at rat recombinant TRPA1 overexpressed in HEK293 cells assessed as induction of intracellular calcium influx by Fluo-4-AM dye-based spectrofluorimetric analysis relative to allyl isothiocyanate	2013	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20	3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
AID772956	Agonist activity at rat recombinant TRPA1 overexpressed in HEK293 cells assessed as induction of intracellular calcium influx by Fluo-4-AM dye-based spectrofluorimetric analysis	2013	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20	3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
AID772955	Antagonist activity at rat recombinant TRPA1 overexpressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influx preincubated for 5 mins followed by allyl isothiocyanate challenge by Fluo-4-AM dye-based spectr	2013	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20	3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
AID772952	Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium influx preincubated for 5 mins followed by icilin challenge by Fluo-4-AM dye-based spectrofluorimetric analysis	2013	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20	3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
AID99864	In vitro inhibitory activity against Leishmania amazonensis (PH8)	2001	Bioorganic & medicinal chemistry letters, Aug-20, Volume: 11, Issue:16	Leishmanicidal activity of some stilbenoids and related heterocyclic compounds.
AID213788	Inhibitory concentration against epimastigotes (Tulahuen strain) of Trypanosoma cruzi; Inactive	2001	Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20	Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds.
AID100420	In vitro inhibitory activity against Leishmania donovani (PP75)	2001	Bioorganic & medicinal chemistry letters, Aug-20, Volume: 11, Issue:16	Leishmanicidal activity of some stilbenoids and related heterocyclic compounds.
AID772954	Agonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as induction of intracellular calcium influx by Fluo-4-AM dye-based spectrofluorimetric analysis relative to ionomycin	2013	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20	3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
AID772953	Agonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as induction of intracellular calcium influx by Fluo-4-AM dye-based spectrofluorimetric analysis	2013	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20	3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
AID213787	Inhibitory concentration against Epimastigotes (Tulahuen strain) of Trypanosoma cruzi	2001	Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20	Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds.
AID99990	In vitro inhibitory activity against Leishmania braziliensis (M2903)	2001	Bioorganic & medicinal chemistry letters, Aug-20, Volume: 11, Issue:16	Leishmanicidal activity of some stilbenoids and related heterocyclic compounds.
AID772951	Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of menthol-induced intracellular calcium influx preincubated for 5 mins followed by menthol challenge by Fluo-4-AM dye-based spectrofluorimetric analysis	2013	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20	3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
AID229349	Ratio of inhibitory concentration to that of reference drug was determined	2001	Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20	Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds.
AID213793	Inhibitory concentration against trypomastigotes (Y strain) of Trypanosoma cruzi; Inactive	2001	Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20	Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (8.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (25.00)	29.6817
2010's	7 (58.33)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phenindione Phenindione: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)	6.95	1	aromatic ketone; beta-diketone	anticoagulant
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.08	1	metal allergen; nickel group element atom; platinum group metal atom
isocoumarins Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.. isocoumarin : The simplest member of the class of isocoumarins that is 1H-isochromene which is substituted by an oxo group at position 1.	7.08	1	isocoumarins
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	2	1	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
gentian violet Gentian Violet: A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.. crystal violet : An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain.	2	1	organic chloride salt	anthelminthic drug; antibacterial agent; antifungal agent; antiseptic drug; histological dye
benzonidazole benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.	2	1	C-nitro compound; imidazoles; monocarboxylic acid amide	antiprotozoal drug
butylidenephthalide [no description available]	2.08	1	2-benzofurans; gamma-lactone	EC 3.2.1.20 (alpha-glucosidase) inhibitor; hypoglycemic agent; metabolite
ligustilide ligustilide: found in Umbelliferae plants; RN given refers to cpd without isomeric designation; structure in first source	2.08	1	butenolide	metabolite

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.46	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.46	2
Allergy, Drug [description not available]	1.95	1
Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally.	1.95	1
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1

benzylidenephthalide

Description

Cross-References

Synonyms (90)

Protein Targets (21)

Potency Measurements

Inhibition Measurements

Activation Measurements

Bioassays (42)

Research

Studies (12)

Market Indicators

Research Demand Index: 11.91

Study Types

benzylidenephthalide

Description

Cross-References

Synonyms (90)

Protein Targets (21)

Potency Measurements

Inhibition Measurements

Activation Measurements

Bioassays (42)

Research

Studies (12)

Market Indicators

Research Demand Index: 11.91

Study Types

Related Drugs (8)

Related Conditions (6)